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BioGRID | Network Layout for RIC1 for Saccharomyces cerevisiae
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RIC1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YLR039C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RIC1

RIC1 was identified with 15 protein interactions and 470 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    bait Siniossoglou S (2000)
    Affinity Capture-Western
    bait Siniossoglou S (2000)
    Dosage Rescue
    hit Bensen ES (2001)
    hit Siniossoglou S (2000)
    Phenotypic Suppression
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGP1
  • YDR137W
    		•  The BioGRID Database Seperator Rgp1p|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Siniossoglou S (2000)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Phenotypic Suppression
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD7
  • HUR2
  • GET2
  • YER083C
    		•  The BioGRID Database Seperator Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPF1
  • COD1
  • PER9
  • PIO1
  • YEL031W
    		•  The BioGRID Database Seperator P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1|Spf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    bait Ando A (2005)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM39
  • GET1
  • YGL020C
    		•  The BioGRID Database Seperator Get1p|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG8
  • DOR1
  • YML071C
    		•  The BioGRID Database Seperator Cog8p|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Lafourcade C (2004)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRT1
  • CDC63
  • DNA26
  • YOR361C
    		•  The BioGRID Database Seperator Prt1p|Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin|Htz1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RUD3
  • GRP1
  • YOR216C
    		•  The BioGRID Database Seperator Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1|Rud3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    bait Gillingham AK (2004)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL1
  • DLP2
  • YBR164C
    		•  The BioGRID Database Seperator Arl1p|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    Dosage Rescue
    hit Bensen ES (2001)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Arp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swr1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GOS1
  • YHL031C
    		•  The BioGRID Database Seperator Gos1p|v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Dosage Rescue
    hit Bensen ES (2001)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps71p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae|Swc3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    hit Krogan NJ (2003)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSG1
  • MUM1
  • TRS85
  • YDR108W
    		•  The BioGRID Database Seperator Gsg1p|Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYS1
  • YJL004C
    		•  The BioGRID Database Seperator Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation|Sys1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Dosage Rescue
    hit Bensen ES (2001)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE5
  • YNR051C
    		•  The BioGRID Database Seperator Bre5p|Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MON2
  • YSL2
  • YNL297C
    		•  The BioGRID Database Seperator Mon2p|Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS1
  • CWH52
  • GGP1
  • YMR307W
    		•  The BioGRID Database Seperator Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor|Gas1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    bait Lesage G (2004)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GYP1
  • YOR29-21
  • YOR070C
    		•  The BioGRID Database Seperator Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion|Gyp1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2004)
    bait Lafourcade C (2004)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE1
  • YDL074C
    		•  The BioGRID Database Seperator Bre1p|E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC28
  • ANU2
  • YIL076W
    		•  The BioGRID Database Seperator Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth|Sec28p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Lge1p|Protein of unknown function; null mutant forms abnormally large cells; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIL039W
  • TED1
    		•  The BioGRID Database Seperator Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)|Ted1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APL6
  • YKS5
  • YGR261C
    		•  The BioGRID Database Seperator Apl6p|Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF4
  • CAT3
  • SCI1
  • YGL115W
    		•  The BioGRID Database Seperator Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis|Snf4p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV14
  • YGL054C
    		•  The BioGRID Database Seperator Erv14p|Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Schuldiner M (2005)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTF1
  • CSL3
  • YGL244W
    		•  The BioGRID Database Seperator Rtf1p|Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GEF1
  • CLC
  • YJR040W
    		•  The BioGRID Database Seperator Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates|Gef1p; protein coding
    Gene Ontology: [View List]