| Name |
Aliases |
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Description |
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| MON2 |
YSL2YNL297C |
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Mon2p|Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; protein coding
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| RMD7 |
HUR2GET2YER083C |
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Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
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| ALG6 |
YOR002W |
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Alg6p|Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease; protein coding
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| SPT8 |
YLR055C |
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Spt8p|Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters; protein coding
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| MDM20 |
DEC1YOL076W |
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Mdm20p|Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; protein coding
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| SAS2 |
YMR127C |
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Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family|Sas2p; protein coding
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| RUD3 |
GRP1YOR216C |
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Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1|Rud3p; protein coding
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| SPF1 |
COD1PER9PIO1YEL031W |
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P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1|Spf1p; protein coding
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| BRE5 |
YNR051C |
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Bre5p|Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; protein coding
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| SWM1 |
YDR260C |
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Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation|Swm1p; protein coding
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| LTE1 |
MSI2YAL024C |
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Lte1p|Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; protein coding
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| CLA4 |
ERC10YNL298W |
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Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p|Cla4p; protein coding
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| VPH1 |
YOR270C |
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Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes|Vph1p; protein coding
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| GCN5 |
ADA4SWI9YGR252W |
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Gcn5p|Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; protein coding
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| UBP14 |
GID6YBR058C |
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Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T|Ubp14p; protein coding
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| HSP60 |
CPN60MIF4YLR259C |
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Hsp60p|Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; protein coding
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| EFT1 |
YOR133W |
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Eft1p|Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; protein coding
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| MDN1 |
REA1YLR106C |
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Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm|Mdn1p; protein coding
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| PSA1 |
MPG1SRB1VIG9YDL055C |
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GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure|Psa1p; protein coding
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| RNR1 |
CRT7RIR1SDS12YER070W |
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Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits|Rnr1p; protein coding
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| HRD1 |
DER3YOL013C |
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Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
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| TKL1 |
YPR074C |
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Tkl1p|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; protein coding
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| GPM1 |
YKL152C |
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Gpm1p|Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; protein coding
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| RHO1 |
YPR165W |
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GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)|Rho1p; protein coding
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| SUI1 |
MOF2RFR1YNL244C |
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Sui1p|Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; protein coding
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| PRP6 |
RNA6TSM7269YBR055C |
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Prp6p|Splicing factor, component of the U4/U6-U5 snRNP complex; protein coding
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| SNP1 |
YIL061C |
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Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein|Snp1p; protein coding
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| RPS0A |
NAB1YST1YGR214W |
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Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal|Rps0ap; protein coding
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| RPL10 |
GRC5QSR1YLR075W |
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Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family|Rpl10p; protein coding
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| RPN1 |
HRD2NAS1YHR027C |
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Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions|Rpn1p; protein coding
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| CDC19 |
PYK1YAL038W |
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Cdc19p|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; protein coding
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| DBP8 |
YHR169W |
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Dbp8p|Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit; protein coding
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| TUB1 |
YML085C |
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Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules|Tub1p; protein coding
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| SEC27 |
YGL137W |
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Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP|Sec27p; protein coding
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| RPS3 |
SUF14YNL178W |
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Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins|Rps3p; protein coding
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| SSE1 |
LPG3MSI3YPL106C |
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ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
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| YEF3 |
TEF3YLR249W |
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Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP|Yef3p; protein coding
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| TUB3 |
YML124C |
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Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p|Tub3p; protein coding
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| SAM1 |
ETH10YLR180W |
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S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)|Sam1p; protein coding
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| YBR025C |
OLA1 |
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Ola1p|P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide; protein coding
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| TEF1 |
YPR080W |
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Tef1p|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; protein coding
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| SAM2 |
ETH2YDR502C |
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S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differen |
