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BioGRID | Network Layout for RPN5 for Saccharomyces cerevisiae
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RPN5

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: NAS5, YDL147W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p|Rpn5p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RPN5

RPN5 was identified with 177 protein interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion|Rpn6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Gavin AC (2002)
    hit Ho Y (2002)
    hit Isono E (2004)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    hit Sharon M (2006)
    Two-hybrid
    hit Fu H (2001)
    hit Isono E (2005)
    Co-purification
    bait Glickman MH (1998)
    bait Saeki Y (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN9
  • YDR427W
    		•  The BioGRID Database Seperator Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects|Rpn9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Ho Y (2002)
    hit Isono E (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    hit Sharon M (2006)
    Two-hybrid
    hit Fu H (2001)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN8
  • YOR261C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p|Rpn8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Ho Y (2002)
    hit Isono E (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    hit Sharon M (2006)
    Two-hybrid
    hit Fu H (2001)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN11
  • MPR1
  • YFR004W
    		•  The BioGRID Database Seperator Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates|Rpn11p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Isono E (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    hit Fu H (2001)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN1
  • HRD2
  • NAS1
  • YHR027C
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions|Rpn1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Ho Y (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Co-purification
    bait Glickman MH (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSN9
  • YDR179C
    		•  The BioGRID Database Seperator Csn9p|Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000)
    hit Maytal-Kivity V (2003)
    hit Cagney G (2001)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    bait Seong KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN12
  • NIN1
  • YFR052W
    		•  The BioGRID Database Seperator Rpn12p|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Ho Y (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT3
  • YNT1
  • YTA2
  • YDR394W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B|Rpt3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Ho Y (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT2
  • YHS4
  • YTA5
  • YDL007W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle|Rpt2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Ho Y (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • CIM3
  • CRL3
  • SCB68
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle|Rpt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRI1
  • CSN5
  • JAB1
  • YDL216C
    		•  The BioGRID Database Seperator Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling|Rri1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT5
  • YTA1
  • YOR117W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription|Rpt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT4
  • CRL13
  • PCS1
  • SUG2
  • YOR259C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle|Rpt4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN7
  • YPR108W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits|Rpn7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN13
  • YLR421C
    		•  The BioGRID Database Seperator Rpn13p|Subunit of the 19S regulatory particle of the 26S proteasome lid; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN3
  • SUN2
  • YER021W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control|Rpn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM29
  • YHL030W
    		•  The BioGRID Database Seperator Ecm29p|Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle|Pre1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Verma R (2000)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCI8
  • CSN11
  • YIH1
  • YIL071W
  • YIL071C
    		•  The BioGRID Database Seperator Pci8p|Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN2
  • SEN3
  • YIL075C
    		•  The BioGRID Database Seperator Rpn2p|Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1|Sem1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sone T (2004)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAS6
  • YGR232W
    		•  The BioGRID Database Seperator Nas6p|Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSI1
  • YMR025W
    		•  The BioGRID Database Seperator Csi1p|Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Maytal-Kivity V (2003)
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRI2
  • CSN10
  • YOL117W
    		•  The BioGRID Database Seperator Rri2p|Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCL1
  • PRC2
  • YGL011C
    		•  The BioGRID Database Seperator Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria|Scl1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE5
  • YMR314W
    		•  The BioGRID Database Seperator 20S proteasome alpha-type subunit|Pre5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE7
  • PRS3
  • YBL041W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit|Pre7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE2
  • DOA3
  • PRG1
  • SRR2
  • YPR103W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome|Pre2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE3
  • CRL21
  • YJL001W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides|Pre3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NMD3
  • SRC5
  • YHR170W
    		•  The BioGRID Database Seperator Nmd3p|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator