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BioGRID | Network Layout for UBI4 for Saccharomyces cerevisiae
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UBI4

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SCD2, UB14, YLL039C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with UBI4

UBI4 was identified with 77 protein interactions and 34 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator Doa1p|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Lis ET (2006)
    Reconstituted Complex
    bait Lis ET (2006)
    bait Rumpf S (2006)
    hit Ren J (2008)
    Synthetic Lethality
    bait Lis ET (2006)
    Phenotypic Enhancement
    hit Collins SR (2007)
    Dosage Rescue
    bait Brandina I (2007)
    bait Ren J (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS9
  • VPL31
  • VPT9
  • YML097C
    		•  The BioGRID Database Seperator A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin|Vps9p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Davies BA (2003)
    bait Shih SC (2003)
    bait Kang RS (2003)
    Two-hybrid
    hit Shih SC (2003)
    hit Donaldson KM (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bertolaet BL (2001)
    Two-hybrid
    bait Bertolaet BL (2001)
    Reconstituted Complex
    hit Hobeika M (2007)
    Co-crystal Structure
    bait Haririnia A (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD2
  • YDL190C
    		•  The BioGRID Database Seperator Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3|Ufd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Two-hybrid
    hit Rao H (2002)
    Affinity Capture-Western
    hit Koegl M (1999)
    Biochemical Activity
    bait/hit Tu D (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS27
  • DID7
  • GRD11
  • SSV17
  • YNR006W
    		•  The BioGRID Database Seperator Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)|Vps27p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bilodeau PS (2002)
    Protein-peptide
    bait/hit Swanson KA (2003)
    Co-crystal Structure
    hit Swanson KA (2003)
    Phenotypic Suppression
    hit Ren J (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSK2
  • YMR276W
    		•  The BioGRID Database Seperator Dsk2p|Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Rao H (2002)
    Co-crystal Structure
    bait Ohno A (2005)
    Reconstituted Complex
    bait Ohno A (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DDI1
  • VSM1
  • YER143W
    		•  The BioGRID Database Seperator DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control|Ddi1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bertolaet BL (2001)
    Two-hybrid
    bait Bertolaet BL (2001)
    hit Rao H (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GGA2
  • YHR108W
    		•  The BioGRID Database Seperator Gga2p|Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Scott PM (2004)
    Two-hybrid
    hit Scott PM (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • CCR1
  • GLC2
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis|Snf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    bait Elbing K (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUE2
  • YKL090W
    		•  The BioGRID Database Seperator Cue2p|Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Kang RS (2003)
    Co-crystal Structure
    bait Kang RS (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC48
  • YDL126C
    		•  The BioGRID Database Seperator ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome|Cdc48p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Rape M (2001)
    Two-hybrid
    bait/hit Decottignies A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Pol30p|Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Haracska L (2006)
    bait Zhuang Z (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSP5
  • MDP1
  • MUT2
  • NPI1
  • YER125W
    		•  The BioGRID Database Seperator Rsp5p|Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Harkness TA (2002)
    bait Kabir MA (2005)
    bait Estrella LA (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA4
  • DOS1
  • MUT4
  • NPI2
  • YDR069C
    		•  The BioGRID Database Seperator Doa4p|Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Fiorani P (2004)
    bait Swaminathan S (1999)
    Phenotypic Suppression
    bait Singer JD (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC5
  • RMC1
  • YOR249C
    		•  The BioGRID Database Seperator Apc5p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Harkness TA (2002)
    Phenotypic Suppression
    bait Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    hit Abolmaali S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPC31
  • ACP2
  • RPC8
  • YNL151C
    		•  The BioGRID Database Seperator RNA polymerase III subunit C31; contains HMG-like C-terminal domain|Rpc31p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Briand JF (2001)
    bait Thuillier V (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHS5
  • CAL3
  • YLR330W
    		•  The BioGRID Database Seperator Chs5p|Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lesage G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHS3
  • CAL1
  • CSD2
  • DIT101
  • YBR023C
    		•  The BioGRID Database Seperator Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan|Chs3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lesage G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEX67
  • YPL169C
    		•  The BioGRID Database Seperator Mex67p|Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Hobeika M (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EDE1
  • BUD15
  • YBL047C
    		•  The BioGRID Database Seperator Ede1p|Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; protein coding
    Gene Ontology: [View List]
    Co-crystal Structure
    bait Swanson KA (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD1
  • LPB9
  • YPL022W
    		•  The BioGRID Database Seperator Rad1p|Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Seong KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains|Sla1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait He Y (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP8
  • DBF3
  • DNA39
  • RNA8
  • YHR165C
    		•  The BioGRID Database Seperator Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa|Prp8p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Bellare P (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN4
  • AAS3
  • ARG9
  • YEL009C
    		•  The BioGRID Database Seperator Gcn4p|Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Seong KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1|Sic1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Haririnia A (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL4
  • GAL81
  • YPL248C
    		•  The BioGRID Database Seperator DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p|Gal4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Archer CT (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN8
  • KSL2
  • SDS15
  • YEL061C
    		•  The BioGRID Database Seperator Cin8p|Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Crasta K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT1
  • ARN3
  • YEL065W
    		•  The BioGRID Database Seperator Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p|Sit1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Erpapazoglou Z (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • YOR368W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins|Rad17p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Fu Y (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23A
  • HHR23A
  • MGC111083
  • EG5886
    		•  The BioGRID Database Seperator RAD23, yeast homolog, A|UV excision repair protein RAD23 homolog A; RAD23 homolog A (S. cerevisiae)
    Gene Ontology: [View List]
    Co-crystal Structure
    bait Haririnia A (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait/hit Tu D (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YUH1
  • YJR099W
    		•  The BioGRID Database Seperator Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p|Yuh1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Sakamoto T (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC4
  • YBR082C
    		•  The BioGRID Database Seperator Ubc4p|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait/hit Tu D (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIB1
  • YDR313C
    		•  The BioGRID Database Seperator Pib1p|RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain; protein coding