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BioGRID | Network Layout for PPH21 for Saccharomyces cerevisiae
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PPH21

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: PPH1, YDL134C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with PPH21

PPH21 was identified with 60 protein interactions and 87 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 TPD3
  • FUN32
  • YAL016W
    		•  The BioGRID Database Seperator Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Wei H (2001) [3]
    bait/hit Jiang Y (1999) [12]
    bait Wang H (2003) [6]
    hit Hombauer H (2007) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAP42
  • YMR028W
    		•  The BioGRID Database Seperator Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    Affinity Capture-Western
    hit Jiang Y (1999) [12]
    bait Wang H (2003) [6]
    bait Wang H (2003) [3]
    hit Hombauer H (2007) [6]
    Reconstituted Complex
    bait Van Hoof C (2005) [10]
    Co-purification
    bait Yan G (2006) [7]
    Two-hybrid
    bait Yu H (2008) [1778]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC55
  • YGL190C
    		•  The BioGRID Database Seperator Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at the bud neck and at the bud tip
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Wei H (2001) [3]
    hit Jiang Y (1999) [12]
    Synthetic Rescue
    bait Yang H (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPH22
  • PPH2
  • YDL188C
    		•  The BioGRID Database Seperator Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Collins SR (2007) [9064]
    Synthetic Growth Defect
    bait Sakumoto N (2002) [3]
    Synthetic Lethality
    hit Sneddon AA (1990) [1]
    hit Ronne H (1991) [1]
    bait Clotet J (1995) [1]
    hit Van Hoof C (2001) [2]
    Phenotypic Enhancement
    hit Wang Y (2006) [20]
    bait Pal G (2008) [17]
    hit Tate JJ (2009) [1]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTS1
  • SCS1
  • YOR014W
    		•  The BioGRID Database Seperator B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    bait Gavin AC (2006) [7592]
    Affinity Capture-Western
    hit Wei H (2001) [3]
    bait Shu Y (1997) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIP41
  • YPR040W
    		•  The BioGRID Database Seperator Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [1585]
    bait Gingras AC (2005) [75]
    Affinity Capture-Western
    bait Kuepfer L (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BZZ1
  • LSB7
  • YHR114W
    		•  The BioGRID Database Seperator SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [1585]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRD2
  • YPA2
  • YPL152W
    		•  The BioGRID Database Seperator Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Van Hoof C (2005) [10]
    Affinity Capture-Western
    bait Zheng Y (2005) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS2
  • CES4
  • YML109W
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTS3
  • YGR161C
    		•  The BioGRID Database Seperator Putative component of the protein phosphatase type 2A complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS1
  • CKM1
  • CES1
  • OSS1
  • YMR273C
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR2
  • DRR2
  • YKL203C
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    Co-purification
    bait Yan G (2006) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUN1
  • YDL101C
    		•  The BioGRID Database Seperator Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRD1
  • YPA1
  • YIL153W
    		•  The BioGRID Database Seperator Activator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zheng Y (2005) [14]
    Synthetic Growth Defect
    hit Van Hoof C (2001) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN8
  • SDS15
  • KSL2
  • YEL061C
    		•  The BioGRID Database Seperator Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2004) [323]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB1
  • YGR188C
    		•  The BioGRID Database Seperator Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC5
  • PKX2
  • MSD2
  • YMR001C
    		•  The BioGRID Database Seperator Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
    Gene Ontology: [View List]
    Dosage Lethality
    bait Wang Y (2006) [20]
    Dosage Rescue
    hit Nakashima A (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HFM1
  • MER3
  • YGL251C
    		•  The BioGRID Database Seperator Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPE1
  • YHR075C
    		•  The BioGRID Database Seperator Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPC40
  • RPC5
  • YPR110C
    		•  The BioGRID Database Seperator RNA polymerase subunit, common to RNA polymerase I and III
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGO1
  • YOR29-24
  • YOR073W
    		•  The BioGRID Database Seperator Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Riedel CG (2006) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPS1
  • YDR523C
    		•  The BioGRID Database Seperator Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHR1
  • YOR386W
    		•  The BioGRID Database Seperator DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSP1
  • YPL004C
    		•  The BioGRID Database Seperator Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEM15
  • YOR176W
    		•  The BioGRID Database Seperator Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRN1
  • YLR429W
    		•  The BioGRID Database Seperator Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OM45
  • YIL136W
    		•  The BioGRID Database Seperator Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOC1
  • YJR075W
    		•  The BioGRID Database Seperator Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VRP1
  • YLR337W
  • MDP2
  • END5
  • YLR337C
    		•  The BioGRID Database Seperator Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRP1
  • RRP47
  • YHR081W
    		•  The BioGRID Database Seperator Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR125W
  • YGR125W
    		•  The BioGRID Database Seperator Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO41
  • YFL036W
    		•  The BioGRID Database Seperator Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS167
  • YDR388W
    		•  The BioGRID Database Seperator Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR248C
  • YDR248C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BLM10
  • YFL006W
  • YFL007W
    		•  The BioGRID Database Seperator Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEG1
  • PUS3
  • YFL001W
    		•  The BioGRID Database Seperator Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAL12
  • YGR292W
    		•  The BioGRID Database Seperator Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ROM2
  • YLR371W
    		•  The BioGRID Database Seperator GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHR009C
  • YHR009C
    		•  The BioGRID Database Seperator Putative protein of unknown function; not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR071W
  • YPR071W
