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BioGRID | Network Layout for TSC2 for Homo sapiens
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TSC2

 Homo sapiens
The BioGRID Database Seperator
Aliases: LAM, TSC4, FLJ43106, EG7249
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: tuberous sclerosis 2; tuberin
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 11 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with TSC2

TSC2 was identified with 74 protein interactions and 2 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 TSC1
  • KIAA0243
  • LAM
  • MGC86987
  • EG7248
    		•  The BioGRID Database Seperator hamartin|tuberous sclerosis 1 protein|tumor suppressor; tuberous sclerosis 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Dan HC (2002)
    bait/hit Hodges AK (2001)
    bait/hit Aicher LD (2001)
    bait/hit van Slegtenhorst M (1998)
    hit Li Y (2004)
    hit Mak BC (2003)
    bait/hit Ma L (2005)
    hit Cai SL (2006)
    bait/hit Cao Y (2006)
    bait Inoki K (2003)
    bait Goncharova EA (2006)
    bait Astrinidis A (2006)
    bait Astrinidis A (2003)
    bait Nellist M (2001)
    bait Benvenuto G (2000)
    bait Murthy V (2000)
    bait Miloloza A (2000)
    Two-hybrid
    hit Nellist M (2002)
    hit van Slegtenhorst M (1998)
    bait Shumway SD (2003)
    bait Hodges AK (2001)
    Co-localization
    hit van Slegtenhorst M (1998)
    Affinity Capture-MS
    bait Nellist M (2005)
    Co-purification
    bait Nellist M (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHEB
  • RHEB2
  • MGC111559
  • EG6009
    		•  The BioGRID Database Seperator GTP-binding protein Rheb|Ras homolog enriched in brain 2; Ras homolog enriched in brain
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Castro AF (2003)
    bait Long X (2005)
    Biochemical Activity
    hit Inoki K (2003)
    hit Garami A (2003)
    hit Zhang Y (2003)
    hit Cao Y (2006)
    hit Castro AF (2003)
    Reconstituted Complex
    bait Long X (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YWHAA
  • EG7527
    		•  The BioGRID Database Seperator tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; 14-3-3 alpha
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Shumway SD (2003)
    bait/hit Li Y (2002)
    bait Cai SL (2006)
    bait Nellist M (2002)
    hit Li Y (2003)
    Two-hybrid
    hit Nellist M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FOXO1A
  • FKH1
  • FKHR
  • FOXO1
  • EG2308
    		•  The BioGRID Database Seperator forkhead box O1A (rhabdomyosarcoma)|forkhead homolog in rhabdomyosarcoma|forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead box O1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Cao Y (2006)
    Reconstituted Complex
    hit Cao Y (2006)
    Co-localization
    hit Cao Y (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAM
  • PAL
  • PHM
  • EG5066
    		•  The BioGRID Database Seperator pancreatic peptidylglycine alpha-amidating monooxygenase|peptidyl alpha-amidating enzyme|peptidyl-alpha-hydroxyglycine alpha-amidating lyase|peptidylglycine 2-hydroxylase|peptidylglycine alpha-hydroxylating monooxygenase; peptidylglycine alpha-amidating monooxygenase
    Gene Ontology: [View List]
    Two-hybrid
    hit Murthy V (2004)
    Affinity Capture-Western
    bait Murthy V (2004)
    Co-localization
    bait Murthy V (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS6KA1
  • HU-1
  • MAPKAPK1A
  • RSK
  • EG6195
    		•  The BioGRID Database Seperator dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase, 90kD, 1|ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Roux PP (2004)
    Reconstituted Complex
    bait Rolfe M (2005)
    bait Roux PP (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKT1
  • MGC99656
  • PKB
  • PRKBA
  • EG207
    		•  The BioGRID Database Seperator RAC-alpha serine/threonine-protein kinase|murine thymoma viral (v-akt) oncogene homolog-1|protein kinase B|rac protein kinase alpha; v-akt murine thymoma viral oncogene homolog 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Dan HC (2002)
    hit Roux PP (2004)
    Reconstituted Complex
    bait Dan HC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRKAA1
  • AMPK
  • AMPKa1
  • MGC33776
  • EG5562
    		•  The BioGRID Database Seperator 5'-AMP-activated protein kinase, catalytic alpha-1 chain|AMP -activate kinase alpha 1 subunit|AMP-activated protein kinase, catalytic, alpha-1|AMPK alpha 1; protein kinase, AMP-activated, alpha 1 catalytic subunit
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Inoki K (2003)
    Reconstituted Complex
    bait Inoki K (2003)
    bait Shaw RJ (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPK1
  • ERK
  • ERK2
  • ERT1
  • EG5594
    		•  The BioGRID Database Seperator extracellular signal-regulated kinase 2|extracellular signal-regulated kinase-2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2; mitogen-activated protein kinase 1
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Ma L (2005)
    Affinity Capture-Western
    bait Ma L (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • FADK
  • FAK
  • FAK1
  • EG5747
