| Name |
Aliases |
 |
Description |
|
|
| PEP5 |
END1VAM1VPL9YMR231W |
|
Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p|Pep5p; protein coding
|
|
|
|
|
| VPS16 |
SVL6VAM9VPT16YPL045W |
|
Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages|Vps16p; protein coding
|
|
|
|
|
| VPS33 |
CLS14MET27PEP14YLR396C |
|
ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport|Vps33p; protein coding
|
|
|
|
|
| PEP3 |
VAM8VPS18VPT18YLR148W |
|
Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis|Pep3p; protein coding
|
|
|
|
|
| CDC73 |
YLR418C |
|
Cdc73p|Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; protein coding
|
|
|
|
|
| ESA1 |
TAS1YOR244W |
|
Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
|
|
|
|
|
| ASF1 |
CIA1YJL115W |
|
Asf1p|Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; protein coding
|
|
|
|
|
| SAP30 |
YMR263W |
|
Sap30p|Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance; protein coding
|
|
|
|
|
| LGE1 |
YPL055C |
|
Lge1p|Protein of unknown function; null mutant forms abnormally large cells; protein coding
|
|
|
|
|
| RIC1 |
YLR039C |
|
Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
|
|
|
|
|
| YPT6 |
YLR262C |
|
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
|
|
|
|
|
| GCN3 |
AAS2YKR026C |
|
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression|Gcn3p; protein coding
|
|
|
|
|
| SDS22 |
EGP1YKL193C |
|
Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis|Sds22p; protein coding
|
|
|
|
|
| VPS3 |
PEP6VPL3VPT17YDR495C |
|
Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase|Vps3p; protein coding
|
|
|
|
|
| ARP6 |
YLR085C |
|
Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Arp6p; protein coding
|
|
|
|
|
| BUD27 |
URI1YFL023W |
|
Bud27p|Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; protein coding
|
|
|
|
|
| RTT106 |
YNL206C |
|
Protein with a role in regulation of Ty1 transposition|Rtt106p; protein coding
|
|
|
|
|
| SWR1 |
YDR334W |
|
Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swr1p; protein coding
|
|
|
|
|
| WHI2 |
YOR043W |
|
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression|Whi2p; protein coding
|
|
|
|
|
| CPR7 |
YJR032W |
|
Cpr7p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein coding
|
|
|
|
|
| MMS1 |
RTT108SLM6YPR164W |
|
Mms1p|Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition; protein coding
|
|
|
|
|
| RPC11 |
YDR045C |
|
RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS|Rpc11p; protein coding
|
|
|
|
|
| RAD52 |
YML032C |
|
Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis|Rad52p; protein coding
|
|
|
|
|
| SPT2 |
EXA1SIN1YER161C |
|
Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins|Spt2p; protein coding
|
|
|
|
|
| VPS71 |
SWC6YML041C |
|
Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps71p; protein coding
|
|
|
|
|
| DST1 |
PPR2YGL043W |
|
Dst1p|General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; protein coding
|
|
|
|
|
| GBP2 |
RLF6YCL011C |
|
Gbp2p|Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro; protein coding
|
|
|
|
|
| SEC66 |
HSS1SEC71YBR171W |
|
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER|Sec66p; protein coding
|
|
|
|
|
| CKS1 |
YBR135W |
|
Cks1p|Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; protein coding
|
|
|
|
|
| VPS64 |
FAR9YDR200C |
|
Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane|Vps64p; protein coding
|
|
|
|
|
| BRE5 |
YNR051C |
|
Bre5p|Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; protein coding
|
|
|
|
|
| CAF40 |
YNL288W |
|
Caf40p|Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p; protein coding
|
|
|
|
|
| IES2 |
YNL215W |
|
Ies2p|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; protein coding
|
|
|
|
|
| PSH1 |
YOL054W |
|
Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein|Psh1p; protein coding
|
|
|
|
|
| RVS161 |
END6FUS7SPE161YCR009C |
|
Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress|Rvs161p; protein coding
|
|
|
|
|
| VPS72 |
SWC2YDR485C |
|
Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps72p; protein coding
|
|
|
|
|
| UBP3 |
YER151C |
|
Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin|Ubp3p; protein coding
|
|
|
|
|
| CKA2 |
YOR29-12YOR061W |
|
Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases|Cka2p; protein coding
|
|
|
|
|
| ORM2 |
YLR350W |
|
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum|Orm2p; protein coding
|
|
|
|
|
| SNF4 |
CAT3SCI1YGL115W |
|
Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis|Snf4p; protein coding
|
|
|
|
|
| SLM3 |
MTU1MTO2YDL033C |
|
Slm3p|tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF); protein coding
|
