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BioGRID | Network Layout for CDC13 for Saccharomyces cerevisiae
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CDC13

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: EST4, YDL220C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 11 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CDC13

CDC13 was identified with 65 protein interactions and 496 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 STN1
  • YDR082W
    		•  The BioGRID Database Seperator Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    hit Chandra A (2001) [3]
    bait/hit Grandin N (2001) [8]
    bait/hit Grandin N (2001) [4]
    bait/hit Grandin N (1997) [3]
    hit Wang MJ (2000) [1]
    bait Petreaca RC (2006) [3]
    bait Lin YC (2007) [1]
    bait Petreaca RC (2007) [9]
    hit Yu H (2008) [1778]
    hit Puglisi A (2008) [5]
    bait Puglisi A (2008) [7]
    Affinity Capture-Western
    hit Qian W (2009) [6]
    hit Li S (2009) [8]
    Dosage Lethality
    hit Grandin N (2000) [5]
    Dosage Rescue
    hit Chandra A (2001) [3]
    Synthetic Lethality
    bait Grandin N (1997) [3]
    Phenotypic Enhancement
    hit Li S (2009) [8]
    Phenotypic Suppression
    hit Li S (2009) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD9
  • YDR217C
    		•  The BioGRID Database Seperator DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Maringele L (2002) [6]
    hit Grandin N (2001) [5]
    hit Downey M (2006) [17]
    hit Addinall SG (2008) [386]
    hit Grandin N (2008) [21]
    Synthetic Lethality
    bait Blankley RT (2004) [5]
    hit Foster SS (2006) [6]
    Phenotypic Suppression
    hit Garvik B (1995) [2]
    hit Zubko MK (2004) [6]
    hit Weber L (1992) [1]
    Synthetic Growth Defect
    hit Vodenicharov MD (2006) [1]
    hit Addinall SG (2008) [386]
    Phenotypic Enhancement
    hit Garvik B (1995) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST1
  • YLR233C
    		•  The BioGRID Database Seperator TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Qi H (2000) [8]
    bait Meier B (2001) [4]
    hit Li S (2009) [8]
    Two-hybrid
    hit Qi H (2000) [8]
    Dosage Rescue
    hit Qi H (2000) [8]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    Phenotypic Suppression
    hit Li S (2009) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEN1
  • YLR010C
    		•  The BioGRID Database Seperator Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
    Gene Ontology: [View List]
    Two-hybrid
    bait Grandin N (2001) [8]
    bait Xu L (2009) [7]
    Affinity Capture-Western
    bait/hit Qian W (2009) [6]
    Reconstituted Complex
    hit Qian W (2009) [6]
    Dosage Rescue
    hit Grandin N (2001) [8]
    Synthetic Lethality
    bait Xu L (2009) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Qi H (2000) [8]
    Two-hybrid
    hit Qi H (2000) [8]
    hit Hsu CL (2004) [12]
    hit Tseng SF (2006) [3]
    Synthetic Growth Defect
    hit Xu L (2009) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC1
  • ESR1
  • SAD3
  • YBR136W
    		•  The BioGRID Database Seperator Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
    Gene Ontology: [View List]
    Biochemical Activity
    bait Tseng SF (2006) [3]
    bait Tseng SF (2009) [2]
    Synthetic Rescue
    hit Grandin N (2001) [5]
    hit Grandin N (2008) [21]
    Synthetic Growth Defect
    hit Grandin N (2008) [21]
    Phenotypic Enhancement
    hit Zhang T (2009) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Synthetic Rescue
    hit Grandin N (2001) [5]
    hit Liang F (2007) [7]
    hit Tsolou A (2007) [10]
    hit Grandin N (2008) [21]
    Synthetic Growth Defect
    hit Grandin N (2008) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU70
  • HDF1
  • NES24
  • YMR284W
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Grandin N (2003) [1]
    Synthetic Lethality
    hit Nugent CI (1998) [4]
    bait Polotnianka RM (1998) [2]
    bait Meier B (2001) [4]
    Synthetic Rescue
    hit Grandin N (2000) [5]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU80
  • HDF2
  • YMR106C
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Polotnianka RM (1998) [2]
    bait Gravel S (1998) [1]
    hit Vega LR (2007) [5]
    bait Meier B (2001) [4]
    Synthetic Rescue
    hit Grandin N (2000) [5]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Grandin N (2001) [5]
    hit Addinall SG (2008) [386]
    Phenotypic Suppression
    hit Zubko MK (2004) [6]
    hit Small VY (2008) [2]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    Phenotypic Enhancement
    hit Small VY (2008) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS2
  • CES4
  • YML109W
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Hsu CL (2004) [12]
    Reconstituted Complex
    hit Hsu CL (2004) [12]
    Affinity Capture-Western
    hit Hsu CL (2004) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMP4
  • YNL075W
    		•  The BioGRID Database Seperator Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
    Gene Ontology: [View List]
    Two-hybrid
    hit Hsu CL (2004) [12]
    Reconstituted Complex
    hit Hsu CL (2004) [12]
    Affinity Capture-Western
    hit Hsu CL (2004) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Co-localization
    bait Visintin R (2001) [6]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    bait Mah AS (2005) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIF1
  • TST1
  • YML061C
    		•  The BioGRID Database Seperator DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Downey M (2006) [17]
    hit Vega LR (2007) [5]
    hit Smith S (2008) [10]
    hit Addinall SG (2008) [386]
    Dosage Lethality
    hit Vega LR (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO1
  • DHS1
  • YOR033C
    		•  The BioGRID Database Seperator 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Zubko MK (2004) [6]
    Synthetic Growth Defect
    bait Zubko MK (2004) [6]
    Synthetic Rescue
    hit Tsolou A (2007) [10]
    hit Addinall SG (2008) [386]
