The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for RSC8 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

RSC8

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SWH3, YFR037C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters|Rsc8p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 11 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RSC8

RSC8 was identified with 128 protein interactions and 78 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 STH1
  • NPS1
  • YIL126W
    		•  The BioGRID Database Seperator ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p|Sth1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    hit Treich I (1997)
    hit Wilson B (2006)
    Two-hybrid
    bait Hsu JM (2003)
    Co-purification
    bait Kasten M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC6
  • YCR052W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p|Rsc6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Baetz KK (2004)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    bait/hit Treich I (1998)
    Reconstituted Complex
    hit Treich I (1998)
    Dosage Rescue
    hit Treich I (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC2
  • YLR357W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance|Rsc2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    bait Saha A (2002)
    bait Ferreira H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL6
  • RSC7
  • YMR091C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length|Npl6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Uetz P (2000)
    Dosage Rescue
    hit Wilson B (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC9
  • YML127W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway|Rsc9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Baetz KK (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    Synthetic Lethality
    bait Damelin M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT102
  • YGR275W
    		•  The BioGRID Database Seperator Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition|Rtt102p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Baetz KK (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Graumann J (2004)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC3
  • YDR303C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p|Rsc3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Baetz KK (2004)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    hit Wilson B (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTL1
  • YCR020W-B
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance|Htl1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Baetz KK (2004)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Two-hybrid
    hit Lu YM (2003)
    Reconstituted Complex
    hit Florio C (2007)
    Dosage Rescue
    hit Romeo MJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFH1
  • YLR321C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progressionand maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog|Sfh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP7
  • SWP61
  • RSC11
  • YPR034W
    		•  The BioGRID Database Seperator Arp7p|Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP9
  • SWP59
  • RSC12
  • YMR033W
    		•  The BioGRID Database Seperator Arp9p|Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC58
  • YLR033W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit|Rsc58p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC4
  • YKR008W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling|Rsc4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Baetz KK (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC1
  • YGR056W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook|Rsc1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ISW1
  • SGN2
  • YBR245C
    		•  The BioGRID Database Seperator Isw1p|Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC30
  • YHR056C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive|Rsc30p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Baetz KK (2004)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • GAM2
  • RPD1
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity|Sin3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO31
  • RPC1
  • RPC160
  • YOR116C
    		•  The BioGRID Database Seperator RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit|Rpo31p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABF2
  • YMR072W
    		•  The BioGRID Database Seperator Abf2p|Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP95
  • RSL1
  • YLR347C
    		•  The BioGRID Database Seperator Kap95p|Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC8
  • SWH3
  • YFR037C
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters|Rsc8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    Two-hybrid
    bait/hit Treich I (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPC34
  • YNR003C
    		•  The BioGRID Database Seperator RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex|Rpc34p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP10
  • HMO2
  • YDL002C
    		•  The BioGRID Database Seperator Nhp10p|Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • BUR3
  • LPF4
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity|Mot1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RET1
  • PDS2
  • RPC128
  • RPC2
  • YOR207C
    		•  The BioGRID Database Seperator Ret1p|Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IOC3
  • YFR013W
    		•  The BioGRID Database Seperator Ioc3p|Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • BUR5
  • SIN2
  • YBR010W
    		•  The BioGRID Database Seperator Hht1p|One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA2
  • BUF1
  • RPA2
  • YNL312W
    		•  The BioGRID Database Seperator Rfa2p|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ISW2
  • YOR304W
    		•  The BioGRID Database Seperator Isw2p|Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator Hhf1p|One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • SPO15
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis|Vps1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRM1
  • MTR1
  • PRP20
  • YGL097W
    		•  The BioGRID Database Seperator Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p|Srm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Dilworth DJ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator Hhf2p|One of two identical histone H4 proteins (see also HHF1); core histone required for chroma