The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for HAC1 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

HAC1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: ERN4, IRE15, YFL031W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Hac1p|bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with HAC1

HAC1 was identified with 8 protein interactions and 73 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 DIE2
  • ALG10
  • YGR227W
    		•  The BioGRID Database Seperator Die2p|Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Uchimura S (2005)
    Synthetic Lethality
    hit Uchimura S (2005)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Protein-RNA
    bait Niwa M (2005)
    Synthetic Rescue
    bait Nikawa J (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ITC1
  • YGL133W
    		•  The BioGRID Database Seperator Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1|Itc1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Sugiyama M (2001)
    Synthetic Rescue
    hit Sugiyama M (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Friedlander R (2000)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOS2
  • RTL1
  • YGL194C
    		•  The BioGRID Database Seperator Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity|Hos2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Cohen TJ (2008)
    Synthetic Lethality
    bait Cohen TJ (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPF1
  • COD1
  • PER9
  • PIO1
  • YEL031W
    		•  The BioGRID Database Seperator P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1|Spf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Cronin SR (2002)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN5
  • ADA4
  • SWI9
  • YGR252W
    		•  The BioGRID Database Seperator Gcn5p|Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Welihinda AA (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • MOF6
  • REC3
  • SDI2
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing|Rpd3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Schroder M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p|Yck1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • GAM2
  • RPD1
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity|Sin3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Schroder M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAC1
  • ERN4
  • IRE15
  • YFL031W
    		•  The BioGRID Database Seperator Hac1p|bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Nikawa J (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KSP1
  • YHR082C
    		•  The BioGRID Database Seperator Ksp1p|Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC4
  • YFL009W
    		•  The BioGRID Database Seperator Cdc4p|F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Pal B (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC66
  • HSS1
  • SEC71
  • YBR171W
    		•  The BioGRID Database Seperator Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER|Sec66p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIL1
  • SLS1
  • YOL031C
    		•  The BioGRID Database Seperator Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein|Sil1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD3
  • YLR207W
    		•  The BioGRID Database Seperator Hrd3p|Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEL1
  • UBX2
  • YML013W
    		•  The BioGRID Database Seperator Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain|Ubx2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OPI3
  • PEM2
  • YJR073C
    		•  The BioGRID Database Seperator Opi3p|Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ICE2
  • YIL090W
    		•  The BioGRID Database Seperator Ice2p|Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO88
  • YBR106W
    		•  The BioGRID Database Seperator Pho88p|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST3
  • YOR085W
    		•  The BioGRID Database Seperator Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins|Ost3p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LHS1
  • CER1
  • SSI1
  • YKL073W
    		•  The BioGRID Database Seperator Lhs1p|Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LAS21
  • GPI7
  • YJL062W
    		•  The BioGRID Database Seperator Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity|Las21p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC2
  • SPY1
  • YML055W
    		•  The BioGRID Database Seperator Spc2p|Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCJ1
  • YMR214W
    		•  The BioGRID Database Seperator One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins|Scj1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE24
  • AFC1
  • PIO2
  • YJR117W
    		•  The BioGRID Database Seperator Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans|Ste24p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEY1
  • YOR165W
    		•  The BioGRID Database Seperator Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective)|Sey1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR357C
  • YDR357C
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern|Ydr357cp; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCT1
  • BSR2
  • CCT1
  • YGR202C
    		•  The BioGRID Database Seperator Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding|Pct1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCR061W
  • YCR062W
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern|Ycr061wp; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MON2
  • YSL2
  • YNL297C
    		•  The BioGRID Database Seperator Mon2p|Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC24
  • ANU1
  • YIL109C
    		•  The BioGRID Database Seperator Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p|Sec24p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Higashio H (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL300W
  • YNL300W
    		•  The BioGRID Database Seperator Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid|Ynl300wp; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TLG2
  • YOL018C
    		•  The BioGRID Database Seperator Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation|Tlg2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCS3
  • YGL126W
    		•  The BioGRID Database Seperator Protein required for inositol prototrophy, appears to be involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis|Scs3p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC22
  • SLY2
  • TSL26
  • YLR268W
    		•  The BioGRID Database Seperator R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog|Sec22p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TVP15
  • YDR100W
    		•  The BioGRID Database Seperator Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p|Tvp15p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSC7
  • YHR039C
    		•  The BioGRID Database Seperator Msc7p|Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHK1
  • ALG3
  • YBL082C
    		•  The BioGRID Database Seperator Alg3p|Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KRE27
  • YIL027C
    		•  The BioGRID Database Seperator Kre27p|Protein of unknown function; null mutant shows K1 killer toxin resistance; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RER1
  • YCL001W
    		•  The BioGRID Database Seperator Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER|Rer1p; protein coding
    Gene Ontology: [View List]