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BioGRID | Network Layout for YPT6 for Saccharomyces cerevisiae
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YPT6

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YLR262C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with YPT6

YPT6 was identified with 49 protein interactions and 428 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 GDI1
  • SEC19
  • YER136W
    		•  The BioGRID Database Seperator GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins|Gdi1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Ho Y (2002)
    hit Krogan NJ (2006)
    bait Collins SR (2007)
    Two-hybrid
    hit Calero M (2002)
    PCA
    bait Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    hit Siniossoglou S (2000)
    Affinity Capture-Western
    hit Siniossoglou S (2000)
    Dosage Rescue
    bait Bensen ES (2001)
    bait Siniossoglou S (2000)
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS53
  • YJL029C
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting|Vps53p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Siniossoglou S (2001)
    hit Siniossoglou S (2005)
    Reconstituted Complex
    hit Siniossoglou S (2001)
    Affinity Capture-MS
    hit Siniossoglou S (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS52
  • SAC2
  • YDR484W
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin|Vps52p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Siniossoglou S (2001)
    hit Siniossoglou S (2005)
    Reconstituted Complex
    hit Siniossoglou S (2001)
    Affinity Capture-MS
    hit Siniossoglou S (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGM1
  • YJR134C
    		•  The BioGRID Database Seperator Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus|Sgm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Siniossoglou S (2001)
    hit Fridmann-Sirkis Y (2004)
    hit Siniossoglou S (2005)
    Affinity Capture-MS
    hit Siniossoglou S (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYS1
  • YJL004C
    		•  The BioGRID Database Seperator Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation|Sys1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Dosage Rescue
    hit Bensen ES (2001)
    hit Tsukada M (1996)
    hit Setty SR (2004)
    Phenotypic Enhancement
    bait Tsukada M (1996)
    Synthetic Growth Defect
    bait Tsukada M (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS54
  • CGP1
  • LUV1
  • TCS3
  • YDR027C
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p|Vps54p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Siniossoglou S (2001)
    hit Siniossoglou S (2005)
    Reconstituted Complex
    hit Siniossoglou S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GYP6
  • YJL044C
    		•  The BioGRID Database Seperator GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport|Gyp6p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Will E (2001)
    hit Tsukada M (1999)
    Biochemical Activity
    bait Strom M (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMH1
  • SYS3
  • YLR309C
    		•  The BioGRID Database Seperator Imh1p|Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Dosage Rescue
    hit Li B (1996)
    hit Tsukada M (1996)
    hit Setty SR (2004)
    Synthetic Growth Defect
    hit Tsukada M (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGP1
  • YDR137W
    		•  The BioGRID Database Seperator Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    hit Siniossoglou S (2000)
    Dosage Rescue
    bait Siniossoglou S (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL1
  • DLP2
  • YBR164C
    		•  The BioGRID Database Seperator Arl1p|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    hit Lafourcade C (2004)
    Dosage Rescue
    hit Bensen ES (2001)
    hit Setty SR (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin|Htz1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    Synthetic Growth Defect
    bait Venkatasubrahmanyam S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSD1
  • CLA1
  • MCS1
  • RLT1
  • YDR293C
    		•  The BioGRID Database Seperator Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence|Ssd1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Li B (1996)
    Synthetic Lethality
    hit Li B (1996)
    Synthetic Rescue
    hit Li B (1998)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLY1
  • YDR189W
    		•  The BioGRID Database Seperator Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex|Sly1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Bensen ES (2001)
    Synthetic Rescue
    hit Li B (1998)
    hit Li Y (2007)
    Synthetic Lethality
    hit Luo Z (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zhao R (2005)
    Synthetic Lethality
    bait Zhao R (2005)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIP1
  • YGR172C
    		•  The BioGRID Database Seperator Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles|Yip1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Calero M (2003)
    Synthetic Lethality
    bait Chen CZ (2004)
    bait Chen CZ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIP3
  • YNL044W
    		•  The BioGRID Database Seperator Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p|Yip3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Calero M (2002)
    Two-hybrid
    hit Calero M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDR1
  • GYP2
  • MIC1
  • YGR100W
    		•  The BioGRID Database Seperator Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function|Mdr1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Siniossoglou S (2001)
    Biochemical Activity
    bait Albert S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSB3
  • GYP3
  • YNL293W
    		•  The BioGRID Database Seperator GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth|Msb3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Albert S (1999)
    bait Albert S ()
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Cdc73p|Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Lge1p|Protein of unknown function; null mutant forms abnormally large cells; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae|Swc3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM39
  • GET1
  • YGL020C
    		•  The BioGRID Database Seperator Get1p|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps71p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swr1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE1
  • YDL074C
    		•  The BioGRID Database Seperator Bre1p|E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL3
  • YPL051W
    		•  The BioGRID Database Seperator Arl3p|GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    hit Lafourcade C (2004)
    Dosage Rescue
    hit Setty SR (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS35
  • GRD9
  • VPT7
  • YJL154C
    		•  The BioGRID Database Seperator Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval|Vps35p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Luo Z (2003)
    Synthetic Growth Defect
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • AGS3
  • TUP7
  • VAC5
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance|Pho80p; protein coding