The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for SWD1 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

SWD1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CPS50, FUN16, SAF49, YAR003W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7|Swd1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 6 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SWD1

SWD1 was identified with 52 protein interactions and 143 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SET1
  • YTX1
  • YHR119W
    		•  The BioGRID Database Seperator Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain|Set1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Roguev A (2001)
    bait Miller T (2001)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    bait Dehe PM (2006)
    Affinity Capture-Western
    bait Nagy PL (2002)
    Co-purification
    bait Miller T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE2
  • CPS60
  • YLR015W
    		•  The BioGRID Database Seperator Bre2p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Roguev A (2001)
    bait Miller T (2001)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    bait Lee JS (2007)
    Affinity Capture-Western
    bait Lee JS (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD3
  • CPS30
  • SAF35
  • YBR175W
    		•  The BioGRID Database Seperator Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5|Swd3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Roguev A (2001)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    hit Nedea E (2008)
    Two-hybrid
    hit Uetz P (2000)
    Phenotypic Suppression
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPP1
  • CPS40
  • SAF41
  • YPL138C
    		•  The BioGRID Database Seperator Spp1p|Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Roguev A (2001)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    bait Dehe PM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SDC1
  • CPS25
  • SAF19
  • YDR469W
    		•  The BioGRID Database Seperator Sdc1p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Roguev A (2001)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD2
  • CPS35
  • SAF37
  • YKL018W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination|Swd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Roguev A (2001)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Laribee RN (2005)
    hit Laribee RN (2007)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA4
  • DOS1
  • MUT4
  • NPI2
  • YDR069C
    		•  The BioGRID Database Seperator Doa4p|Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHG1
  • CPS15
  • YBR258C
    		•  The BioGRID Database Seperator Shg1p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Roguev A (2001)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSM7
  • YJR113C
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein|Rsm7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion|Ctf4p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain|Yaf9p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • SON1
  • UFD5
  • YDL020C
    		•  The BioGRID Database Seperator Rpn4p|Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Laribee RN (2005)
    hit Laribee RN (2007)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin|Htz1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    Synthetic Growth Defect
    bait Venkatasubrahmanyam S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008)
    bait Lin YY (2008)
    Synthetic Lethality
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • BUR5
  • SIN2
  • YBR010W
    		•  The BioGRID Database Seperator Hht1p|One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Mueller JE (2006)
    Synthetic Growth Defect
    hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT4
  • YGR063C
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing|Spt4p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Laribee RN (2005)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps71p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS72
  • SWC2
  • YDR485C
    		•  The BioGRID Database Seperator Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps72p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1|Sem1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Laribee RN (2005)
    hit Laribee RN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swc5p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Laribee RN (2005)
    hit Laribee RN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion|Rpn6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    Synthetic Lethality
    hit Laribee RN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM39
  • GET1
  • YGL020C
    		•  The BioGRID Database Seperator Get1p|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID21
  • EAF1
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex|Eaf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008)
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swr1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD7
  • HUR2
  • GET2
  • YER083C
    		•  The BioGRID Database Seperator Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Arp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT2
  • YNL031C
    		•  The BioGRID Database Seperator Hht2p|One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Mueller JE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTQ2
  • YDR140W
    		•  The BioGRID Database Seperator Mtq2p|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNR2
  • CRT6
  • YJL026W
    		•  The BioGRID Database Seperator Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits|Rnr2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase|Clb5p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM2
  • SMX5
  • SNP3
  • YBL026W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA|Lsm2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail r