| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
 |
| SQT1 |
YIR012W |
 |
Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
|
|
 |
 |
 |
| NMD3 |
SRC5YHR170W |
 |
Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
|
|
 |
 |
 |
| RPL12B |
YDR418W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
|
|
 |
 |
 |
| RPL1A |
SSM1YPL220W |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
|
|
 |
 |
 |
| SAM1 |
ETH10YLR180W |
 |
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
|
|
 |
 |
 |
| RPL2A |
RPL5BYFR031C-A |
 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
|
|
 |
 |
 |
| RPL8A |
MAK7YHL033C |
 |
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
|
|
 |
 |
 |
| KRE33 |
YNL132W |
 |
Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
|
|
 |
 |
 |
| RPL8B |
KRB1SCL41YLL045C |
 |
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
|
|
 |
 |
 |
| MIS1 |
YBR084W |
 |
Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
|
|
 |
 |
 |
| STM1 |
MPT4YLR150W |
 |
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
|
|
 |
 |
 |
| LSG1 |
KRE35YGL099W |
 |
Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
|
|
 |
 |
 |
| SED1 |
YDR077W |
 |
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
|
|
 |
 |
 |
| RPL16A |
RPL13YIL133C |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
|
|
 |
 |
 |
| RPL2B |
LOT2RPL5AYIL018W |
 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
|
|
 |
 |
 |
| RPS30A |
YLR287C-A |
 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
|
|
 |
 |
 |
| RPS4B |
YHR203C |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
|
|
 |
 |
 |
| RPL17B |
YJL177W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
|
|
 |
 |
 |
| RPS22A |
RPS24YJL190C |
 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
|
|
 |
 |
 |
| MRT4 |
YKL009W |
 |
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
|
|
 |
 |
 |
| RPL17A |
RPL17YKL180W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
|
|
 |
 |
 |
| RPL42B |
MAK18YHR141C |
 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
|
|
 |
 |
 |
| RPS5 |
YJR123W |
 |
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
|
|
 |
 |
 |
| RPL15A |
RPL10AYLR029C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
|
|
 |
 |
 |
| RPL14B |
YHL001W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
|
|
 |
 |
 |
| RPL30 |
YGL030W |
 |
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
|
|
 |
 |
 |
| RPL24A |
RPL30AYGL031C |
 |
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
|
|
 |
 |
 |
| RPS24A |
RPS24EAYER074W |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
|
|
 |
 |
 |
| RPL27B |
YDR471W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
|
|
 |
 |
 |
| RPS18A |
YDR450W |
 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
|
|
 |
 |
 |
| RPL7A |
YGL076C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
|
|
 |
 |
 |
| RPL28 |
CYH2YGL103W |
 |
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
|
|
 |
 |
 |
| RIX1 |
IPI2YHR197W |
 |
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
|
|
 |
 |
 |
| RPL11B |
YGR085C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
|
|
 |
 |
 |
| RPL26B |
YGR034W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
|
|
 |
 |
 |
| RPL1B |
SSM2YGL135W |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
|
|
 |
 |
 |
| YMR086W |
YMR086W |
 |
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; cAMP represses YMR086W expression
|
|
 |
 |
 |
| RPS1A |
RP10AYLR441C |
 |
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
|
|
 |
 |
 |
| RPL25 |
YOL127W |
 |
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
|
|
 |
 |
 |
| RPL3 |
MAK8YOR29-14TCM1YOR063W |
 |
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
|
|
 |
 |
 |
| RPL18B |
RP28BYNL301C |
 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
|
|
 |
 |
 |
| RPS3 |
SUF14YNL178W |
 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
|
|
 |
 |
 |
| DBP2 |
YNL112W |
 |
Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
|
|
 |
 |
 |
| NOP15 |
YNL110C |
 |
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
|
|
 |
 |
 |
| RPS7A |
RPS30YOR096W |
 |
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
|
|
 |
 |
 |
| RPL7B |
YPL198W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
|
|
 |
 |
 |
| RPS6A |
YPL090C |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
|
|
 |
 |
 |
| RPL20B |
RPL18A1YOR312C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
|
|
 |
 |
 |
| RPL33B |
YOR234C |
 |
Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
|
|
 |
 |
 |
| RPS7B |
YNL096C |
 |
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
|
|
 |
 |
 |
| RPL16B |
RP23YNL069C |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
|
|
 |
 |
 |
| CCT6 |
TCP6TCP20HTR3YDR188W |
 |
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
|
|
 |
 |
 |
| RPS1B |
PLC2RP10BYML063W |
 |
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
|
|
 |
 |
 |
| RPL6B |
YLR448W |
 |
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
|
|
 |
 |
 |
| RPL36B |
YPL249C-A |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
|
|
 |
 |
 |
| RPL6A |
YL16AYML073C |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
|
|
 |
 |
 |
| RPS17B |
RP51BRPL51BYDR447C |
 |
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
|
|
 |
 |
 |
| UBI4 |
SCD2UB14YLL039C |
 |
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
|
|
 |
 |
 |
| RPL20A |
