| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
 |
| CDC1 |
ESP2DSC1DSR1YDR182W |
 |
Putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution
|
|
 |
 |
 |
| GET2 |
RMD7HUR2YER083C |
 |
Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
|
|
 |
 |
 |
| GAS1 |
GGP1CWH52YMR307W |
 |
Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
|
|
 |
 |
 |
| ALG5 |
YPL227C |
 |
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
|
|
 |
 |
 |
| OST3 |
YOR085W |
 |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
|
|
 |
 |
 |
| ERV14 |
YGL054C |
 |
Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
|
|
 |
 |
 |
| PMR1 |
BSD1SSC1LDB1YGL167C |
 |
High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
|
|
 |
 |
 |
| PKC1 |
HPO2STT1CLY15YBL105C |
 |
Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
|
|
 |
 |
 |
| SEC27 |
YGL137W |
 |
Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
|
|
 |
 |
 |
| SEC28 |
ANU2YIL076W |
 |
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
|
|
 |
 |
 |
| RGP1 |
YDR137W |
 |
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
|
|
 |
 |
 |
| GET1 |
MDM39YGL020C |
 |
Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
|
|
 |
 |
 |
| CWH41 |
GLS1DER7YGL027C |
 |
Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
|
|
 |
 |
 |
| RIC1 |
YLR039C |
 |
Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
|
|
 |
 |
 |
| ARL1 |
DLP2YBR164C |
 |
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
|
|
 |
 |
 |
| GPI8 |
YDR331W |
 |
ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
|
|
 |
 |
 |
| YHR140W |
YHR140W |
 |
Putative integral membrane protein of unknown function
|
|
 |
 |
 |
| PRP4 |
RNA4YPR178W |
 |
Splicing factor, component of the U4/U6-U5 snRNP complex
|
|
 |
 |
 |
| YFL040W |
YFL040W |
 |
Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
|
|
 |
 |
 |
| SUT2 |
YPR009W |
 |
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
|
|
 |
 |
 |
| BEM2 |
IPL2SUP9TSL1YER155C |
 |
Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
|
|
 |
 |
 |
| HAC1 |
ERN4IRE15YFL031W |
 |
bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
|
|
 |
 |
 |
| KRE5 |
YOR336W |
 |
Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
|
|
 |
 |
 |
| NIC96 |
YFR002W |
 |
Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
|
|
 |
 |
 |
| BUD27 |
URI1YFL023W |
 |
Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
|
|
 |
 |
 |
| GYP8 |
YFL027C |
 |
GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
|
|
 |
 |
 |
| ANP1 |
MNN8GEM3YEL036C |
 |
Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
|
|
 |
 |
 |
| RIM15 |
TAK1YFL033C |
 |
Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
|
|
 |
 |
 |
| VMA8 |
YEL051W |
 |
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
|
|
 |
 |
 |
| PTC1 |
CWH47KCS2TPD1YDL006W |
 |
Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
|
|
 |
 |
 |
| RPT2 |
YTA5YHS4YDL007W |
 |
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
|
|
 |
 |
 |
| PPH21 |
PPH1YDL134C |
 |
Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
|
|
 |
 |
 |
| TFP1 |
VMA1CLS8YDL185W |
 |
Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
|
|
 |
 |
 |
| GSG1 |
MUM1TRS85YDR108W |
 |
Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
|
|
 |
 |
 |
| NBP2 |
YDR162C |
 |
Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
|
|
 |
 |
 |
| YPI1 |
YFR003C |
 |
Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen
|
|
 |
 |
 |
| EMI1 |
YDR512C |
 |
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation
|
|
 |
 |
 |
| SRP101 |
YDR292C |
 |
Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
|
|
 |
 |
 |
| RML2 |
YEL050C |
 |
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
|
|
 |
 |
 |
| RNA15 |
YGL044C |
 |
Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p
|
|
 |
 |
 |
| YHC1 |
YLR298C |
 |
Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
|
|
 |
 |
 |
| EXG1 |
BGL1YLR300W |
 |
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
|
|
 |
 |
 |
| YLR152C |
YLR152C |
 |
Putative protein of unknown function; YLR152C is not an essential gene
|
|
 |
 |
 |
| CSF1 |
YLR087C |
 |
Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
 |
 |
 |
| BOS1 |
SEC32YLR078C |
 |
v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
|
|
 |
 |
 |
| CDC3 |
YLR314C |
 |
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
|
|
 |
 |
 |
| ORM2 |
YLR350W |
 |
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
|
|
 |
 |
 |
| ERG6 |
VID1SED6ISE1YML008C |
 |
Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane
|
|
 |
 |
 |
| TAF8 |
TAF65YML114C |
 |
TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
|
|
 |
 |
 |
| GAB1 |
CDC91YLR459W |
 |
GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
|
|
 |
 |
 |
| DYN3 |
YMR299C |
 |
Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
|
|
 |
 |
 |
| RIA1 |
EFL1YNL163C |
 |
Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)
|
|
 |
 |
 |
| ELM1 |
LDB9YKL048C |
 |
Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
|
|
 |
 |
 |
| SMI1 |
KNR4YGR229C |
 |
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
|
|
 |
 |
 |
| SLT2 |
BYC2MPK1SLK2YHR030C |
 |
Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
|
|
 |
 |
 |
| CLC1 |
SCD4YGR167W |
 |
Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
|
|
 |
 |
 |
| VPS27 |
GRD11VPL23VPT27YNR006W |
 |
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
