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BioGRID | Network Layout for SSK1 for Saccharomyces cerevisiae
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SSK1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YLR006C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate|Ssk1p; protein coding
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PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
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PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SSK1

SSK1 was identified with 24 protein interactions and 24 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 YPD1
  • YDL235C
    		•  The BioGRID Database Seperator Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus|Ypd1p; protein coding
    Gene Ontology: [View List]
    Co-crystal Structure
    bait Chooback L (2003)
    Reconstituted Complex
    hit Janiak-Spens F (1999)
    bait/hit Janiak-Spens F (2000)
    Two-hybrid
    bait Posas F (1996)
    bait Porter SW (2003)
    bait Porter SW (2005)
    Biochemical Activity
    bait/hit Janiak-Spens F (2005)
    bait/hit Janiak-Spens F (1999)
    PCA
    bait Tarassov K (2008)
    Synthetic Rescue
    bait Posas F (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK2
  • YNR031C
    		•  The BioGRID Database Seperator MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress|Ssk2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    hit Krogan NJ (2006)
    Two-hybrid
    hit Posas F (1998)
    hit Maeda T (1995)
    Biochemical Activity
    bait/hit Posas F (1998)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHO1
  • SSU81
  • YER118C
    		•  The BioGRID Database Seperator Sho1p|Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit O'Rourke SM (1998)
    hit Aguilera J (2005)
    bait Thorsen M (2006)
    Synthetic Growth Defect
    hit Reiser V (2000)
    hit O'Rourke SM (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE11
  • YLR362W
    		•  The BioGRID Database Seperator Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p|Ste11p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Reiser V (2000)
    Synthetic Lethality
    hit O'Rourke SM (2004)
    bait Lee J (2002)
    Synthetic Growth Defect
    hit Sotelo J (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLN1
  • YPD2
  • YIL147C
    		•  The BioGRID Database Seperator Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators|Sln1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Janiak-Spens F (2000)
    Phenotypic Enhancement
    bait Singh KK (2000)
    Synthetic Rescue
    bait Maeda T (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Dosage Lethality
    bait Sato N (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE20
  • YHL007C
    		•  The BioGRID Database Seperator Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases|Ste20p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Reiser V (2000)
    Synthetic Growth Defect
    hit O'Rourke SM (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE50
  • YCL032W
    		•  The BioGRID Database Seperator Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction|Ste50p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit O'Rourke SM (1998)
    Synthetic Lethality
    hit Poplinski A (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LAS21
  • GPI7
  • YJL062W
    		•  The BioGRID Database Seperator Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity|Las21p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Toh-e A (2001)
    Synthetic Rescue
    bait Toh-e A (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEX3
  • SLX5
  • YDL013W
    		•  The BioGRID Database Seperator Slx5p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCK1
  • YPK1
  • YNL307C
    		•  The BioGRID Database Seperator Mck1p|Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST1
  • YLR233C
    		•  The BioGRID Database Seperator Est1p|TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK22
  • YCR073C
    		•  The BioGRID Database Seperator MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p|Ssk22p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome|Clb2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ubersax JA (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • HSL5
  • SRM5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates|Cdc28p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ubersax JA (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition|Rtt109p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Fillingham J (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OPY2
  • YPR075C
    		•  The BioGRID Database Seperator Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone|Opy2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Wu C (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTP2
  • YOR208W
    		•  The BioGRID Database Seperator Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus|Ptp2p; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    bait Sato N (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOG1
  • SSK3
  • YLR113W
    		•  The BioGRID Database Seperator Hog1p|Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit O'Rourke SM (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC42
  • YLR229C
    		•  The BioGRID Database Seperator Cdc42p|Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Reiser V (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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