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APS
Homo sapiens
Aliases:
SH2B2, EG10603
Description:
adaptor protein with pleckstrin homology and src homology 2 domains; SH2B adaptor protein 2
Links:
[Entrez-Gene]
[OMIM]
[HPRD]
[HGNC]
[Ensembl]
Gene Ontology:
6 total GO mappings for this record.
[view list]
Function
Process
Component
•
SH3/SH2 adaptor activity
(
IDA
)
•
JAK pathway signal transd ...
(
IDA
)
•
antimicrobial humoral res ...
(
NR
)
•
intracellular signaling c ...
(
IDA
)
•
cytoplasm
(
IDA
)
•
plasma membrane
(
IDA
)
Download interactions associated with APS
APS was identified with
5
protein interactions
Name
Aliases
Description
Evidence Code(s)
Role
Source(s)
NTRK1
MTC
TRK
TRK1
EG4914
Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A; neurotrophic tyrosine kinase, receptor, type 1
Gene Ontology:
[View List]
Two-hybrid
bait
Qian X (1998)
Affinity Capture-Western
hit
Qian X (1998)
GRB2
ASH
EGFRBP-GRB2
Grb3-3
EG2885
HT027|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3; growth factor receptor-bound protein 2
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Qian X (1998)
CBL
C-CBL
CBL2
RNF55
EG867
Cas-Br-M (murine) ecotropic retroviral transforming sequence; oncogene CBL2
Gene Ontology:
[View List]
Reconstituted Complex
hit
Wakioka T (1999)
JAK2
EG3717
Janus kinase 2|OTTHUMP00000043260|tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase)
Gene Ontology:
[View List]
Biochemical Activity
bait
Wakioka T (1999)
Copyright © 2009,
Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.