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BioGRID | Network Layout for RPO21 for Saccharomyces cerevisiae
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RPO21

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SUA8, RPB220, RPB1, YDL140C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 15 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RPO21

RPO21 was identified with 370 protein interactions and 148 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RPB3
  • YIL021W
    		•  The BioGRID Database Seperator RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004) [890]
    bait/hit Krogan NJ (2002) [90]
    hit Nair D (2005) [2]
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    Affinity Capture-Western
    hit Leblanc BP (2000) [8]
    hit Chen HT (2003) [3]
    bait Tardiff DF (2007) [46]
    Co-crystal Structure
    hit Kettenberger H (2004) [11]
    Co-purification
    hit Otero G (1999) [5]
    bait Sung P (1996) [11]
    hit Suh MH (2005) [9]
    Co-fractionation
    bait Rosenheck S (1998) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESS1
  • PIN1
  • PTF1
  • YJR017C
    		•  The BioGRID Database Seperator Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    hit Morris DP (1999) [2]
    hit Phatnani HP (2004) [10]
    bait Krogan NJ (2006) [7079]
    Affinity Capture-Western
    bait Morris DP (2000) [3]
    Far Western
    hit Wu X (2000) [10]
    Reconstituted Complex
    bait Myers JK (2001) [1]
    bait Morris DP (1999) [2]
    Two-hybrid
    bait/hit Wu X (2001) [9]
    bait/hit Wu X (2000) [10]
    Biochemical Activity
    bait Kops O (2002) [1]
    Synthetic Lethality
    bait Wu X (2000) [10]
    bait Wilcox CB (2004) [7]
    Dosage Rescue
    bait Wu X (2001) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSP5
  • UBY1
  • SMM1
  • MUT2
  • YER125W
    		•  The BioGRID Database Seperator Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Affinity Capture-Western
    bait Morris DP (2000) [3]
    bait Chang A (2000) [3]
    bait Somesh BP (2007) [2]
    Far Western
    bait Morris DP (2000) [3]
    hit Chang A (2000) [3]
    Reconstituted Complex
    bait Wang G (1999) [1]
    Two-hybrid
    bait/hit Wu X (2001) [9]
    hit Chang A (2000) [3]
    Biochemical Activity
    bait Huibregtse JM (1997) [1]
    bait Somesh BP (2005) [4]
    bait Saeki Y (2009) [13]
    Dosage Rescue
    bait Wu X (2001) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO26
  • RPB6
  • YPR187W
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004) [890]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait/hit Nouraini S (1996) [7]
    hit Leblanc BP (2000) [8]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    hit Kettenberger H (2004) [11]
    Co-purification
    hit Suh MH (2005) [9]
    Dosage Rescue
    hit Archambault J (1990) [2]
    hit Archambault J (1992) [1]
    hit Minakhin L (2001) [1]
    Synthetic Lethality
    bait/hit Nouraini S (1996) [7]
    bait/hit Nouraini S (1996) [2]
    bait Archambault J (1990) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB7
  • YDR404C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004) [890]
    bait Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    Affinity Capture-Western
    bait/hit Sheffer A (1999) [5]
    hit Leblanc BP (2000) [8]
    hit Daulny A (2008) [15]
    Co-crystal Structure
    hit Kettenberger H (2004) [11]
    hit Jensen GJ (1998) [5]
    Co-purification
    hit Suh MH (2005) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB5
  • YBR154C
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004) [890]
    bait Krogan NJ (2006) [7079]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Leblanc BP (2000) [8]
    Co-crystal Structure
    bait Cramer P (2000) [12]
    hit Kettenberger H (2004) [11]
    Two-hybrid
    bait Flores A (1999) [20]
    bait Zaros C (2007) [7]
    Co-purification
    hit Otero G (1999) [5]
    hit Suh MH (2005) [9]
    Synthetic Lethality
    bait Miyao T (1998) [1]
    Synthetic Growth Defect
    bait Zaros C (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB2
  • SIT2
  • SOH2
  • RPO22
  • YOR151C
    		•  The BioGRID Database Seperator RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004) [890]
    hit Nair D (2005) [2]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Leblanc BP (2000) [8]
    Co-crystal Structure
    bait Cramer P (2000) [12]
    hit Kettenberger H (2004) [11]
    Co-purification
    hit Otero G (1999) [5]
    hit Suh MH (2005) [9]
    Phenotypic Enhancement
    bait Lennon JC (1998) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB9
  • SHI1
  • SSU73
  • YGL070C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Tan Q (2003) [13]
    Co-crystal Structure
    bait Cramer P (2000) [12]
    hit Kettenberger H (2004) [11]
    Two-hybrid
    bait Flores A (1999) [20]
    Co-purification
    bait Donaldson IM (2000) [9]
    Synthetic Growth Defect
    hit Gaillard H (2009) [26]
    Synthetic Lethality
    hit Walmacq C (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT5
  • YML010W
