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BioGRID | Network Layout for SSA2 for Saccharomyces cerevisiae
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SSA2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YG102, YLL024C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall|Ssa2p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 12 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SSA2

SSA2 was identified with 51 protein interactions and 19 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Yam AY (2005)
    Co-fractionation
    bait Yam AY (2005)
    Phenotypic Enhancement
    bait Unno K (1997)
    bait Zhong T (1996)
    bait Jones G (2004)
    Synthetic Growth Defect
    bait Werner-Washburne M (1987)
    bait Baxter BK (1998)
    Synthetic Lethality
    bait Baxter BK (1998)
    bait Baxter BK (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shaner L (2005)
    bait Yam AY (2005)
    Affinity Capture-MS
    bait Yam AY (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP57
  • YGR119C
    		•  The BioGRID Database Seperator Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p|Nup57p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2001)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP100
  • NSP100
  • YKL068W
    		•  The BioGRID Database Seperator Nup100p|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2002)
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP116
  • NSP116
  • YMR047C
    		•  The BioGRID Database Seperator Nup116p|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2001)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Wegele H (2003)
    Affinity Capture-Western
    bait Flom G (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP159
  • NUP158
  • RAT7
  • YIL115C
    		•  The BioGRID Database Seperator Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export|Nup159p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUP35
  • GST1
  • PNM2
  • SAL3
  • YDR172W
    		•  The BioGRID Database Seperator Sup35p|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Bagriantsev SN (2008)
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zhao R (2005)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin|Ubp3p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Kvint K (2008)
    Dosage Rescue
    hit Baxter BK (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT2
  • EXA1
  • SIN1
  • YER161C
    		•  The BioGRID Database Seperator Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins|Spt2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Nelson RJ (1992)
    hit Baxter BK (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA3
  • YG106
  • YBL075C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Ssa3p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Werner-Washburne M (1987)
    Phenotypic Enhancement
    hit Martineau CN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA4
  • YG107
  • YER103W
    		•  The BioGRID Database Seperator Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation|Ssa4p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Werner-Washburne M (1987)
    Phenotypic Enhancement
    hit Martineau CN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NSP1
  • YJL041W
    		•  The BioGRID Database Seperator Essential component of the nuclear pore complex, which mediates nuclear import and export|Nsp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSL1
  • NIK1
  • YKL101W
    		•  The BioGRID Database Seperator Hsl1p|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIC96
  • YFR002W
    		•  The BioGRID Database Seperator Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p|Nic96p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP192
  • YJL039C
    		•  The BioGRID Database Seperator Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205|Nup192p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMK1
  • YFR014C
    		•  The BioGRID Database Seperator Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II|Cmk1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSP5
  • MDP1
  • MUT2
  • NPI1
  • YER125W
    		•  The BioGRID Database Seperator Rsp5p|Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Gupta R (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Seong KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCD6
  • LSM13
  • YPR129W
    		•  The BioGRID Database Seperator Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin|Scd6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Decourty L (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PST2
  • YDR032C
    		•  The BioGRID Database Seperator Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies|Pst2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF6
  • CDC95
  • YPR016C
    		•  The BioGRID Database Seperator Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits|Tif6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Graindorge JS (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP1
  • MGO1
  • YDR328C
    		•  The BioGRID Database Seperator Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase|Skp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Tagwerker C (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Johnson JL (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • AGS3
  • TUP7
  • VAC5
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance|Pho80p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLH1
  • PMS2
  • YMR167W
    		•  The BioGRID Database Seperator Mlh1p|Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI3
  • YNL197C
    		•  The BioGRID Database Seperator RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start|Whi3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang H (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP49
  • NSP49
  • YGL172W
    		•  The BioGRID Database Seperator Nup49p|Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Allen NP (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR052C
  • RFS1
    		•  The BioGRID Database Seperator Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern|Rfs1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCP1
  • YOL149W
    		•  The BioGRID Database Seperator Dcp1p|Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zhang S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC3
  • YDR303C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p|Rsc3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baetz KK (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL6
  • RSC7
  • YMR091C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length|Npl6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baetz KK (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NSL1
  • YPL233W
    		•  The BioGRID Database Seperator Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation|Nsl1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nekrasov VS (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC2
  • YLR357W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance|Rsc2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baetz KK (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRA1
  • SHE11
  • YDR381W
    		•  The BioGRID Database Seperator Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function|Yra1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Kashyap AK (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle|Pre1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Verma R (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome|Clb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Honey S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMS1
  • YNL082W
    		•  The BioGRID Database Seperator ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL|Pms1p; protein coding