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BioGRID | Network Layout for RPN5 for Saccharomyces cerevisiae
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RPN5

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: NAS5, YDL147W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RPN5

RPN5 was identified with 199 protein interactions and 24 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Isono E (2004) [10]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    hit Sharon M (2006) [3]
    Two-hybrid
    hit Fu H (2001) [13]
    hit Isono E (2005) [1]
    Co-purification
    bait Glickman MH (1998) [16]
    bait Saeki Y (2000) [9]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    Synthetic Rescue
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN11
  • MPR1
  • YFR004W
    		•  The BioGRID Database Seperator Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Isono E (2004) [10]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Taverner T (2008) [70]
    Two-hybrid
    hit Fu H (2001) [13]
    PCA
    hit Tarassov K (2008) [2616]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    bait Saeki Y (2009) [101]
    bait Taverner T (2008) [70]
    Synthetic Rescue
    bait Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN8
  • YOR261C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Isono E (2004) [10]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    hit Sharon M (2006) [3]
    Two-hybrid
    hit Fu H (2001) [13]
    PCA
    hit Tarassov K (2008) [2616]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    Synthetic Rescue
    bait Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN9
  • YDR427W
    		•  The BioGRID Database Seperator Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Isono E (2004) [10]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    hit Sharon M (2006) [3]
    Two-hybrid
    hit Fu H (2001) [13]
    PCA
    hit Tarassov K (2008) [2616]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN12
  • NIN1
  • YFR052W
    		•  The BioGRID Database Seperator Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    Synthetic Rescue
    hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN7
  • YPR108W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    bait Saeki Y (2009) [101]
    Synthetic Rescue
    bait Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Seong KM (2007) [75]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSN9
  • YDR179C
    		•  The BioGRID Database Seperator Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    hit Maytal-Kivity V (2003) [13]
    hit Cagney G (2001) [54]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN1
  • NAS1
  • HRD2
  • YHR027C
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    hit Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Co-purification
    bait Glickman MH (1998) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • YTA3
  • CIM5
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Synthetic Rescue
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT3
  • YTA2
  • YNT1
  • YDR394W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Synthetic Rescue
    hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT2
  • YTA5
  • YHS4
  • YDL007W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT5
  • YTA1
  • YOR117W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Funakoshi M (2009) [2]
    Synthetic Rescue
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • SCB68
  • CIM3
  • SUG1
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Synthetic Rescue
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN3
  • SUN2
  • YER021W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Verma R (2000) [85]
    hit Gavin AC (2006) [7592]
    Affinity Capture-Western
    bait Funakoshi M (2009) [33]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRI1
  • CSN5
  • JAB1
  • YDL216C
    		•  The BioGRID Database Seperator Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sone T (2004) [23]
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Funakoshi M (2009) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAS6
  • YGR232W
    		•  The BioGRID Database Seperator Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    bait Roelofs J (2009) [86]
    Affinity Capture-Western
    bait Saeki Y (2009) [101]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT4
  • PCS1
  • CRL13
  • SUG2
  • YOR259C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN13
  • YLR421C
    		•  The BioGRID Database Seperator Subunit of the 19S regulatory particle of the 26S proteasome lid
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCI8
  • YIH1
  • YIL071W
  • CSN11
  • YIL071C
    		•  The BioGRID Database Seperator Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM29
  • YHL030W
    		•  The BioGRID Database Seperator Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN2
  • SEN3
  • YIL075C
    		•  The BioGRID Database Seperator Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE2
  • SRR2
  • DOA3
  • PRG1
  • YPR103W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCL1
  • PRC2
  • YGL011C
    		•  The BioGRID Database Seperator Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE3
  • CRL21
  • YJL001W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE7
  • PRS3
  • YBL041W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    Synthetic Rescue
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE5
  • YMR314W
    		•  The BioGRID Database Seperator 20S proteasome alpha-type subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSM3
  • YBR272C
    		•  The BioGRID Database Seperator Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Le Tallec B (2009) [34]
    bait Saeki Y (2009) [101]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JSN1
  • PUF1
  • YJR091C
    		•  The BioGRID Database Seperator Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [1585]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN14
  • YGL004C
