| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| CHK1 |
YBR274W |
|
Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
|
|
|
|
|
| YGR068C |
YGR068C |
|
Putative protein of unknown function; YGR068C is not an essential gene.
|
|
|
|
|
| PDR11 |
YIL013C |
|
ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth
|
|
|
|
|
| RPL14A |
YKL006W |
|
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth
|
|
|
|
|
| CUE3 |
YGL110C |
|
Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
|
|
|
|
|
| IXR1 |
ORD1YKL032C |
|
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
|
|
|
|
|
| SNF4 |
CAT3SCI1YGL115W |
|
Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
|
|
|
|
|
| GCN20 |
YFR009W |
|
Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
|
|
|
|
|
| PES4 |
YFR023W |
|
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
|
|
|
|
|
| CLG1 |
YGL215W |
|
Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
|
|
|
|
|
| DNM1 |
YLL001W |
|
Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis
|
|
|
|
|
| MSC1 |
YML128C |
|
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
|
|
|
|
|
| COQ10 |
YOL008W |
|
Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
|
|
|
|
|
| TSR3 |
YOR006C |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Null mutant accumulates 20S pre-rRNA
|
|
|
|
|
| MSS18 |
YPR134W |
|
Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
|
|
|
|
|
| RAP1 |
GRF1TUF1TBA1YNL216W |
|
DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
|
|
|
|
|
| BSC6 |
YOL137W |
|
Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
|
|
|
|
|
| BRE5 |
YNR051C |
|
Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
|
|
|
|
|
| CIN4 |
UGX1GTP1YMR138W |
|
GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
|
|
|
|
|
| TPP1 |
YMR156C |
|
DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily
|
|
|
|
|
| YMR166C |
YMR166C |
|
Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
|
|
|
|
|
| IES1 |
YFL013C |
|
Subunit of the INO80 chromatin remodeling complex
|
|
|
|
|
| YDR248C |
YDR248C |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
|
|
|
|
|
| ARP1 |
ACT5YHR129C |
|
Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
|
|
|
|
|
| GSH1 |
YJL101C |
|
Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
|
|
|
|
|
| YAL064C-A |
YAL065C-AYAL064C-A |
|
Putative protein of unknown function; YAL064C-A is not an essential gene
|
|
|
|
|
| SAW1 |
YAL027W |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene
|
|
|
|
|
| BIM1 |
YEB1YER016W |
|
Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
|
|
|
|
|
| TRM1 |
YDR120C |
|
tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
|
|
|
|
|
| MDM10 |
FUN37YAL010C |
|
Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins
|
|
|
|
|
| MUD1 |
YBR119W |
|
U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
|
|
|
|
|
| RPS29B |
YDL061C |
|
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
|
|
|
|
|
| BOI1 |
BOB1GIN7YBL085W |
|
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
|
|
|
|
|
| PEP1 |
VPT1VPS10YBL017C |
|
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
|
|
|
|
|
| PER1 |
COS16YCR044C |
|
Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
|
|
|
|
|
| DTD1 |
YDL219W |
|
D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
|
|
|
|
|
| YDL114W |
YDL114W |
|
Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
|
|
|
|
|
| APA1 |
DTP1YCL050C |
|
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
|
|
|
|
|
| MRC1 |
YCL060CYCL061C |
|
S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
|
|
|
|
|
| YSA1 |
RMA2YBR111C |
|
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity
|
|
|
|
|
| AMN1 |
CST13ICS4YBR158W |
|
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
|
|
|
|
|
| VAC17 |
YCL062WYCL063W |
|
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
|
|
|
|
|
| PEX19 |
PAS12YDL065C |
|
Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
|
|
|
|
|
