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BioGRID | Network Layout for SEC10 for Saccharomyces cerevisiae
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SEC10

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YLR166C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec10p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SEC10

SEC10 was identified with 100 protein interactions and 44 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SEC15
  • YGL233W
    		•  The BioGRID Database Seperator Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles|Sec15p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001)
    hit Guo W (1999)
    Affinity Capture-Western
    bait Guo W (1999)
    hit Wiederkehr A (2004)
    hit De Craene JO (2006)
    Reconstituted Complex
    hit Guo W (1999)
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    bait/hit Gavin AC (2006)
    bait/hit De Craene JO (2006)
    bait Collins SR (2007)
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC8
  • YPR055W
    		•  The BioGRID Database Seperator Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Roth D (1998)
    bait/hit Wiederkehr A (2004)
    hit De Craene JO (2006)
    bait Terbush DR (2001)
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    bait Zhang X (2005)
    bait Gavin AC (2006)
    bait/hit De Craene JO (2006)
    hit Collins SR (2007)
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC5
  • YDR166C
    		•  The BioGRID Database Seperator Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec5p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Roth D (1998)
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    bait/hit Gavin AC (2006)
    bait/hit De Craene JO (2006)
    bait Collins SR (2007)
    Two-hybrid
    hit Guo W (1999)
    Co-fractionation
    bait Guo W (1999)
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC6
  • YIL068C
    		•  The BioGRID Database Seperator Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly|Sec6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    hit Gavin AC (2006)
    bait/hit De Craene JO (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    hit Wiederkehr A (2004)
    hit De Craene JO (2006)
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO84
  • USA3
  • YBR102C
    		•  The BioGRID Database Seperator Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis|Exo84p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait/hit De Craene JO (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait Guo W (1999)
    Two-hybrid
    bait Guo W (1999)
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC3
  • PSL1
  • YER008C
    		•  The BioGRID Database Seperator Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion|Sec3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    bait/hit Gavin AC (2006)
    bait/hit De Craene JO (2006)
    bait Collins SR (2007)
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Growth Defect
    bait Finger FP (1997)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXO70
  • YJL085W
    		•  The BioGRID Database Seperator Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Exo70p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    bait Gavin AC (2006)
    bait/hit De Craene JO (2006)
    Affinity Capture-Western
    bait Dong G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC2
  • YNL272C
    		•  The BioGRID Database Seperator Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport|Sec2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Medkova M (2006)
    Reconstituted Complex
    bait Medkova M (2006)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    bait Nair J (1990)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC1
  • YDR164C
    		•  The BioGRID Database Seperator Sec1p|Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wiederkehr A (2004)
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Lethality
    bait/hit Finger FP (2000)
    Dosage Rescue
    hit Aalto MK (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Bem1p|Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait France YE (2006)
    Reconstituted Complex
    bait France YE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC10
  • YLR166C
    		•  The BioGRID Database Seperator Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit TerBush DR (1996)
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRO7
  • SNI1
  • SOP1
  • YPR032W
    		•  The BioGRID Database Seperator Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor|Sro7p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Zhang X (2005)
    Synthetic Growth Defect
    bait Grosshans BL (2006)
    bait Wadskog I (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC9
  • HSS7
  • YGR009C
    		•  The BioGRID Database Seperator Sec9p|t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Finger FP (2000)
    bait Roth D (1998)
    Dosage Rescue
    hit Elbert M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC4
  • SRO6
  • YFL005W
    		•  The BioGRID Database Seperator Sec4p|Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    bait Roth D (1998)
    Synthetic Lethality
    bait Govindan B (1995)
    bait/hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO2
  • CDC66
  • YOR326W
    		•  The BioGRID Database Seperator Myo2p|One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Govindan B (1995)
    hit Finger FP (2000)
    hit Lillie SH (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1|Sem1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Jantti J (1999)
    Synthetic Rescue
    hit Jantti J (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBH1
  • SEB1
  • YER087C-A
  • YER087C-B
    		•  The BioGRID Database Seperator Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p|Sbh1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Toikkanen JH (2003)
    Phenotypic Enhancement
    hit Toikkanen JH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC42
  • YLR229C
    		•  The BioGRID Database Seperator Cdc42p|Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Adamo JE (2001)
    hit Finger FP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCP1
  • CPR1
  • YHR042W
    		•  The BioGRID Database Seperator NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p|Ncp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GUS1
  • GSN1
  • YGL245W
    		•  The BioGRID Database Seperator Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm|Gus1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DJP1
  • ICS1
  • PAS22
  • YIR004W
    		•  The BioGRID Database Seperator Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ|Djp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MNN5
  • YJL186W
    		•  The BioGRID Database Seperator Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment|Mnn5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDA1
  • YEL042W
    		•  The BioGRID Database Seperator Gda1p|Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC1
  • YGL105W
    		•  The BioGRID Database Seperator Arc1p|Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR139W
  • YBR139W
    		•  The BioGRID Database Seperator Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner|Ybr139wp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCR1
  • YKL150W
    		•  The BioGRID Database Seperator Mcr1p|Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSC1
  • ENS1
  • YJR045C
    		•  The BioGRID Database Seperator Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family|Ssc1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP60
  • CPN60
  • MIF4
  • YLR259C
    		•  The BioGRID Database Seperator Hsp60p|Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]