    hit Grandin N (2008) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIR4
  • STE9
  • ASD1
  • UTH2
  • YDR227W
    		•  The BioGRID Database Seperator Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
    Gene Ontology: [View List]
    Two-hybrid
    hit Hsu CL (2004) [12]
    Reconstituted Complex
    hit Hsu CL (2004) [12]
    Synthetic Growth Defect
    hit Greenall A (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHK1
  • YBR274W
    		•  The BioGRID Database Seperator Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Liang F (2007) [7]
    hit Addinall SG (2008) [386]
    hit Grandin N (2008) [21]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Downey M (2006) [17]
    hit Addinall SG (2008) [386]
    hit Grandin N (2008) [21]
    Dosage Rescue
    hit Grandin N (2008) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRC1
  • YCL060C
  • YCL061C
    		•  The BioGRID Database Seperator S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Grandin N (2007) [7]
    hit Tsolou A (2007) [10]
    hit Addinall SG (2008) [386]
    Dosage Rescue
    bait Grandin N (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEL1
  • YBL088C
    		•  The BioGRID Database Seperator Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
    Gene Ontology: [View List]
    Biochemical Activity
    bait Tseng SF (2006) [3]
    Phenotypic Enhancement
    bait Meier B (2001) [4]
    Synthetic Rescue
    hit Grandin N (2000) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STM1
  • MPT4
  • YLR150W
    		•  The BioGRID Database Seperator Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
    Gene Ontology: [View List]
    Two-hybrid
    hit Hayashi N (2002) [3]
    Dosage Rescue
    hit Hayashi N (2002) [3]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • SRM5
  • HSL5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
    Gene Ontology: [View List]
    Biochemical Activity
    bait Tseng SF (2009) [2]
    hit Li S (2009) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DDC1
  • YPL194W
    		•  The BioGRID Database Seperator DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Lin J (2004) [2]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Grandin N (2000) [5]
    Synthetic Growth Defect
    hit Foster SS (2006) [6]
    Synthetic Lethality
    hit Foster SS (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAN1
  • YDR143C
    		•  The BioGRID Database Seperator Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Gardner RG (2005) [5]
    Synthetic Rescue
    hit Downey M (2006) [17]
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC15
  • LYT1
  • YAR019C
    		•  The BioGRID Database Seperator Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    Synthetic Lethality
    hit Foster SS (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EDE1
  • BUD15
  • YBL047C
    		•  The BioGRID Database Seperator Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWS2
  • YNL081C
    		•  The BioGRID Database Seperator Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EBS1
  • YDR206W
    		•  The BioGRID Database Seperator Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Downey M (2006) [17]
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Zubko MK (2004) [6]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CGI121
  • YML036W
    		•  The BioGRID Database Seperator Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Downey M (2006) [17]
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP3
  • YGL078C
    		•  The BioGRID Database Seperator Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD32
  • LDB14
  • YGR262C
    		•  The BioGRID Database Seperator Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Downey M (2006) [17]
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIF2
  • YLR453C
    		•  The BioGRID Database Seperator Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Phenotypic Enhancement
    hit Li S (2009) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKI3
  • SKI5
  • YPR189W
    		•  The BioGRID Database Seperator Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS21
  • YPT21
  • YPT51
  • VPS12
  • YOR089C
    		•  The BioGRID Database Seperator GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUM2
  • YBR057C
    		•  The BioGRID Database Seperator Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASE1
  • YOR29-09
  • YOR058C
    		•  The BioGRID Database Seperator Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    Phenotypic Suppression
    bait Liu H (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHE4
  • DIM1
  • YOR035C
    		•  The BioGRID Database Seperator Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UTH1
  • YKR042W
    		•  The BioGRID Database Seperator Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPT1
  • YOR209C
    		•  The BioGRID Database Seperator Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    hit Greenall A (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS2
  • YMR127C
    		•  The BioGRID Database Seperator Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    Synthetic Rescue
    hit Kozak ML (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • YOR368W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR1
  • YML121W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BFA1
  • IBD1
  • YJR053W
    		•  The BioGRID Database Seperator Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Liang F (2007) [7]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS4
  • YDR181C
    		•  The BioGRID Database Seperator Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS1
  • GGP1
  • CWH52
  • YMR307W
    		•  The BioGRID Database Seperator Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC3
  • PSO9
  • PIP3
  • YLR288C
    		•  The BioGRID Database Seperator DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Grandin N (2001) [5]
    hit Grandin N (2008) [21]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NMD2
  • IFS1
  • SUA1
