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BioGRID | Network Layout for ERV46 for Saccharomyces cerevisiae
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ERV46

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: FUN9, YAL042W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Erv46p|Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with ERV46

ERV46 was identified with 18 protein interactions and 25 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ERV41
  • YML067C
    		•  The BioGRID Database Seperator Erv41p|Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    Affinity Capture-Western
    hit Otte S (2001)
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    PCA
    bait/hit Tarassov K (2008)
    Synthetic Growth Defect
    bait Otte S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERO1
  • YML130C
    		•  The BioGRID Database Seperator Ero1p|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OPI3
  • PEM2
  • YJR073C
    		•  The BioGRID Database Seperator Opi3p|Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD7
  • HUR2
  • GET2
  • YER083C
    		•  The BioGRID Database Seperator Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE20
  • YHL007C
    		•  The BioGRID Database Seperator Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases|Ste20p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SED5
  • YLR026C
    		•  The BioGRID Database Seperator Sed5p|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Inadome H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ROT2
  • GLS2
  • YBR229C
    		•  The BioGRID Database Seperator Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations|Rot2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Welsh LM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCK1
  • YGL158W
    		•  The BioGRID Database Seperator Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations|Rck1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC1
  • YJR010C-A
    		•  The BioGRID Database Seperator Spc1p|Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Millson SH (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERP1
  • YAR002C-A
    		•  The BioGRID Database Seperator Erp1p|Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    bait Otte S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN12
  • NIN1
  • YFR052W
    		•  The BioGRID Database Seperator Rpn12p|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion|Rpn6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN5
  • NAS5
  • YDL147W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p|Rpn5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAR1
  • YPL218W
    		•  The BioGRID Database Seperator GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport|Sar1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Otte S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPF1
  • COD1
  • PER9
  • PIO1
  • YEL031W
    		•  The BioGRID Database Seperator P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1|Spf1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC4
  • YBR082C
    		•  The BioGRID Database Seperator Ubc4p|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC22
  • SLY2
  • TSL26
  • YLR268W
    		•  The BioGRID Database Seperator R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog|Sec22p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC66
  • HSS1
  • SEC71
  • YBR171W
    		•  The BioGRID Database Seperator Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER|Sec66p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC28
  • ANU2
  • YIL076W
    		•  The BioGRID Database Seperator Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth|Sec28p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC1
  • RSD1
  • YKL212W
    		•  The BioGRID Database Seperator Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion|Sac1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INO4
  • YOL108C
    		•  The BioGRID Database Seperator Ino4p|Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • SON1
  • UFD5
  • YDL020C
    		•  The BioGRID Database Seperator Rpn4p|Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSF1
  • YLR087C
    		•  The BioGRID Database Seperator Csf1p|Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG4
  • YGL012W
    		•  The BioGRID Database Seperator C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol|Erg4p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPH2
  • CLS10
  • VMA12
  • YKL119C
    		•  The BioGRID Database Seperator Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)|Vph2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Welsh LM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA21
  • YGR105W
    		•  The BioGRID Database Seperator Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)|Vma21p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Welsh LM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA22
  • CEV1
  • VPH6
  • YHR060W
    		•  The BioGRID Database Seperator Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)|Vma22p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Welsh LM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BFR1
  • YOR198C
    		•  The BioGRID Database Seperator Bfr1p|Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ICE2
  • YIL090W
    		•  The BioGRID Database Seperator Ice2p|Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM39
  • GET1
  • YGL020C
    		•  The BioGRID Database Seperator Get1p|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCS7
  • FAH1
  • YMR272C
    		•  The BioGRID Database Seperator Scs7p|Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PER1
  • COS16
  • YCR044C
    		•  The BioGRID Database Seperator Per1p|Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAC1
  • ERN4
  • IRE15
  • YFL031W
    		•  The BioGRID Database Seperator Hac1p|bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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