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004) [890]
    bait Lindstrom DL (2003) [113]
    bait/hit Krogan NJ (2002) [90]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Lindstrom DL (2001) [14]
    hit Liu Y (2009) [9]
    bait Ding B (2009) [7]
    Synthetic Growth Defect
    hit Lindstrom DL (2001) [14]
    hit Hartzog GA (1998) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB4
  • CTF15
  • YJL140W
    		•  The BioGRID Database Seperator RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004) [890]
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Sheffer A (1999) [5]
    hit Leblanc BP (2000) [8]
    bait Goler-Baron V (2008) [6]
    Co-crystal Structure
    hit Kettenberger H (2004) [11]
    hit Jensen GJ (1998) [5]
    Co-purification
    hit Otero G (1999) [5]
    hit Suh MH (2005) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET2
  • EZL1
  • YJL168C
    		•  The BioGRID Database Seperator Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Krogan NJ (2003) [54]
    bait Xiao T (2003) [1]
    bait Schaft D (2003) [11]
    Affinity Capture-MS
    bait Li B (2003) [5]
    bait Li J (2002) [2]
    hit Phatnani HP (2004) [10]
    bait Krogan NJ (2006) [7079]
    Protein-peptide
    bait Li B (2003) [5]
    Reconstituted Complex
    hit Phatnani HP (2004) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN28
  • YDL108W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
    Gene Ontology: [View List]
    Biochemical Activity
    bait Keogh MC (2003) [7]
    bait Rodriguez CR (2000) [6]
    bait Hengartner CJ (1998) [5]
    bait Cismowski MJ (1995) [1]
    bait Feaver WJ (1994) [4]
    hit Max T (2007) [3]
    hit Akhtar MS (2009) [6]
    Far Western
    bait Feaver WJ (1994) [4]
    Affinity Capture-Western
    hit Liu Y (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB5
  • MED18
  • YGR104C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Mueller CL (2002) [20]
    bait Zaman Z (2001) [10]
    bait Liu Y (2001) [56]
    bait Linder T (2006) [22]
    Reconstituted Complex
    hit Thompson CM (1993) [12]
    Affinity Capture-MS
    bait Liu Y (2001) [56]
    Co-purification
    hit Gaudreau L (1998) [3]
    bait Liao SM (1995) [14]
    Synthetic Rescue
    hit Thompson CM (1993) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASR1
  • YPR093C
    		•  The BioGRID Database Seperator Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Daulny A (2008) [15]
    Far Western
    bait Daulny A (2008) [15]
    Biochemical Activity
    bait Daulny A (2008) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFG2
  • YGR005C
    		•  The BioGRID Database Seperator TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004) [890]
    bait/hit Krogan NJ (2002) [90]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Chung WH (2003) [9]
    bait Shi X (1997) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB8
  • YOR224C
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
    Gene Ontology: [View List]
    Two-hybrid
    bait Briand JF (2001) [13]
    Affinity Capture-Western
    hit Leblanc BP (2000) [8]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    hit Kettenberger H (2004) [11]
    Co-purification
    hit Suh MH (2005) [9]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFG1
  • RAP74
  • SSU71
  • YGR186W
    		•  The BioGRID Database Seperator TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004) [890]
    bait/hit Krogan NJ (2002) [90]
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Co-purification
    bait Wade PA (1996) [24]
    Synthetic Rescue
    bait/hit Majovski RC (2005) [2]
    bait/hit Freire-Picos MA (2005) [4]
    Phenotypic Suppression
    hit Freire-Picos MA (2005) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEG1
  • YGL130W
    		•  The BioGRID Database Seperator Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Rodriguez CR (2000) [6]
    hit Cho EJ (1998) [4]
    hit McCracken S (1997) [2]
    Reconstituted Complex
    bait Schroeder SC (2000) [2]
    Protein-peptide
    bait Takagi T (2002) [1]
    Synthetic Lethality
    bait Cho EJ (1997) [2]
    bait Kim HJ (2004) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB11
  • YOL005C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Leblanc BP (2000) [8]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    hit Kettenberger H (2004) [11]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCF11
  • YDR228C
    		•  The BioGRID Database Seperator mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Sadowski M (2003) [6]
    Two-hybrid
    hit Sadowski M (2003) [6]
    hit Kyburz A (2003) [17]
    bait Dichtl B (2002) [4]
    Protein-peptide
    bait Dichtl B (2002) [4]
    Synthetic Growth Defect
    hit Licatalosi DD (2002) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGV1
  • BUR1
  • YPR161C
    		•  The BioGRID Database Seperator Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Murray S (2001) [12]
    Reconstituted Complex
    bait Murray S (2001) [12]
    Biochemical Activity
    bait Keogh MC (2003) [7]
    bait Murray S (2001) [12]