  • UPF2
  • YHR077C
    		•  The BioGRID Database Seperator Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Enomoto S (2004) [5]
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Qi H (2003) [3]
    hit Foster SS (2006) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDS1
  • YDR113C
    		•  The BioGRID Database Seperator Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Yamamoto A (1996) [4]
    Synthetic Rescue
    hit Liang F (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KSP1
  • YHR082C
    		•  The BioGRID Database Seperator Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRR2
  • YDL214C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCK1
  • YGL158W
    		•  The BioGRID Database Seperator Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR1
  • CPH1
  • CYP1
  • YDR155C
    		•  The BioGRID Database Seperator Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRK1
  • PAK1
  • YIL095W
    		•  The BioGRID Database Seperator Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM10
  • SSC3
  • YEL030W
    		•  The BioGRID Database Seperator Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD31
  • CWC14
  • YCR063W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Masciadri B (2004) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL150W
  • YPL150W
    		•  The BioGRID Database Seperator Putative protein kinase of unknown cellular role
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC13
  • EST4
  • YDL220C
    		•  The BioGRID Database Seperator Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Qian W (2009) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • PAS14
  • HAF3
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCK1
  • LAS3
  • SSP31
  • SAP3
  • YJL095W
    		•  The BioGRID Database Seperator Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG1
  • CVT10
  • APG1
  • AUT3
  • YGL180W
    		•  The BioGRID Database Seperator Protein serine/threonine kinase, required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; forms a complex with Atg13p and Atg17p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FUN12
  • yIF2
  • YAL035W
    		•  The BioGRID Database Seperator GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
    Gene Ontology: [View List]
    Two-hybrid
    hit Qi H (2000) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IME2
  • SME1
  • YJL106W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC110
  • NUF1
  • XCM1
  • YDR356W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
    Gene Ontology: [View List]
    Co-purification
    bait Wigge PA (1998) [37]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK2
  • YNL154C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BAT1
  • TWT1
  • ECA39
  • YHR208W
    		•  The BioGRID Database Seperator Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADH4
  • ZRG5
  • NRC465
  • YGL256W
    		•  The BioGRID Database Seperator Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIM18
  • YOR297C
    		•  The BioGRID Database Seperator Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI3
  • YNL197C
    		•  The BioGRID Database Seperator RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YME2
  • PRP12
  • RNA12
  • YMR302C
    		•  The BioGRID Database Seperator Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT106
  • YNL206C
    		•  The BioGRID Database Seperator Protein with a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FYV4
  • YHR059W
    		•  The BioGRID Database Seperator Protein of unknown function, required for survival upon exposure to K1 killer toxin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL19B
  • YBL027W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC10
  • RKS2
  • PFD3
  • GIM2
  • YGR078C
    		•  The BioGRID Database Seperator Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INO4
  • YOL108C
    		•  The BioGRID Database Seperator Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LST4
  • YKL176C
    		•  The BioGRID Database Seperator Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PBI2
  • LMA1
  • YNL015W
    		•  The BioGRID Database Seperator Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PET8
  • SAM5
  • YNL003C
    		•  The BioGRID Database Seperator S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEF3
  • ZRG7
  • YNL014W
    		•  The BioGRID Database Seperator Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INP52
  • SJL2
  • YNL106C
    		•  The BioGRID Database Seperator Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS23A
  • YGR118W
    		•  The BioGRID Database Seperator Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APQ12
  • YIL040W
    		•  The BioGRID Database Seperator Protein involved in nucleocytoplasmic transport of mRNA
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMP2
  • YMR035W
    		•  The BioGRID Database Seperator Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GGA2
  • YHR108W
    		•  The BioGRID Database Seperator Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMP45
  • YDL222C
    		•  The BioGRID Database Seperator Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKS1
  • CWH53
  • GSC1
  • PBR1
  • YLR342W
    		•  The BioGRID Database Seperator Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEL2
  • YGR238C
    		•  The BioGRID Database Seperator Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSG2
  • CLS2
  • YBR036C
    		•  The BioGRID Database Seperator Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOP12
  • YOL041C
    		•  The BioGRID Database Seperator Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRP49
  • YKL167C
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET22
  • HAL2
  • YOL064C
    		•  The BioGRID Database Seperator Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DTD1
  • YDL219W
    		•  The BioGRID Database Seperator D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCC1
  • YCL016C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHR151C
  • YHR151C