RPL18A2YMR242C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein
|
|
 |
 |
 |
| RPL36A |
RPL39BYMR194W |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
|
|
 |
 |
 |
| RPL13B |
YMR142C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
|
|
 |
 |
 |
| RPP0 |
RPL10EYLR340W |
 |
Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
|
|
 |
 |
 |
| RPS16B |
YDL083C |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
|
|
 |
 |
 |
| SPC1 |
YJR010C-A |
 |
Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
|
|
 |
 |
 |
| SGV1 |
BUR1YPR161C |
 |
Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p
|
|
 |
 |
 |
| CBR1 |
CBR5YIL043C |
 |
Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
|
|
 |
 |
 |
| PMR1 |
BSD1SSC1LDB1YGL167C |
 |
High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
|
|
 |
 |
 |
| ERP2 |
YAL007C |
 |
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
|
|
 |
 |
 |
| LYS20 |
YDL182W |
 |
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
|
|
 |
 |
 |
| DED81 |
YHR019C |
 |
Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
|
|
 |
 |
 |
| NEW1 |
YPL226W |
 |
ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein
|
|
 |
 |
 |
| LYS12 |
LYS11LYS10YIL094C |
 |
Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
|
|
 |
 |
 |
| ATP3 |
YBR039W |
 |
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
|
|
 |
 |
 |
| TSC10 |
YBR265W |
 |
3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
|
|
 |
 |
 |
| SAS2 |
YMR127C |
 |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
|
|
 |
 |
 |
| NAF1 |
YNL124W |
 |
Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
|
|
 |
 |
 |
| UTP10 |
YJL109C |
 |
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
|
|
 |
 |
 |
| ACS2 |
YLR153C |
 |
Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
|
|
 |
 |
 |
| RAI1 |
YGL246C |
 |
Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
|
|
 |
 |
 |
| CIC1 |
NSA3YHR052W |
 |
Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
|
|
 |
 |
 |
| ENP1 |
MEG1YBR247C |
 |
Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
|
|
 |
 |
 |
| PLB3 |
YOL011W |
 |
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
|
|
 |
 |
 |
| NOG2 |
YNR053C |
 |
Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
|
|
 |
 |
 |
| RPL12A |
YEL054C |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
|
|
 |
 |
 |
| RLI1 |
YDR091C |
 |
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
|
|
 |
 |
 |
| URB1 |
NPA1YKL014C |
 |
Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
|
|
 |
 |
 |
| ESF1 |
YDR365C |
 |
Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
|
|
 |
 |
 |
| RPP2B |
RPL45YPA1YDR382W |
 |
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
|
|
 |
 |
 |
| YOR1 |
YRS1YGR281W |
 |
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
|
|
 |
 |
 |
| RPS14A |
RPL59CRY1YCR031C |
 |
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
|
|
 |
 |
 |
| NOP1 |
LOT3YDL014W |
 |
Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
|
|
 |
 |
 |
| RPS9B |
SUP46RPS13AYBR189W |
 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
|
|
 |
 |
 |
| RPS6B |
RPS102RPS101LPG18YBR181C |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
|
|
 |
 |
 |
| RPS11B |
YBR048W |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
|
|
 |
 |
 |
| RPL31A |
RPL34YDL075W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
|
|
 |
 |
 |
| RPL13A |
YDL082W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
|
|
 |
 |
 |
| RPS13 |
RPS13BRPS13CYDR064W |
 |
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
|
|
 |
 |
 |
| RPS11A |
YDR025W |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
|
|
 |
 |
 |
| RPL35B |
SOS2YDL136W |
 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
|
|
 |
 |
 |
| SSF1 |
YHR066W |
 |
Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
|
|
 |
 |
 |
| RPL18A |
RP28AYOL120C |
 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
|
|
 |
 |
 |
| RPL4A |
YBR031W |
 |
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
|
|
 |
 |
 |
| SCP160 |
YJL080C |
 |
Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
|
|
 |
 |
 |
| RPS8A |
YBL072C |
 |
Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
|
|
 |
 |
 |
| SSZ1 |
PDR13YHR064C |
 |
Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
|
|
 |
 |
 |
| FUN12 |
yIF2YAL035W |
 |
GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
|
|
 |
 |
 |
| GLT1 |
YDL171C |
 |
NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
|
|
 |
 |
 |
| SFB2 |
YNL049C |
 |
Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy
|
|
 |
 |
 |
| SEC31 |
WEB1YDL195W |
 |
Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation
|
|
 |
 |
 |
| RPL19B |
YBL027W |
 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
|
|
 |
 |
 |
| SEC16 |
LPF1YPL085W |
 |
COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
|
|
 |
 |
 |
| HHF1 |
YBR009C |
 |
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
|
|
 |
 |
 |
| PSA1 |
MPG1VIG9SRB1YDL055C |
 |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
|
|
 |
 |
 |
| SEC23 |
YPR181C |
 |
GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p
|
|
 |
 |
 |
| RPL29 |
YFR032C-A |
 |
Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
|
|
 |
 |
 |
| RSA1 |
YPL193W |
 |
Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
|
|
 |
 |
 |
| QCR6 |
COR3UCR6YFR033C |
 |
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
|
|
 |
 |
 |