    hit Liu Y (2009) [9]
    Synthetic Growth Defect
    bait Murray S (2001) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NRD1
  • YNL251C
    		•  The BioGRID Database Seperator RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Sadowski M (2003) [6]
    Two-hybrid
    hit Sadowski M (2003) [6]
    Affinity Capture-MS
    bait Vasiljeva L (2006) [23]
    Affinity Capture-Western
    bait Vasiljeva L (2008) [4]
    Protein-peptide
    bait Vasiljeva L (2008) [4]
    Synthetic Lethality
    bait Conrad NK (2000) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB4
  • MED17
  • YER022W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Thompson CM (1993) [12]
    Co-purification
    hit Gaudreau L (1998) [3]
    hit Gustafsson CM (1997) [6]
    bait Takagi Y (2006) [28]
    Affinity Capture-Western
    hit Liu Y (2009) [9]
    Synthetic Rescue
    hit Thompson CM (1993) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DST1
  • PPR2
  • YGL043W
    		•  The BioGRID Database Seperator General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2002) [90]
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Dosage Rescue
    hit Archambault J (1992) [1]
    Synthetic Lethality
    bait Hartzog GA (1998) [8]
    hit Guglielmi B (2007) [3]
    Phenotypic Enhancement
    bait Lennon JC (1998) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGR1
  • MED14
  • YLR071C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Han SJ (1999) [22]
    Affinity Capture-Western
    bait Kang JS (2001) [53]
    bait Lee YC (1999) [19]
    bait Liu Y (2001) [56]
    Co-purification
    bait Lee YC (1997) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004) [890]
    bait/hit Krogan NJ (2002) [90]
    bait Sanders SL (2002) [483]
    bait Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTR1
  • YER139C
    		•  The BioGRID Database Seperator Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    Affinity Capture-Western
    bait Gibney PA (2008) [17]
    Biochemical Activity
    bait Mosley AL (2009) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUA7
  • SOH4
  • YPR086W
    		•  The BioGRID Database Seperator Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Cho EJ (1999) [1]
    hit Pardee TS (1998) [1]
    Co-crystal Structure
    bait Bushnell DA (2004) [2]
    Affinity Capture-Western
    hit Chen HT (2003) [3]
    Synthetic Lethality
    bait Berroteran RW (1994) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB10
  • YOR210W
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
    Gene Ontology: [View List]
    Two-hybrid
    hit Flores A (1999) [20]
    Co-crystal Structure
    hit Kettenberger H (2004) [11]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOG1
  • SSK3
  • YLR113W
    		•  The BioGRID Database Seperator Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Alepuz PM (2003) [6]
    bait Proft M (2006) [6]
    Reconstituted Complex
    bait Alepuz PM (2003) [6]
    bait Proft M (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT103
  • YDR289C
    		•  The BioGRID Database Seperator Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Protein-peptide
    bait Kim M (2004) [19]
    bait Vasiljeva L (2008) [4]
    Affinity Capture-MS
    bait Kim M (2004) [19]
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CFT1
  • YHH1
  • YDR301W
    		•  The BioGRID Database Seperator RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Dichtl B (2002) [4]
    Two-hybrid
    hit Dichtl B (2002) [4]
    bait Kyburz A (2003) [17]
    Affinity Capture-Western
    bait Nordick K (2008) [38]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNA14
  • YMR061W
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Sadowski M (2003) [6]
    Two-hybrid
    hit Sadowski M (2003) [6]
    Affinity Capture-Western
    hit Barilla D (2001) [5]
    bait Runner VM (2008) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kvint K (2008) [16]
    Co-purification
    bait Kvint K (2008) [16]
    Biochemical Activity
    bait Kvint K (2008) [16]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB6
  • MED22
  • YBR253W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    Affinity Capture-Western
    bait Liu Y (2001) [56]
    Reconstituted Complex
    hit Thompson CM (1993) [12]
    Synthetic Rescue
    hit Thompson CM (1993) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN3
  • NUT7
  • GIG2
  • CDK8
  • YPL042C
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
    Gene Ontology: [View List]
    Biochemical Activity
    bait Keogh MC (2003) [7]
    bait Rodriguez CR (2000) [6]
    bait Hengartner CJ (1998) [5]
    Synthetic Rescue
    hit Hengartner CJ (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT4
  • YGR063C
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2002) [90]
    bait Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Synthetic Growth Defect
    hit Lindstrom DL (2001) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Mueller CL (2002) [20]
    bait Shi X (1997) [13]
    Reconstituted Complex
    bait Shi X (1997) [13]
    Synthetic Growth Defect