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR128W
  • YDR128W
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR255W
  • YBR255W
    		•  The BioGRID Database Seperator Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGL226W
  • YGL226W
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO5
  • YBR093C
    		•  The BioGRID Database Seperator Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDL218W
  • YDL218W
    		•  The BioGRID Database Seperator Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHO2
  • PEM1
  • YGR157W
    		•  The BioGRID Database Seperator Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP188
  • YML103C
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCZ1
  • CVT16
  • YBR131W
    		•  The BioGRID Database Seperator Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKL098W
  • YKL098W
    		•  The BioGRID Database Seperator Putative protein of unknown function
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRM44
  • YPL030W
    		•  The BioGRID Database Seperator Putative tRNA U44 2'-O-methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TMA22
  • YJR014W
    		•  The BioGRID Database Seperator Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TMA20
  • YER007C-A
    		•  The BioGRID Database Seperator Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TKL1
  • YPR074C
    		•  The BioGRID Database Seperator Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIR3
  • YIB1
  • YIL011W
    		•  The BioGRID Database Seperator Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNA1
  • YGR260W
    		•  The BioGRID Database Seperator High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOM7
  • MOM7
  • YOK22
  • YNL070W
    		•  The BioGRID Database Seperator Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUS1
  • SOP10
  • YLR425W
    		•  The BioGRID Database Seperator Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRD1
  • YPA1
  • YIL153W
    		•  The BioGRID Database Seperator Activator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPM2
  • YIL138C
    		•  The BioGRID Database Seperator Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOM70
  • MAS70
  • MOM72
  • OMP1
  • YNL121C
    		•  The BioGRID Database Seperator Component (70 kDa) of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAL1
  • YLR354C
    		•  The BioGRID Database Seperator Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWA2
  • AUX1
  • BUD24
  • YDR320C
    		•  The BioGRID Database Seperator Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP2
  • YNL311C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKI8
  • REC103
  • YGL213C
    		•  The BioGRID Database Seperator Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKI7
  • YOR29-27
  • YOR076C
    		•  The BioGRID Database Seperator Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMI1
  • KNR4
  • YGR229C
    		•  The BioGRID Database Seperator Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT2
  • EXA1
  • SIN1
  • YER161C
    		•  The BioGRID Database Seperator Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSH1
  • YBR283C
    		•  The BioGRID Database Seperator Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSF1
  • YHR066W
    		•  The BioGRID Database Seperator Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SQS1
  • YNL224C
    		•  The BioGRID Database Seperator Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKE4
  • YIL023C
    		•  The BioGRID Database Seperator Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XBP1
  • YIL101C
    		•  The BioGRID Database Seperator Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS60
  • CHM5
  • MOS10
  • YDR486C
    		•  The BioGRID Database Seperator Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS51
  • VPS67
  • WHI6
  • API3
  • YKR020W
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMC2
  • YBR104W
    		•  The BioGRID Database Seperator Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPS7
  • YDR349C
    		•  The BioGRID Database Seperator Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLZ1
  • YNL196C
    		•  The BioGRID Database Seperator Sporulation-specific protein with a leucine zipper motif
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL123C
  • YJL123C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT7
  • AST4
  • VAM4
  • YML001W
    		•  The BioGRID Database Seperator GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS35
  • VPT7
  • GRD9
  • YJL154C
    		•  The BioGRID Database Seperator Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS30
  • ATG6
  • VPT30
  • APG6
  • YPL120W
    		•  The BioGRID Database Seperator Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URE2
  • YNL229C
    		•  The BioGRID Database Seperator Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD2
  • YDL190C
    		•  The BioGRID Database Seperator Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX7
  • CUI3
  • YBR273C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX4
  • CUI1
  • YMR067C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM6
  • VPL22
  • VPS39
  • CVT4
  • YDL077C
    		•  The BioGRID Database Seperator Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM7
  • VPS43
  • YGL212W
    		•  The BioGRID Database Seperator Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • VPL1
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID28
  • GID5
  • YIL017W
  • YIL017C
    		•  The BioGRID Database Seperator Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VHS2
  • YIL135C
    		•  The BioGRID Database Seperator Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CGR1
  • YGL029W
    		•  The BioGRID Database Seperator Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST3
  • YIL009C-A
    		•  The BioGRID Database Seperator Component of the telomerase holoenzyme, involved in telomere replication
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS21B
  • YJL136C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Addinall SG (2008) [386]