    		•  The BioGRID Database Seperator PTK2 protein tyrosine kinase 2; focal adhesion kinase 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Gan B (2006)
    Reconstituted Complex
    bait/hit Gan B (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSK3B
  • EG2932
    		•  The BioGRID Database Seperator glycogen synthase kinase 3 beta; GSK3beta isoform
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Mak BC (2003)
    Biochemical Activity
    bait Inoki K (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAP1A
  • KREV-1
  • KREV1
  • RAP1
  • EG5906
    		•  The BioGRID Database Seperator OTTHUMP00000059089|RAS-related protein RAP1A|Ras-related protein Krev-1; RAP1A, member of RAS oncogene family
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Castro AF (2003)
    Co-purification
    hit Yamamoto Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YWHAZ
  • KCIP-1
  • MGC111427
  • MGC126532
  • EG7534
    		•  The BioGRID Database Seperator 14-3-3 protein/cytosolic phospholipase A2|14-3-3 zeta|phospholipase A2|protein kinase C inhibitor protein-1|tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
    Gene Ontology: [View List]
    Two-hybrid
    hit Nellist M (2002)
    Reconstituted Complex
    bait Nellist M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PLK1
  • PLK
  • STPK13
  • EG5347
    		•  The BioGRID Database Seperator cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|polo-like kinase; polo-like kinase 1 (Drosophila)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Astrinidis A (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBE3A
  • ANCR
  • AS
  • E6-AP
  • EG7337
    		•  The BioGRID Database Seperator CTCL tumor antigen se37-2|human papilloma virus E6-associated protein|oncogenic protein-associated protein E6-AP|ubiquitin protein ligase E3A; ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Lu Z (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AXIN1
  • AXIN
  • MGC52315
  • LA16c-314...
    		•  The BioGRID Database Seperator axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of; axin 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Mak BC (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDKN1B
  • CDKN4
  • KIP1
  • P27KIP1
  • EG1027
    		•  The BioGRID Database Seperator cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor 1B
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Rosner M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAB5A
  • RAB5
  • EG5868
    		•  The BioGRID Database Seperator RAB5A, member RAS oncogene family; RAS-associated protein RAB5A
    Gene Ontology: [View List]
    Co-purification
    hit Yamamoto Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAV1
  • CAV
  • MSTP085
  • VIP21
  • EG857
    		•  The BioGRID Database Seperator caveolae protein, 22-kD|caveolin 1|caveolin 1 caveolae protein, 22kD|caveolin 1, alpha isoform|caveolin 1, beta isoform|cell growth-inhibiting protein 32; caveolin 1, caveolae protein, 22kDa
    Gene Ontology: [View List]
    Co-purification
    hit Yamamoto Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RALA
  • MGC48949
  • RAL
  • EG5898
    		•  The BioGRID Database Seperator RAS-like protein A|Ras family small GTP binding protein RALA|Ras-related protein Ral-A|ras related v-ral simian leukemia viral oncogene homolog A; v-ral simian leukemia viral oncogene homolog A (ras related)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Castro AF (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCND3
  • EG896
    		•  The BioGRID Database Seperator D3-type cyclin|G1/S-specific cyclin D3; cyclin D3
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zacharek SJ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YWHAQ
  • 1C5
  • HS1
  • 14-3-3
  • EG10971
    		•  The BioGRID Database Seperator 14-3-3 protein T-cell|14-3-3 protein tau|14-3-3 protein theta|protein tau|tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ewing RM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCND1
  • BCL1
  • D11S287E
  • PRAD1
  • EG595
    		•  The BioGRID Database Seperator B-cell CLL/lymphoma 1|G1/S-specific cyclin D1; cyclin D1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zacharek SJ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCND2
  • KIAK0002
  • MGC102758
  • EG894
    		•  The BioGRID Database Seperator G1/S-specific cyclin D2; cyclin D2
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zacharek SJ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Trp53
  • p53
  • bbl
  • bfy
  • RP23-56I2...
    		•  The BioGRID Database Seperator p53 cellular tumor antigen|p53 tumor suppressor|tumor supressor p53; transformation related protein 53
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Zhang H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP2
  • FBL1
  • FBXL1
  • FLB1
  • EG6502
    		•  The BioGRID Database Seperator CDK2/cyclin A-associated protein p45|S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45)
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Rosner M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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