    hit Chu Y (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FCP1
  • YMR277W
    		•  The BioGRID Database Seperator Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
    Gene Ontology: [View List]
    Protein-peptide
    bait Kong SE (2005) [113]
    Reconstituted Complex
    bait Suh MH (2005) [9]
    Biochemical Activity
    bait Suh MH (2005) [9]
    Synthetic Lethality
    bait Kobor MS (1999) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEN1
  • CIK3
  • NRD2
  • YLR430W
    		•  The BioGRID Database Seperator Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis
    Gene Ontology: [View List]
    Two-hybrid
    bait Ursic D (2004) [15]
    Affinity Capture-Western
    bait Ursic D (2004) [15]
    Synthetic Growth Defect
    bait Ursic D (2004) [15]
    Phenotypic Enhancement
    hit Vasiljeva L (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP2
  • TOT2
  • YGR200C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Frohloff F (2003) [10]
    bait Fellows J (2000) [14]
    Co-purification
    bait Fellows J (2000) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED6
  • YHR058C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gustafsson CM (1997) [6]
    Biochemical Activity
    bait Keogh MC (2003) [7]
    Co-purification
    bait Lee YC (1997) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT15
  • TBP1
  • BTF1
  • YER148W
    		•  The BioGRID Database Seperator TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Thompson CM (1993) [12]
    Co-localization
    hit Kaplan CD (2003) [1]
    Affinity Capture-Western
    hit Liu Y (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL3
  • MTR13
  • MTS1
  • NAB1
  • YDR432W
    		•  The BioGRID Database Seperator RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lei EP (2001) [1]
    bait Tardiff DF (2007) [46]
    Affinity Capture-MS
    bait Tardiff DF (2007) [46]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IWR1
  • YDL115C
    		•  The BioGRID Database Seperator Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL11
  • SPT13
  • ABE1
  • MED15
  • YOL051W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Sakurai H (1996) [5]
    Co-purification
    hit Gaudreau L (1998) [3]
    Affinity Capture-Western
    hit Esnault C (2008) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KTI12
  • TOT4
  • YKL110C
    		•  The BioGRID Database Seperator Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Frohloff F (2003) [10]
    bait Fichtner L (2002) [6]
    Co-fractionation
    bait Fichtner L (2002) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IKI3
  • TOT1
  • ELP1
  • YLR384C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
    Gene Ontology: [View List]
    Co-purification
    hit Otero G (1999) [5]
    bait Greenwood C (2009) [11]
    Co-fractionation
    bait Fichtner L (2003) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB2
  • HRS2
  • MED20
  • YHR041C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Thompson CM (1993) [12]
    Synthetic Rescue
    hit Koleske AJ (1992) [1]
    hit Nonet ML (1989) [1]
    Phenotypic Enhancement
    hit Malagon F (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT6
  • SSN20
  • CRE2
  • YGR116W
    		•  The BioGRID Database Seperator Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004) [890]
    hit Krogan NJ (2002) [90]
    Synthetic Growth Defect
    bait Kaplan CD (2005) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAF1
  • YBR279W
    		•  The BioGRID Database Seperator RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2002) [90]
    Affinity Capture-Western
    bait Shi X (1997) [13]
    Synthetic Lethality
    hit Chu Y (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL4
  • GAL81
  • YPL248C
    		•  The BioGRID Database Seperator DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
    Gene Ontology: [View List]
    Co-localization
    bait Bhaumik SR (2001) [7]
    Phenotypic Enhancement
    hit Allison LA (1989) [2]
    Phenotypic Suppression
    bait Allison LA (1989) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFC4
  • PCF1
  • YGR047C
    		•  The BioGRID Database Seperator One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Barilla D (2001) [5]
    Reconstituted Complex
    hit Barilla D (2001) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRR25
  • YPL204W
    		•  The BioGRID Database Seperator Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Phatnani HP (2004) [10]
    Reconstituted Complex
    hit Phatnani HP (2004) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNA15
  • YGL044C
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Barilla D (2001) [5]
    Two-hybrid
    bait Barilla D (2001) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPN1
  • IWS1
  • YPR133C
    		•  The BioGRID Database Seperator Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2002) [90]
    Affinity Capture-Western
    bait/hit Zhang L (2008) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CET1
  • CES5
  • YPL228W
