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BioGRID | Network Layout for TP53 for Homo sapiens
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TP53

 Homo sapiens
The BioGRID Database Seperator
Aliases: TRP53, p53, LFS1, EG7157
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: tumor protein p53 (Li-Fraumeni syndrome); p53 tumor suppressor|tumor protein p53
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 40 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with TP53

TP53 was identified with 444 protein interactions and 8 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 MDM2
  • MGC71221
  • hdm2
  • HDMX
  • EG4193
    		•  The BioGRID Database Seperator double minute 2, human homolog of; p53-binding protein|mouse double minute 2 homolog|p53-binding protein MDM2|ubiquitin-protein ligase E3 Mdm2; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
    Gene Ontology: [View List]
    Invivo
    hit Chen J (1993)
    hit Picksley SM (1994)
    hit Momand J (2000)
    Biochemical Activity
    bait Li M (2003)
    bait/hit Fang S (2000)
    Affinity Capture-Western
    bait Latonen L (2001)
    bait/hit Zhang Y (2003)
    hit Kurki S (2003)
    hit Freeman DJ (2003)
    hit Ito A (2002)
    bait/hit Zhang Y (1998)
    hit Buschmann T (2000)
    Reconstituted Complex
    hit Kurki S (2003)
    hit Ito A (2002)
    hit Liu G (2000)
    Co-fractionation
    bait Grossman SR (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BLM
  • BS
  • RECQ2
  • RECQL2
  • EG641
    		•  The BioGRID Database Seperator Bloom syndrome protein; Bloom syndrome
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Sengupta S (2004)
    bait/hit Wang XW (2001)
    bait Garkavtsev IV (2001)
    bait Yang Q (2002)
    Co-localization
    bait Sengupta S (2004)
    bait Wang XW (2001)
    Reconstituted Complex
    bait Wang XW (2001)
    bait Yang Q (2002)
    Two-hybrid
    bait Garkavtsev IV (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TP53BP1
  • 53BP1
  • p202
  • MGC138366
  • EG7158
    		•  The BioGRID Database Seperator tumor protein 53-binding protein, 1|tumor protein p53 binding protein, 1|tumor protein p53-binding protein, 1; tumor protein p53 binding protein 1
    Gene Ontology: [View List]
    Invitro
    bait Derbyshire DJ (2002)
    bait Iwabuchi K (1994)
    Co-crystal Structure
    hit Derbyshire DJ (2002)
    hit Joo WS (2002)
    hit Derbyshire DJ (2002)
    Co-localization
    bait Sengupta S (2004)
    Affinity Capture-Western
    bait Sengupta S (2004)
    bait Lo KW (2005)
    Reconstituted Complex
    hit Ekblad CM (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRCA1
  • BRCAI
  • IRIS
  • PSCP
  • EG672
    		•  The BioGRID Database Seperator BRCA1/BRCA2-containing complex, subunit 1|breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Abramovitch S ()
    bait Ouchi T (1998)
    bait Dong Y (2003)
    bait Chai YL (1999)
    Affinity Capture-MS
    bait Dong Y (2003)
    Reconstituted Complex
    bait Chai YL (1999)
    bait Zhang H (1998)
    Co-purification
    bait Dong Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PML
  • MYL
  • PP8675
  • RNF71
  • EG5371
    		•  The BioGRID Database Seperator promyelocytic leukemia protein|promyelocytic leukemia, inducer of|tripartite motif protein TRIM19; promyelocytic leukemia
    Gene Ontology: [View List]
    Invivo
    bait Guo A (2000)
    bait Fogal V (2000)
    Invitro
    bait Guo A (2000)
    bait Fogal V (2000)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    hit Kurki S (2003)
    Reconstituted Complex
    hit Kurki S (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EP300
  • p300
  • KAT3B
  • RP1-85F18.1
    		•  The BioGRID Database Seperator E1A-associated protein p300|E1A-binding protein, 300kD|OTTHUMP00000028668; E1A binding protein p300
    Gene Ontology: [View List]
    Reconstituted Complex
    hit An W (2004)
    bait Livengood JA (2002)
    bait/hit Grossman SR (1998)
    Biochemical Activity
    bait Livengood JA (2002)
    Affinity Capture-Western
    hit Grossman SR (1998)
    Co-fractionation
    bait Grossman SR (1998)
    Phenotypic Suppression
    hit Pastorcic M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • HRAD51
  • HsRad51
  • HsT16930
  • EG5888
    		•  The BioGRID Database Seperator BRCA1/BRCA2-containing complex, subunit 5|DNA repair protein RAD51 homolog 1|RAD51 homolog protein|RAD51, S.cerevisiae, homolog of, A|RecA, E. coli, homolog of|RecA-like protein|recombination protein A; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Dong Y (2003)
    Co-purification
    bait Dong Y (2003)
    Affinity Capture-Western
    bait Dong Y (2003)
    bait Sturzbecher HW (1996)
    Reconstituted Complex
    hit Sturzbecher HW (1996)
    hit Buchhop S (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATM
  • AT1
  • ATA
  • ATC
  • EG472
    		•  The BioGRID Database Seperator AT complementation group A|AT complementation group C|AT complementation group D|AT complementation group E|AT mutated|AT protein|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein...