    		•  The BioGRID Database Seperator Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Affinity Capture-Western
    bait Saeki Y (2009) [101]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSI1
  • YMR025W
    		•  The BioGRID Database Seperator Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
    Gene Ontology: [View List]
    Two-hybrid
    hit Maytal-Kivity V (2003) [13]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRI2
  • CSN10
  • YOL117W
    		•  The BioGRID Database Seperator Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE6
  • YOL038W
    		•  The BioGRID Database Seperator 20S proteasome alpha-type subunit; green fluorescent protein (GFP)-fusion protein relocates from the cytosol to the mitochondrial outer surface upon oxidative stress
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR003C
  • YPR003C
    		•  The BioGRID Database Seperator Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NMD3
  • SRC5
  • YHR170W
    		•  The BioGRID Database Seperator Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SQT1
  • YIR012W
    		•  The BioGRID Database Seperator Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCP160
  • YJL080C
    		•  The BioGRID Database Seperator Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS13
  • SOI1
  • VPT2
  • YLL040C
    		•  The BioGRID Database Seperator Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IQG1
  • CYK1
  • YPL242C
    		•  The BioGRID Database Seperator Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPG5
  • YMR191W
    		•  The BioGRID Database Seperator Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL4
  • YCR014C
    		•  The BioGRID Database Seperator DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS18A
  • YDR450W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIP41
  • YPR040W
    		•  The BioGRID Database Seperator Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PST1
  • HPF2
  • YDR055W
    		•  The BioGRID Database Seperator Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPT1
  • YOR209C
    		•  The BioGRID Database Seperator Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF11
  • YDR073W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
    Gene Ontology: [View List]
    Two-hybrid
    hit Cagney G (2001) [54]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDH2
  • YOL126C
    		•  The BioGRID Database Seperator Cytoplasmic malate dehydrogenase, one of the three isozymes that catalyze interconversion of malate and oxaloacetate; involved in gluconeogenesis during growth on ethanol or acetate as carbon source; interacts with Pck1p and Fbp1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWA2
  • AUX1
  • BUD24
  • YDR320C
    		•  The BioGRID Database Seperator Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA4
  • NPI2
  • SSV7
  • MUT4
  • YDR069C
    		•  The BioGRID Database Seperator Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
    Gene Ontology: [View List]
    Two-hybrid
    hit Cagney G (2001) [54]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD32
  • LDB14
  • YGR262C
    		•  The BioGRID Database Seperator Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KRE6
  • CWH48
  • YPR159W
    		•  The BioGRID Database Seperator Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG12
  • APG12
  • YBR217W
    		•  The BioGRID Database Seperator Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EMP24
  • BST2
  • YGL200C
    		•  The BioGRID Database Seperator Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KGD1
  • OGD1
  • YIL125W
    		•  The BioGRID Database Seperator Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKS1
  • SHA3
  • YPL026C
    		•  The BioGRID Database Seperator Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
    Gene Ontology: [View List]
    Two-hybrid
    hit Cagney G (2001) [54]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC19
  • YDR201W
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC18
  • ANU4
  • YBR080C
    		•  The BioGRID Database Seperator ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAT1
  • AAA1
  • YDL040C
    		•  The BioGRID Database Seperator Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Kimura Y (2003) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX5
  • HEX3
  • YDL013W
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSG1
  • MUM1
  • TRS85
  • YDR108W
    		•  The BioGRID Database Seperator Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBL054W
  • YBL054W
    		•  The BioGRID Database Seperator Protein of unknown function involved in rRNA and ribosome biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BPH1
  • YCR032W
    		•  The BioGRID Database Seperator PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV46
  • FUN9
  • YAL042W
    		•  The BioGRID Database Seperator Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFC3
  • FUN24
  • TSV115
  • YAL001C
    		•  The BioGRID Database Seperator Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTL1
  • YCR020W-B
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FUN30
  • YAL019W
    		•  The BioGRID Database Seperator Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE4
  • YFR050C
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PUP1
  • YOR157C
    		•  The BioGRID Database Seperator Endopeptidase with trypsin-like activity that cleaves after basic residues; beta-type subunit of 20S proteasome synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE9
  • YGR135W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; the only nonessential 20S subunit
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE8
  • YML092C
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PUP2
  • DOA5
  • YGR253C
    		•  The BioGRID Database Seperator Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE10
  • YOR362C
    		•  The BioGRID Database Seperator 20S proteasome alpha-type subunit
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Breslow DK (2008) [591]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.