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BioGRID | Network Layout for SSB1 for Saccharomyces cerevisiae
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SSB1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YG101, YDL229W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p|Ssb1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SSB1

SSB1 was identified with 37 protein interactions and 22 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shaner L (2005)
    bait Yam AY (2005)
    Reconstituted Complex
    bait Shaner L (2005)
    Affinity Capture-MS
    bait Yam AY (2005)
    bait Raviol H (2006)
    Co-fractionation
    bait Yam AY (2005)
    Dosage Lethality
    hit Yam AY (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSB2
  • YG103
  • YNL209W
    		•  The BioGRID Database Seperator Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1|Ssb2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Gautschi M (2003)
    hit Yan W (1998)
    hit Nelson RJ (1992)
    Phenotypic Enhancement
    hit Kim SY (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP60
  • YAR002W
    		•  The BioGRID Database Seperator Nup60p|Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Denning D (2001)
    Affinity Capture-MS
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUP35
  • GST1
  • PNM2
  • SAL3
  • YDR172W
    		•  The BioGRID Database Seperator Sup35p|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Allen KD (2005)
    Affinity Capture-Western
    bait Allen KD (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zhao R (2005)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Yam AY (2005)
    Dosage Lethality
    hit Yam AY (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAT1
  • AAA1
  • YDL040C
    		•  The BioGRID Database Seperator Nat1p|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Gautschi M (2003)
    Synthetic Growth Defect
    bait Gautschi M (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome|Clb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Honey S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NMD3
  • SRC5
  • YHR170W
    		•  The BioGRID Database Seperator Nmd3p|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Kallstrom G (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP19
  • PSO4
  • YLL036C
    		•  The BioGRID Database Seperator Prp19p|Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Stevens SW (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR186C
  • YDR186C
    		•  The BioGRID Database Seperator Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm|Ydr186cp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP10
  • HMO2
  • YDL002C
    		•  The BioGRID Database Seperator Nhp10p|Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Morrison AJ (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCD6
  • LSM13
  • YPR129W
    		•  The BioGRID Database Seperator Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin|Scd6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Decourty L (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FES1
  • YBR101C
    		•  The BioGRID Database Seperator Fes1p|Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Dragovic Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF6
  • CDC95
  • YPR016C
    		•  The BioGRID Database Seperator Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits|Tif6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Graindorge JS (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT107
  • ESC4
  • YHR154W
    		•  The BioGRID Database Seperator Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition|Rtt107p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Roberts TM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTC4
  • GCT1
  • YBR125C
    		•  The BioGRID Database Seperator Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity|Ptc4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC110
  • NUF1
  • XCM1
  • YDR356W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner|Spc110p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Wigge PA (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL3
  • MTR13
  • MTS1
  • NAB1
  • YDR432W
    		•  The BioGRID Database Seperator Npl3p|RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hurt E (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP159
  • NUP158
  • RAT7
  • YIL115C
    		•  The BioGRID Database Seperator Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export|Nup159p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNL1
  • YIL016W
    		•  The BioGRID Database Seperator Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein|Snl1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Sondermann H (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSF1
  • EXA3
  • MAS3
  • YGL073W
    		•  The BioGRID Database Seperator Hsf1p|Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bonner JJ (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC6
  • YCR052W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p|Rsc6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baetz KK (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • CCR1
  • GLC2
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis|Snf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Elbing K (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REG1
  • HEX2
  • PZF240
  • SPP43
  • YDR028C
    		•  The BioGRID Database Seperator Reg1p|Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Dombek KM (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC8
  • SWH3
  • YFR037C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters|Rsc8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baetz KK (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAF1
  • YNL124W
    		•  The BioGRID Database Seperator Naf1p|Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Yang PK (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP2
  • YLR335W
    		•  The BioGRID Database Seperator Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization|Nup2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP1
  • YOR098C
    		•  The BioGRID Database Seperator Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate|Nup1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRA1
  • SHE11
  • YDR381W
    		•  The BioGRID Database Seperator Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function|Yra1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Kashyap AK (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain|Yaf9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zhang H (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE9
  • YGR135W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; the only nonessential 20S subunit|Pre9p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Ohba M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP8
  • DBF3
  • DNA39
  • RNA8
  • YHR165C
    		•  The BioGRID Database Seperator Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa|Prp8p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Shea JE (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TCP1
  • CCT1
  • YDR212W
    		•  The BioGRID Database Seperator Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide|Tcp1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Siegers K (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE8
  • YML092C
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit|Pre8p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Ohba M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR1
  • YJR110W
    		•  The BioGRID Database Seperator Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family|Ymr1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait/hit Parrish WR (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GWT1
  • YJL091C
    		•  The BioGRID Database Seperator Gwt1p|Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Okamoto M (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP104
  • YLL026W
    		•  The BioGRID Database Seperator Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation|Hsp104p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Kushnirov VV (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIM18
  • YOR297C
    		•  The BioGRID Database Seperator Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex|Tim18p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Dunn CD (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARD1
  • YHR013C
    		•  The BioGRID Database Seperator Ard1p|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Gautschi M (2003)