| Name |
Aliases |
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Description |
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| HMRA1 |
YCR097WBYCR097W |
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Hmra1p|Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells; protein coding
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| MCM1 |
FUN80YMR043W |
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Mcm1p|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; protein coding
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| TUP1 |
AAR1AER2AMM1YCR084C |
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General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes|Tup1p; protein coding
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| MATALPHA2 |
ALPHA2YCR039C |
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Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette|Matalpha2p; protein coding
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| CTF8 |
YHR191C |
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Ctf8p|Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; protein coding
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| KAR3 |
OSR11YPR141C |
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Kar3p|Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate; protein coding
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| EST1 |
YLR233C |
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Est1p|TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere; protein coding
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| NAT3 |
YPR131C |
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Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met|Nat3p; protein coding
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| HPR5 |
SRS2YJL092W |
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DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination|Srs2p; protein coding
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| CHL1 |
CTF1LPA9YPL008W |
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Chl1p|Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p; protein coding
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| EST3 |
YIL009C-A |
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Component of the telomerase holoenzyme, involved in telomere replication|Est3p; protein coding
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| EST2 |
YLR318W |
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Est2p|Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia; protein coding
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| UMP1 |
RNS2YBR173C |
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Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly|Ump1p; protein coding
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| QRI8 |
UBC7YMR022W |
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Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
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| STE12 |
YHR084W |
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Ste12p|Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; protein coding
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| RAD6 |
UBC2YGL058W |
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Rad6p|Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p); protein coding
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| CUE1 |
KIS4YMR264W |
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Cue1p|Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; protein coding
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| SSM4 |
DOA10KIS3YIL030C |
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Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
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| BUB1 |
YGR188C |
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Bub1p|Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p; protein coding
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| RPN4 |
SON1UFD5YDL020C |
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Rpn4p|Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; protein coding
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| BUB3 |
YOR026W |
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Bub3p|Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; protein coding
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