    		•  The BioGRID Database Seperator Putative membrane protein; YPR071W is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUO1
  • YGL061C
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AFR1
  • YDR085C
    		•  The BioGRID Database Seperator Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUP5
  • VMA3
  • CLS7
  • GEF2
  • YEL027W
    		•  The BioGRID Database Seperator Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI3
  • TYE2
  • YJL176C
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
    Gene Ontology: [View List]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC3
  • YLR314C
    		•  The BioGRID Database Seperator Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
    Gene Ontology: [View List]
    Positive Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES3
  • YLR052W
    		•  The BioGRID Database Seperator Subunit of the INO80 chromatin remodeling complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Hannum G (2009) [496]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP4
  • RNA4
  • YPR178W
    		•  The BioGRID Database Seperator Splicing factor, component of the U4/U6-U5 snRNP complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET16
  • YPR167C
    		•  The BioGRID Database Seperator 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR3
  • OSR11
  • YPR141C
    		•  The BioGRID Database Seperator Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIW14
  • OCA3
  • YNL032W
    		•  The BioGRID Database Seperator Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIK1
  • YMR198W
    		•  The BioGRID Database Seperator Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASE1
  • YOR29-09
  • YOR058C
    		•  The BioGRID Database Seperator Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YME1
  • YTA11
  • OSD1
  • YPR024W
    		•  The BioGRID Database Seperator Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AXL1
  • FUS5
  • STE22
  • YPR122W
    		•  The BioGRID Database Seperator Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR096C
  • YPR096C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAR3
  • YMR052W
    		•  The BioGRID Database Seperator Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Synthetic Haploinsufficiency
    bait Haarer B (2007) [201]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • YOR368W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRI1
  • YIR008C
    		•  The BioGRID Database Seperator Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPH3
  • YDR075W
    		•  The BioGRID Database Seperator Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Pal G (2008) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPS1
  • FDP1
  • GGS1
  • CIF1
  • YBR126C
    		•  The BioGRID Database Seperator Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
    Gene Ontology: [View List]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT6
  • SSN20
  • CRE2
  • YGR116W
    		•  The BioGRID Database Seperator Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation
    Gene Ontology: [View List]
    Positive Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAT2
  • YEL056W
    		•  The BioGRID Database Seperator Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AMN1
  • CST13
  • ICS4
  • YBR158W
    		•  The BioGRID Database Seperator Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Wang Y (2006) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHO2
  • YNL090W
    		•  The BioGRID Database Seperator Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
    Gene Ontology: [View List]
    Dosage Rescue
    hit Wang H (2003) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
    Gene Ontology: [View List]
    Dosage Rescue
    hit Lin FC (1995) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MIH1
  • YMR036C
    		•  The BioGRID Database Seperator Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Lin FC (1995) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • SRM5
  • HSL5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Lin FC (1995) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOB1
  • YIL106W
    		•  The BioGRID Database Seperator Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
    Gene Ontology: [View List]
    Dosage Lethality
    bait Wang Y (2006) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAM1
  • YDR251W
    		•  The BioGRID Database Seperator Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
    Gene Ontology: [View List]
    Dosage Rescue
    hit Hu GZ (1994) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPA2
  • IPP2
  • YMR267W
    		•  The BioGRID Database Seperator Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
    Gene Ontology: [View List]
    Positive Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI5
  • YOR083W
    		•  The BioGRID Database Seperator Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
    Gene Ontology: [View List]
    Positive Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS8A
  • YBL072C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN82
  • YCR091W
    		•  The BioGRID Database Seperator Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL19B
  • YBL027W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AIM4
  • YBR194W
    		•  The BioGRID Database Seperator Protein proposed to be associated with the nuclear pore complex; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and a severe growth defect in minimal glycerol media
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHK1
  • YBR274W
    		•  The BioGRID Database Seperator Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PYC2
  • YBR218C
    		•  The BioGRID Database Seperator Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AME1
  • ARP100
  • YBR211C
    		•  The BioGRID Database Seperator Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHP1
  • UBX1
  • YBL058W
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OCA5
  • YHL029C
    		•  The BioGRID Database Seperator Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
    Gene Ontology: [View List]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBP2
  • YDR162C
    		•  The BioGRID Database Seperator Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM1
  • SPB8
  • YJL124C
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
    Gene Ontology: [View List]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADO1
  • YJR105W
    		•  The BioGRID Database Seperator Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
    Gene Ontology: [View List]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD9
  • YDR217C
    		•  The BioGRID Database Seperator DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Strome ED (2008) [161]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DYN1
  • PAC6
  • DHC1
  • YKR054C
    		•  The BioGRID Database Seperator Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Chan LY (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PER1
  • COS16
  • YCR044C
    		•  The BioGRID Database Seperator Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.