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BioGRID | Network Layout for GCS1 for Saccharomyces cerevisiae
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GCS1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YDL226C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p|Gcs1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with GCS1

GCS1 was identified with 24 protein interactions and 68 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p|Arf1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Poon PP (1999)
    Affinity Capture-MS
    bait Trautwein M (2004)
    Two-hybrid
    bait/hit Liu YW (2005)
    bait Yahara N (2006)
    Reconstituted Complex
    bait Liu YW (2005)
    Synthetic Lethality
    bait Poon PP (1996)
    bait Zhang CJ (2003)
    hit Robinson M (2006)
    Dosage Lethality
    bait Zhang CJ (2003)
    Dosage Rescue
    bait Zhang CJ (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL1
  • DLP2
  • YBR164C
    		•  The BioGRID Database Seperator Arl1p|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Liu YW (2005)
    Reconstituted Complex
    bait Liu YW (2005)
    Affinity Capture-Western
    bait Liu YW (2005)
    Biochemical Activity
    hit Liu YW (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNC2
  • YOR327C
    		•  The BioGRID Database Seperator Snc2p|Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    hit Robinson M (2006)
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC14
  • PIT1
  • YMR079W
    		•  The BioGRID Database Seperator Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs|Sec14p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Yanagisawa LL (2002)
    bait Li X (2002)
    Synthetic Rescue
    bait Li X (2002)
    Dosage Rescue
    hit Wong TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLO3
  • YER122C
    		•  The BioGRID Database Seperator ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p|Glo3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Zhang CJ (2003)
    hit Robinson M (2006)
    Dosage Rescue
    bait Lewis SM (2004)
    hit Wong TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AGE2
  • SAT2
  • YIL044C
    		•  The BioGRID Database Seperator ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif|Age2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Poon PP (2001)
    bait Zhang CJ (2003)
    hit Robinson M (2006)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC28
  • ANU2
  • YIL076W
    		•  The BioGRID Database Seperator Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth|Sec28p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT31
  • YPT8
  • YER031C
    		•  The BioGRID Database Seperator GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi|Ypt31p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Zhang CJ (2002)
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SED1
  • YDR077W
    		•  The BioGRID Database Seperator Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites|Sed1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Filipak M (1992)
    Synthetic Rescue
    hit Drebot MA (1987)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNX4
  • ATG24
  • CVT13
  • YJL036W
    		•  The BioGRID Database Seperator Snx4p|Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SED5
  • YLR026C
    		•  The BioGRID Database Seperator Sed5p|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Inadome H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHO1
  • SSU81
  • YER118C
    		•  The BioGRID Database Seperator Sho1p|Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • EG375
    		•  The BioGRID Database Seperator ADP-ribosylation factor 1
    Gene Ontology: [View List]
    Two-hybrid
    hit Eugster A (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Blader IJ (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNA3
  • YJL151C
    		•  The BioGRID Database Seperator Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting|Sna3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIP1
  • YGR172C
    		•  The BioGRID Database Seperator Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles|Yip1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIP4
  • YGL198W
    		•  The BioGRID Database Seperator Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport|Yip4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS68
  • YOL129W
    		•  The BioGRID Database Seperator Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria|Vps68p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TVP38
  • YKR088C
    		•  The BioGRID Database Seperator Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern|Tvp38p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPM1
  • SED3
  • YPR183W
    		•  The BioGRID Database Seperator Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation|Dpm1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIS1
  • YPR113W
    		•  The BioGRID Database Seperator Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins|Pis1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YSA1
  • RMA2
  • YBR111C
    		•  The BioGRID Database Seperator Nudix hydrolase family member with ADP-ribose pyrophosphatase activity|Ysa1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSR1
  • SFH2
  • YLR380W
    		•  The BioGRID Database Seperator Csr1p|Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Wong TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEL048C
  • YEL048C
    		•  The BioGRID Database Seperator Putative protein of unknown function; synthetic lethal with gcs1delta|Yel048cp; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGL081W
  • YGL081W
    		•  The BioGRID Database Seperator Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis|Ygl081wp; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • SPO15
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis|Vps1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA5
  • CSL5
  • VAT3
  • YKL080W
    		•  The BioGRID Database Seperator Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane|Vma5p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA6
  • YLR447C
    		•  The BioGRID Database Seperator Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane|Vma6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRS33
  • YOR115C
    		•  The BioGRID Database Seperator One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic|Trs33p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin|Ubp3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS51
  • API3
  • VPS67
  • WHI6
  • YKR020W
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p|Vps51p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC55
  • YGL190C
    		•  The BioGRID Database Seperator Cdc55p|Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at the bud neck and at the bud tip; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Wang X (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AGE1
  • SAT1
  • YDR524C
    		•  The BioGRID Database Seperator ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif|Age1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Wong TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC4
  • EAF2
  • GOD1
  • YGR002C
    		•  The BioGRID Database Seperator Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex|Swc4p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TLG2
  • YOL018C
    		•  The BioGRID Database Seperator Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation|Tlg2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Robinson M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGP1
  • YDR137W
    		•  The BioGRID Database Seperator Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC50
  • YCR094W
    		•