    		•  The BioGRID Database Seperator Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Cho EJ (1997) [2]
    hit Cho EJ (1998) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTK1
  • YKL139W
    		•  The BioGRID Database Seperator Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
    Gene Ontology: [View List]
    Biochemical Activity
    bait Keogh MC (2003) [7]
    hit Max T (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE2
  • CPS60
  • YLR015W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wood A (2003) [2]
    bait Dehe PM (2006) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABD1
  • YBR236C
    		•  The BioGRID Database Seperator Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Schroeder SC (2000) [2]
    Affinity Capture-Western
    hit McCracken S (1997) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC5
  • YDR059C
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
    Gene Ontology: [View List]
    Biochemical Activity
    bait Somesh BP (2005) [4]
    Affinity Capture-Western
    bait Somesh BP (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSD1
  • CLA1
  • MCS1
  • SRK1
  • YDR293C
    		•  The BioGRID Database Seperator Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Phatnani HP (2004) [10]
    Reconstituted Complex
    hit Phatnani HP (2004) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CFT2
  • YDH1
  • YLR115W
    		•  The BioGRID Database Seperator Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Kyburz A (2003) [17]
    Two-hybrid
    hit Kyburz A (2003) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTR9
  • CDP1
  • YOL145C
    		•  The BioGRID Database Seperator Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Mueller CL (2002) [20]
    Synthetic Lethality
    hit Chu Y (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASK10
  • YGR097W
    		•  The BioGRID Database Seperator Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Cohen TJ (2003) [4]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSU72
  • YNL222W
    		•  The BioGRID Database Seperator Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo
    Gene Ontology: [View List]
    Protein-peptide
    bait Krishnamurthy S (2004) [1]
    Synthetic Rescue
    bait Reyes-Reyes M (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • SRM5
  • HSL5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
    Gene Ontology: [View List]
    Co-localization
    bait Cosma MP (2001) [8]
    Synthetic Lethality
    hit Drebot MA (1993) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP6
  • YOR001W
    		•  The BioGRID Database Seperator Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004) [890]
    Phenotypic Enhancement
    hit Vasiljeva L (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT21
  • YMR179W
    		•  The BioGRID Database Seperator Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Phenotypic Enhancement
    hit Malagon F (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSF1
  • YLR087C
    		•  The BioGRID Database Seperator Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAH1
  • YCR060W
    		•  The BioGRID Database Seperator HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • SDI1
  • SDS16
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP30
  • YMR263W
    		•  The BioGRID Database Seperator Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAS2
  • CYR3
  • CTN5
  • TSL7
  • YNL098C
    		•  The BioGRID Database Seperator GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
    Gene Ontology: [View List]
    Dosage Lethality
    hit Howard SC (2002) [6]
    Synthetic Lethality
    bait Howard SC (2003) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gong Y (2009) [1420]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHG1
  • CPS15
  • YBR258C
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Dehe PM (2006) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWT1
  • YOR166C
    		•  The BioGRID Database Seperator Protein of unknown function; involved in transcription associated process; interacts genetically and physically with the TREX complex and RNA polymerase II; contains a PINc domain (PilT N terminus); localizes in the nucleus
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Roether S (2006) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFO1
  • YML088W
    		•  The BioGRID Database Seperator F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baranes-Bachar K (2008) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP8
  • YMR223W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wyce A (2007) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT6
  • TCP6
  • TCP20
  • HTR3
  • YDR188W
    		•  The BioGRID Database Seperator Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Dekker C (2008) [179]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI3
  • YNL197C
    		•  The BioGRID Database Seperator RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
    Gene Ontology: [View List]
    Protein-RNA
    bait Colomina N (2008) [318]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBQ1
  • HAPLESS 4
  • EMBRYO DE...