|
|
 |
 |
 |
| ERV41 |
YML067C |
 |
Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
|
|
 |
 |
 |
| MNN11 |
YJL183W |
 |
Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
|
|
 |
 |
 |
| VMA9 |
LDB10CWH36YCL005W-A |
 |
Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis
|
|
 |
 |
 |
| HOC1 |
YJR075W |
 |
Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
|
|
 |
 |
 |
| SSC1 |
ENS1YJR045C |
 |
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
|
|
 |
 |
 |
| BCK1 |
LAS3SSP31SAP3YJL095W |
 |
Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
|
|
 |
 |
 |
| SWI3 |
TYE2YJL176C |
 |
Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
|
|
 |
 |
 |
| DUO1 |
YGL061C |
 |
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
|
|
 |
 |
 |
| PRY3 |
YJL078C |
 |
Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins
|
|
 |
 |
 |
| ERP2 |
YAL007C |
 |
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
|
|
 |
 |
 |
| ERV46 |
FUN9YAL042W |
 |
Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
|
|
 |
 |
 |
| ERG4 |
YGL012W |
 |
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
|
|
 |
 |
 |
| CNE1 |
FUN48YAL058W |
 |
Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
|
|
 |
 |
 |
| CHS7 |
YHR142W |
 |
Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
|
|
 |
 |
 |
| GUP1 |
YGL084C |
 |
Plasma membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases
|
|
 |
 |
 |
| GYP1 |
YOR29-21YOR070C |
 |
Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
|
|
 |
 |
 |
| MGA2 |
YIR033W |
 |
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
|
|
 |
 |
 |
| LPP1 |
YDR503C |
 |
Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
|
|
 |
 |
 |
| LAS21 |
GPI7YJL062W |
 |
Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
|
|
 |
 |
 |
| IRE1 |
ERN1YHR079C |
 |
Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
|
|
 |
 |
 |
| BSD2 |
YBR290W |
 |
Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
|
|
 |
 |
 |
| ALG6 |
YOR002W |
 |
Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
|
|
 |
 |
 |
| GIM4 |
PFD2YEL003W |
 |
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
|
|
 |
 |
 |
| GIM3 |
PFD4YNL153C |
 |
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
|
|
 |
 |
 |
| PAC10 |
RKS2PFD3GIM2YGR078C |
 |
Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
|
|
 |
 |
 |
| YPT6 |
YLR262C |
 |
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
|
|
 |
 |
 |
| KRE11 |
TRS65YGR166W |
 |
Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport
|
|
 |
 |
 |
| KRE1 |
YNL322C |
 |
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
|
|
 |
 |
 |
| AGP1 |
YCC5YCL025C |
 |
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
|
|
 |
 |
 |
| HSP82 |
HSP90YPL240C |
 |
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
|
|
 |
 |
 |
| SWF1 |
PSL10YDR126W |
 |
Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
|
|
 |
 |
 |
| ALG8 |
YOR29-18YOR067C |
 |
Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
|
|
 |
 |
 |
| MON2 |
YSL2YNL297C |
 |
Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
|
|
 |
 |
 |
| NNF2 |
YGR089W |
 |
Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
|
|
 |
 |
 |
| PIL1 |
YGR086C |
 |
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
|
|
 |
 |
 |
| PHO90 |
YJL198W |
 |
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
|
|
 |
 |
 |
| PGA3 |
YML125C |
 |
Essential protein required for maturation of Gas1p and Pho8p, protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
|
|
 |
 |
 |
| PKR1 |
YMR123W |
 |
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
|
|
 |
 |
 |
| SCS7 |
FAH1YMR272C |
 |
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
|
|
 |
 |
 |
| SMF1 |
SBS1YOL122C |
 |
Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
|
|
 |
 |
 |
| DEP1 |
FUN54YAL013W |
 |
Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
|
|
 |
 |
 |
| SEC14 |
PIT1YMR079W |
 |
Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs
|
|
 |
 |
 |
| RPD3 |
SDI2MOF6REC3YNL330C |
 |
Histone deacetylase; regulates transcription and silencing
|
|
 |
 |
 |
| ELP3 |
TOT3HPA1YPL086C |
 |
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
|
|
 |
 |
 |
| YET1 |
YKL065C |
 |
Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
|
|
 |
 |
 |
| SEC66 |
HSS1SEC71YBR171W |
 |
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
|
|
 |
 |
 |
| ROT2 |
GLS2YBR229C |
 |
Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
|
|
 |
 |
 |
| PMT2 |
FUN25YAL023C |
 |
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
|
|
 |
 |
 |
| SWA2 |
AUX1BUD24YDR320C |
 |
Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
|
|
 |
 |
 |
| OPI3 |
PEM2YJR073C |
 |
Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
|
|
 |
 |
 |
| PMT1 |
YDL095W |
 |
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals
|
|
 |
 |
 |
| TRS20 |
YBR254C |
 |
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
|
|
 |
 |
 |
| SPF1 |
COD1PER9PIO1YEL031W |
 |
P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
|
|
 |
 |
 |
| TLG2 |
YOL018C |
 |
Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
|
|
 |
 |
 |
| STE24 |
AFC1PIO2YJR117W |
 |
Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
|
|
 |
 |
 |
| YJL171C |
YJL171C |
 |
GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
|
|
 |
 |
 |
| BNA4 |
YBL098W |
 |
Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
|
|
 |
 |
 |