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BioGRID | Network Layout for SEC31 for Saccharomyces cerevisiae
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SEC31

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: WEB1, YDL195W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation|Sec31p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 3 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SEC31

SEC31 was identified with 55 protein interactions and 9 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SEC13
  • ANU3
  • YLR208W
    		•  The BioGRID Database Seperator Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles|Sec13p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Ho Y (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    Affinity Capture-Western
    bait Antonny B (2003)
    hit Shaywitz DA (1997)
    Reconstituted Complex
    bait Lederkremer GZ (2001)
    hit Belden WJ (2001)
    Co-crystal Structure
    bait Fath S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC23
  • YPR181C
    		•  The BioGRID Database Seperator GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p|Sec23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    Affinity Capture-Western
    hit Shaywitz DA (1997)
    Co-fractionation
    bait Matsuoka K (2000)
    hit Kurihara T (2000)
    Dosage Lethality
    bait Salama NR (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC16
  • LPF1
  • YPL085W
    		•  The BioGRID Database Seperator COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p|Sec16p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shaywitz DA (1997)
    Two-hybrid
    bait Shaywitz DA (1997)
    Reconstituted Complex
    bait Supek F (2002)
    Dosage Lethality
    bait Salama NR (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHR3
  • APF1
  • YDL212W
    		•  The BioGRID Database Seperator Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface|Shr3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gilstring CF (1999)
    Dosage Rescue
    hit Gilstring CF (1999)
    Synthetic Growth Defect
    bait Gilstring CF (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLP1
  • YOR250C
    		•  The BioGRID Database Seperator Clp1p|Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC24
  • ANU1
  • YIL109C
    		•  The BioGRID Database Seperator Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p|Sec24p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shaywitz DA (1997)
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BET1
  • SLY12
  • YIL004C
    		•  The BioGRID Database Seperator Bet1p|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Springer S (1998)
    Co-fractionation
    hit Kurihara T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPP2B
  • RPL45
  • YPA1
  • YDR382W
    		•  The BioGRID Database Seperator Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm|Rpp2bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP2
  • YNL112W
    		•  The BioGRID Database Seperator Dbp2p|Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRPS28
  • YDR337W
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the small subunit|Mrps28p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFB3
  • LST1
  • YHR098C
    		•  The BioGRID Database Seperator Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate|Sfb3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Roberg KJ (1999)
    bait/hit Roberg KJ (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL36B
  • YPL249C-A
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA|Rpl36bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL25
  • YOL127W
    		•  The BioGRID Database Seperator Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif|Rpl25p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL43A
  • YPR043W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype|Rpl43ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL31A
  • RPL34
  • YDL075W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p|Rpl31ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL33B
  • YOR234C
    		•  The BioGRID Database Seperator Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable|Rpl33bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS24B
  • RPS24EB
  • YIL069C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein|Rps24bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STM1
  • MPT4
  • YLR150W
    		•  The BioGRID Database Seperator Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations|Stm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL18A
  • RP28A
  • YOL120C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation|Rpl18ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL13A
  • YDL082W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein|Rpl13ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS18A
  • YDR450W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins|Rps18ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL6A
  • YL16A
  • YML073C
    		•  The BioGRID Database Seperator N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA|Rpl6ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR2
  • GRP78
  • YJL034W
    		•  The BioGRID Database Seperator ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p|Kar2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRN1
  • YLR429W
    		•  The BioGRID Database Seperator Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity|Crn1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB1
  • YGL019W
    		•  The BioGRID Database Seperator Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases|Ckb1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA2
  • YOR29-12
  • YOR061W
    		•  The BioGRID Database Seperator Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKA1
  • YIL035C
    		•  The BioGRID Database Seperator Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMD2
  • PUR5
  • YHR216W
    		•  The BioGRID Database Seperator Imd2p|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EMP24
  • BST2
  • YGL200C
    		•  The BioGRID Database Seperator Emp24p|Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Belden WJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL7A
  • YGL076C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)|Rpl7ap; ncRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV25
  • YML012W
    		•  The BioGRID Database Seperator Erv25p|Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Belden WJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL10
  • GRC5
  • QSR1
  • YLR075W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family|Rpl10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC22
  • SLY2
  • TSL26
  • YLR268W
    		•  The BioGRID Database Seperator R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog|Sec22p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Kurihara T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP84
  • YDL116W
    		•  The BioGRID Database Seperator Nup84p|Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Siniossoglou S (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIP1
  • YGR172C
    		•  The BioGRID Database Seperator Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles|Yip1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Chen CZ (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG3
  • GRD20
  • SEC34
  • YER157W
    		•  The BioGRID Database Seperator Cog3p|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Kim DW (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Higashio H (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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