  • F3C22.8
  • At3g52590
    		•  The BioGRID Database Seperator UBQ1 (UBIQUITIN EXTENSION PROTEIN 1); protein binding / structural constituent of ribosome
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ling R (2000) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSL1
  • YLR005W
    		•  The BioGRID Database Seperator Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Max T (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUS1
  • YBR111W-A
    		•  The BioGRID Database Seperator Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pascual-Garcia P (2008) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCL1
  • YPR025C
    		•  The BioGRID Database Seperator Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
    Gene Ontology: [View List]
    Biochemical Activity
    hit Akhtar MS (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF1
  • TAF130
  • TAF145
  • YGR274C
    		•  The BioGRID Database Seperator TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
    Gene Ontology: [View List]
    Co-localization
    bait Ohtsuki K (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STH1
  • NPS1
  • YIL126W
    		•  The BioGRID Database Seperator ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Soutourina J (2006) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD3
  • REM1
  • YER171W
    		•  The BioGRID Database Seperator 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein
    Gene Ontology: [View List]
    Biochemical Activity
    hit Akhtar MS (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSL2
  • LOM3
  • RAD25
  • YIL143C
    		•  The BioGRID Database Seperator Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3
    Gene Ontology: [View List]
    Biochemical Activity
    hit Akhtar MS (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN8
  • UME3
  • NUT9
  • RYE2
  • YNL025C
    		•  The BioGRID Database Seperator Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
    Gene Ontology: [View List]
    Biochemical Activity
    hit Akhtar MS (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLT2
  • BYC2
  • MPK1
  • SLK2
  • YHR030C
    		•  The BioGRID Database Seperator Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
    Gene Ontology: [View List]
    Biochemical Activity
    hit Akhtar MS (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOA2
  • YKL058W
    		•  The BioGRID Database Seperator TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Liu Y (2009) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THP1
  • BUD29
  • YOL072W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pascual-Garcia P (2008) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNQ1
  • YCL028W
    		•  The BioGRID Database Seperator [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Tipton KA (2008) [53]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     clpB
  • ECK2590
  • htpM
  • JW2573
  • b2592
    		•  The BioGRID Database Seperator protein disaggregation chaperone
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Tipton KA (2008) [53]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chen X (2009) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADA2
  • SWI8
  • YDR448W
    		•  The BioGRID Database Seperator Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pascual-Garcia P (2008) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF1
  • VID21
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ginsburg DS (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTA7
  • YGR270W
    		•  The BioGRID Database Seperator Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lambert JP (2009) [269]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED8
  • YBR193C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Myers LC (1998) [46]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED4
  • YOR174W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Myers LC (1998) [46]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTA1
  • FUN39
  • YAL043C
    		•  The BioGRID Database Seperator Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Rodriguez CR (2000) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN4
  • ARG9
  • AAS3
  • YEL009C
    		•  The BioGRID Database Seperator Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Brandl CJ (1989) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAF1
  • YNL124W
    		•  The BioGRID Database Seperator Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
    Gene Ontology: [View List]
    Two-hybrid
    bait Fatica A (2002) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TLG2
  • YOL018C
    		•  The BioGRID Database Seperator Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chen HT (2003) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
    Gene Ontology: [View List]