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BioGRID | Network Layout for OTU1 for Saccharomyces cerevisiae
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OTU1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YFL044C
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PIXEL
The BioGRID Database Seperator
Description: Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family|Otu1p; protein coding
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PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
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PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
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PIXEL
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Download interactions associated with OTU1

OTU1 was identified with 15 protein interactions and 2 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 CDC48
  • YDL126C
    		•  The BioGRID Database Seperator ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome|Cdc48p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Reconstituted Complex
    hit Rumpf S (2006)
    Affinity Capture-Western
    hit Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator Doa1p|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Rumpf S (2006)
    Affinity Capture-Western
    hit Rumpf S (2006)
    Dosage Rescue
    bait Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD2
  • YDL190C
    		•  The BioGRID Database Seperator Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3|Ufd2p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Rumpf S (2006)
    Affinity Capture-Western
    hit Rumpf S (2006)
    Synthetic Rescue
    bait Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHP1
  • UBX1
  • YBL058W
    		•  The BioGRID Database Seperator Shp1p|UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Rumpf S (2006)
    Affinity Capture-Western
    hit Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL4
  • HRD4
  • YBR170C
    		•  The BioGRID Database Seperator Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation|Npl4p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Rumpf S (2006)
    Affinity Capture-Western
    hit Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Rumpf S (2006)
    Affinity Capture-Western
    hit Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT23
  • YKL020C
    		•  The BioGRID Database Seperator ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting|Spt23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDR5
  • LEM1
  • STS1
  • YDR1
  • YOR153W
    		•  The BioGRID Database Seperator Pdr5p|Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Subba Rao G (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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