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CXCR4
Homo sapiens
Aliases:
D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, CD184, EG7852
Description:
C-X-C chemokine receptor type 4|CD184 antigen|chemokine (C-X-C motif), receptor 4 (fusin)|chemokine receptor 4|fusin|leukocyte-derived seven-transmembrane-domain receptor|lipopolysaccharide-associated protein 3|neuropeptide Y receptor Y3|seven transmembrane helix receptor|seven-transmembrane-segment receptor, spleen|stromal cell-derived factor 1 receptor; chemokine (C-X-C motif) receptor 4
Links:
[Entrez-Gene]
[OMIM]
[HGNC]
[HPRD]
[Ensembl]
Gene Ontology:
18 total GO mappings for this record.
[view list]
Function
Process
Component
•
actin binding
(
IDA
)
•
protein binding
(
IPI
)
•
myosin light chain bindin ...
(
IDA
)
•
C-X-C chemokine receptor ...
(
NAS
)
•
coreceptor activity
(
TAS
)
•
apoptosis
(
TAS
)
•
G-protein coupled recepto ...
(
TAS
)
•
chemotaxis
(
TAS
)
•
activation of MAPK activi ...
(
TAS
)
•
elevation of cytosolic ca ...
(
TAS
)
•
response to virus
(
TAS
)
•
response to hypoxia
(
IEP
)
•
immune response
(
TAS
)
•
inflammatory response
(
TAS
)
•
cytoplasm
(
TAS
)
•
integral to plasma membra ...
(
TAS
)
•
plasma membrane
(
TAS
)
•
leading edge
(
IDA
)
Download interactions associated with CXCR4
CXCR4 was identified with
9
protein interactions
Name
Aliases
Description
Evidence Code(s)
Role
Source(s)
PTK2
FADK
FAK
FAK1
EG5747
PTK2 protein tyrosine kinase 2; focal adhesion kinase 1
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Wang J (2001)
SOCS3
CIS3
Cish3
MGC71791
EG9021
STAT induced STAT inhibitor 3|cytokine-induced SH2 protein 3; suppressor of cytokine signaling 3
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Soriano SF (2002)
CD4
CD4mut
EG920
CD4 antigen|CD4 antigen (p55)|CD4 receptor; CD4 molecule
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Xiao X (2000)
ADRBK2
BARK2
GRK3
EG157
adrenergic, beta, receptor kinase 2; beta adrenergic receptor kinase 2
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Wang J (2001)
PTPN6
HCP
HCPH
HPTP1C
EG5777
70 kda SHP-1L protein|hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C; protein tyrosine phosphatase, non-receptor type 6
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Vila-Coro AJ (1999)
CCR5
CC-CKR-5
CCCKR5
CD195
EG1234
C-C chemokine receptor 5|C-C chemokine receptor type 5|CCR5 chemokine receptor|chemokine (C-C) receptor 5|chemokine receptor CCR5|chemr13; chemokine (C-C motif) receptor 5
Gene Ontology:
[View List]
Reconstituted Complex
hit
Agrawal L (2002)
JAK3
JAK-3
JAK3_HUMAN
JAKL
EG3718
Janus kinase 3|leukocyte Janus kinase|tyrosine-protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte)
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Vila-Coro AJ (1999)
JAK2
EG3717
Janus kinase 2|OTTHUMP00000043260|tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase)
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Vila-Coro AJ (1999)
CXCL12
PBSF
SCYB12
SDF-1a
EG6387
stromal cell-derived factor 1 delta|stromal cell-derived factor 1 gamma|stromal cell-derived factor 1a; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
Gene Ontology:
[View List]
Invitro
bait
Salcedo R (1999)
Copyright © 2009,
Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.