| Name |
Aliases |
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Description |
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| EFB1 |
TEF5YAL003W |
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Efb1p|Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; ncRNA
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| TEF1 |
YPR080W |
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Tef1p|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; protein coding
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| TEF2 |
YBR118W |
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Tef2p|Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; protein coding
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| AOS1 |
RHC31YPR180W |
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Aos1p|Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; protein coding
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| YER049W |
TPA1 |
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Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability|Tpa1p; protein coding
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| HSC82 |
HSP90YMR186W |
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Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
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| TEF4 |
EFC1YKL081W |
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Tef4p|Translation elongation factor EF-1 gamma; ncRNA
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| FCY1 |
YPR062W |
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Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)|Fcy1p; protein coding
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| DIM1 |
CDH1YPL266W |
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Dim1p|Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; protein coding
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| YPT52 |
YKR014C |
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GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis|Ypt52p; protein coding
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| CDC16 |
YKL022C |
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Cdc16p|Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; protein coding
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| DBP8 |
YHR169W |
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Dbp8p|Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit; protein coding
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| APC5 |
RMC1YOR249C |
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Apc5p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
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| TCB1 |
YOR086C |
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Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact|Tcb1p; protein coding
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| HRD1 |
DER3YOL013C |
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Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
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| CAP2 |
YIL034C |
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Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches|Cap2p; protein coding
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| SYF2 |
NTC31YGR129W |
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Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression|Syf2p; protein coding
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| ACS2 |
YLR153C |
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Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions|Acs2p; protein coding
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| YLR072W |
YLR072W |
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Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene|Ylr072wp; protein coding
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| VPS4 |
CSC1DID6END13YPR173C |
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AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism|Vps4p; protein coding
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| STB3 |
YDR169C |
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Protein that binds Sin3p in a two-hybrid assay|Stb3p; protein coding
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| YLF2 |
YLF1YHL014C |
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Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies|Ylf2p; protein coding
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| MCK1 |
YPK1YNL307C |
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Mck1p|Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family; protein coding
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| ADH1 |
ADC1YOL086C |
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Adh1p|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; protein coding
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| PDC1 |
YLR044C |
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Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism|Pdc1p; protein coding
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| EFT1 |
YOR133W |
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Eft1p|Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; protein coding
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| CAM1 |
TEF3YPL048W |
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Cam1p|Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; protein coding
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| SHE2 |
YKL130C |
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RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud|She2p; protein coding
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| RPL5 |
LPI14RPL1YPL131W |
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Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly|Rpl5p; protein coding
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| HSP104 |
YLL026W |
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Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation|Hsp104p; protein coding
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| SSZ1 |
PDR13YHR064C |
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Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP|Ssz1p; protein coding
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| KSP1 |
YHR082C |
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Ksp1p|Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation; protein coding
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| HRK1 |
YOR267C |
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Hrk1p|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein coding
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| TMA46 |
YOR091W |
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Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p|Tma46p; protein coding
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| PGI1 |
CDC30YBR196C |
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Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation|Pgi1p; protein coding
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| EFT2 |
YDR385W |
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Eft2p|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; protein coding
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| YRA1 |
SHE11YDR381W |
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Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function|Yra1p; protein coding
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| SAP185 |
YJL098W |
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Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p|Sap185p; protein coding
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| RAD50 |
YNL250W |
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Rad50p|Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; protein coding
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| NMD3 |
SRC5YHR170W |
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Nmd3p|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; protein coding
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| ARB1 |
YER036C |
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ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p|Arb1p; protein coding
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| URB1 |
NPA1YKL014C |
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Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit|Urb1p; protein coding
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| RRP1 |
YDR087C |
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Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles|Rrp1p; protein coding
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| LYS4 |
LYS3YDR234W |
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Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway|Lys4p; protein coding
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