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Kang J (2005)
    bait Fabbro M (2004)
    bait Khanna KK (1998)
    Protein-peptide
    bait/hit Kim ST (1999)
    Biochemical Activity
    bait Khanna KK (1998)
    Phenotypic Enhancement
    bait Westphal CH (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIN1
  • DOD
  • UBL5
  • EG5300
    		•  The BioGRID Database Seperator peptidyl-prolyl cis/trans isomerase, NIMA-interacting|prolyl isomerase|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Reconstituted Complex
    bait Wulf GM (2002)
    bait Zacchi P (2002)
    Affinity Capture-Western
    hit Wulf GM (2002)
    bait Zacchi P (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFAP2A
  • AP-2
  • AP2TF
  • TFAP2
  • EG7020
    		•  The BioGRID Database Seperator activating enhancer-binding protein 2 alpha|transcription factor AP-2 alpha|transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha); transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Co-localization
    bait McPherson LA (2002)
    Reconstituted Complex
    hit McPherson LA (2002)
    Two-hybrid
    bait McPherson LA (2002)
    Affinity Capture-Western
    bait McPherson LA (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBE3A
  • ANCR
  • AS
  • E6-AP
  • EG7337
    		•  The BioGRID Database Seperator CTCL tumor antigen se37-2|human papilloma virus E6-associated protein|oncogenic protein-associated protein E6-AP|ubiquitin protein ligase E3A; ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
    Gene Ontology: [View List]
    Invivo
    hit Daniels PR (1997)
    hit Yamamoto Y (1997)
    Invitro
    hit Daniels PR (1997)
    hit Yamamoto Y (1997)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBE2I
  • C358B7.1
  • P18
  • UBC9
  • EG7329
    		•  The BioGRID Database Seperator SUMO-1-protein ligase|ubiquitin carrier protein|ubiquitin conjugating enzyme 9|ubiquitin-conjugating enzyme E2I|ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)|ubiquitin-conjugating enzyme UbcE2A|ubiquitin-like protein SUMO-1 conjugating enzyme|ubiquitin-protein ligas...
    Gene Ontology: [View List]
    Invitro
    bait Shen Z (1996)
    Two-hybrid
    hit Shen Z (1996)
    bait Minty A (2000)
    hit Gallagher WM (1999)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM4
  • DKFZp781B...
  • MDMX
  • MRP1
  • RP11-430C...
    		•  The BioGRID Database Seperator MDM4-related protein 1|double minute 4, human homolog of; p53-binding protein|mouse double minute 4 homolog|p53-binding protein; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
    Gene Ontology: [View List]
    Invivo
    hit Shvarts A (1997)
    hit Parant J (2001)
    Invitro
    hit Shvarts A (1997)
    hit Parant J (2001)
    Biochemical Activity
    bait Badciong JC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STK4
  • DKFZp686A...
  • KRS2
  • MST1
  • EG6789
    		•  The BioGRID Database Seperator dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))|kinase responsive to stress 2|mammalian sterile 20-like 1|yeast Ste20-like; serine/threonine kinase 4
    Gene Ontology: [View List]
    Invivo
    bait Lin Y (2002)
    bait Grigorian M (2003)
    Invitro
    bait Lin Y (2002)
    bait Grigorian M (2003)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     E4F1
  • E4F
  • MGC99614
  • EG1877
    		•  The BioGRID Database Seperator E4F transcription factor 1; p120E4F
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    hit Rizos H (2003)
    hit Sandy P (2000)
    Two-hybrid
    hit Sandy P (2000)
    Reconstituted Complex
    bait Sandy P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PLK3
  • CNK
  • FNK
  • PRK
  • RP11-269F...
    		•  The BioGRID Database Seperator FGF-inducible kinase|cytokine-inducible kinase|polo-like kinase 3|proliferation-related kinase; polo-like kinase 3 (Drosophila)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Biochemical Activity
    bait Xie S (2001)
    bait Bahassi el M (2002)
    Affinity Capture-Western
    hit Xie S (2001)
    bait Bahassi el M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WRN
  • RECQ3
  • RECQL2
  • RECQL3
  • EG7486
    		•  The BioGRID Database Seperator Werner Syndrome helicase|Werner syndrome protein; Werner syndrome
    Gene Ontology: [View List]
    Invivo
    hit Brosh RM (2001)
    Invitro
    hit Brosh RM (2001)
    Affinity Capture-Western
    bait Yang Q (2002)
    Reconstituted Complex
    bait Yang Q (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIF1A
  • HIF-1alpha
  • HIF1-ALPHA
  • MOP1
  • EG3091
    		•  The BioGRID Database Seperator ARNT interacting protein|hypoxia-inducible factor 1, alpha subunit|member of PAS superfamily 1; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    Gene Ontology: [View List]
    Invitro
    bait Hansson LO (2002)
    bait An WG (1998)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    bait Chen D (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRCA2
  • FACD
  • FAD
  • FAD1
  • RP11-298P...
    		•  The BioGRID Database Seperator BRCA1/BRCA2-containing complex, subunit 2|OTTHUMP00000042401|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2; breast cancer 2, early onset
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Dong Y (2003)
    hit Marmorstein LY (1998)
    Affinity Capture-MS
    bait Dong Y (2003)
    Co-purification
    bait Dong Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BAK1
  • BAK
  • BCL2L7
  • CDN1
  • EG578
    		•  The BioGRID Database Seperator BCL2-like 7 protein|Bcl-2 homologous antagonist/killer|OTTHUMP00000039620|apoptosis regulator BAK|pro-apoptotic protein BAK; BCL2-antagonist/killer 1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    hit Leu JI (2004)
    Affinity Capture-Western
    bait/hit Leu JI (2004)
    Reconstituted Complex
    hit Leu JI (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRKDC
  • DNAPK
  • DNPK1
  • HYRC
  • EG5591
    		•  The BioGRID Database Seperator hyper-radiosensitivity of murine scid mutation, complementing 1; protein kinase, DNA-activated, catalytic polypeptide
    Gene Ontology: [View List]
    Invitro
    hit Sheppard HM ()
    Protein-peptide
    bait Kim ST (1999)
    Biochemical Activity
    bait Goudelock DM (2003)
    bait Yavuzer U (1998)
    The BioGRID Database Seperator