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BioGRID | Network Layout for SHC1 for Homo sapiens
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SHC1

 Homo sapiens
The BioGRID Database Seperator
Aliases: FLJ26504, SHC, SHCA, p52SHC, p66SHC, p66, EG6464
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 11 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SHC1

SHC1 was identified with 192 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 GRB2
  • ASH
  • EGFRBP-GRB2
  • Grb3-3
  • EG2885
    		•  The BioGRID Database Seperator HT027|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3; growth factor receptor-bound protein 2
    Gene Ontology: [View List]
    Invivo
    bait Nicholson PR (2001)
    bait Lazar DF (1994)
    bait VanderKuur J (1995)
    Invitro
    bait Nicholson PR (2001)
    bait Lazar DF (1994)
    bait VanderKuur J (1995)
    Affinity Capture-MS
    bait Blagoev B (2003)
    Affinity Capture-Western
    bait/hit Skolnik EY (1993)
    bait Puil L (1994)
    hit Satoh T (1996)
    bait/hit Fixman ED (1996)
    hit Ishihara H (1997)
    hit Fournier E (1999)
    hit Ravichandran KS (1994)
    Reconstituted Complex
    bait Fixman ED (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INPP5D
  • SHIP
  • SHIP1
  • SIP-145
  • EG3635
    		•  The BioGRID Database Seperator SH2 containing inositol phosphatase|SH2 containing inositol phosphatase, isoform b|p150Ship|signaling inositol polyphosphate 5 phosphatase SIP-145; inositol polyphosphate-5-phosphatase, 145kDa
    Gene Ontology: [View List]
    Invivo
    bait Damen JE (1996)
    bait Kavanaugh WM (1996)
    Invitro
    bait Damen JE (1996)
    bait Kavanaugh WM (1996)
    Affinity Capture-Western
    bait/hit Dunant NM (2000)
    hit Wisniewski D (1999)
    hit Leitges M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FLT4
  • FLT41
  • PCL
  • VEGFR3
  • EG2324
    		•  The BioGRID Database Seperator vascular endothelial growth factor receptor 3; fms-related tyrosine kinase 4
    Gene Ontology: [View List]
    Invivo
    bait Fournier E (1995)
    bait Fournier E (1996)
    Invitro
    bait Fournier E (1995)
    bait Fournier E (1996)
    Reconstituted Complex
    bait Pajusola K (1994)
    Affinity Capture-Western
    bait Pajusola K (1994)
    hit Fournier E (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APP
  • AAA
  • ABETA
  • ABPP
  • EG351
    		•  The BioGRID Database Seperator A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|protease nexin-II; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
    Gene Ontology: [View List]
    Invivo
    bait Tarr PE (2002)
    bait Zambrano N (1997)
    Invitro
    bait Tarr PE (2002)
    bait Zambrano N (1997)
    Two-hybrid
    bait Tarr PE (2002)
    bait Zambrano N (1997)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTPN12
  • PTP-PEST
  • PTPG1
  • tcag7.1075
    		•  The BioGRID Database Seperator protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1
    Gene Ontology: [View List]
    Two-hybrid
    bait Habib T (1994)
    Affinity Capture-Western
    hit Charest A (1996)
    bait Habib T (1994)
    Reconstituted Complex
    bait Charest A (1996)
    bait Habib T (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERBB2
  • HER-2
  • HER-2/neu
  • HER2
  • EG2064
    		•  The BioGRID Database Seperator c-erb B2/neu protein|erbB-2|herstatin|neuroblastoma/glioblastoma derived oncogene homolog|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene...
    Gene Ontology: [View List]
    Invivo
    bait Olayioye MA (1998)
    Invitro
    bait Olayioye MA (1998)
    Affinity Capture-MS
    bait Schulze WX (2005)
    Affinity Capture-Western
    hit Wong L (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INPPL1
  • SHIP2
  • EG3636
    		•  The BioGRID Database Seperator inositol polyphosphate phosphatase-like 1; 51C protein
    Gene Ontology: [View List]
    Invitro
    bait Habib T (1998)
    Affinity Capture-Western
    hit Wisniewski D (1999)
    hit Pesesse X (2001)
    Affinity Capture-MS
    hit Wisniewski D (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHCBP1
  • FLJ22009
  • MGC26900
  • PAL
  • EG79801
    		•  The BioGRID Database Seperator SHC SH2-domain binding protein 1
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Rual JF (2005)
    Two-hybrid
    hit Schmandt R (1999)
    Affinity Capture-Western
    hit Schmandt R (1999)
    Reconstituted Complex
    hit Schmandt R (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RET
  • CDHF12
  • HSCR1
  • MEN2A
  • EG5979
    		•  The BioGRID Database Seperator Hirschsprung disease 1|RET transforming sequence|cadherin family member 12|hydroxyaryl-protein kinase|multiple endocrine neoplasia and medullary thyroid carcinoma 1|oncogene RET|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung...
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rual JF (2005)
    Affinity Capture-Western
    hit Arighi E (1997)
    hit Borrello MG (1994)
    Reconstituted Complex
    hit Arighi E (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTRK1
  • MTC
  • TRK
  • TRK1
  • EG4914
    		•  The BioGRID Database Seperator Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A; neurotrophic tyrosine kinase, receptor, type 1
    Gene Ontology: [View List]
    Two-hybrid
    bait Qian X (1998)
    bait Nakamura T (2002)
    Affinity Capture-Western
    hit Borrello MG (1994)
    Reconstituted Complex
    hit Meakin SO (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JAK2
  • EG3717
    		•  The BioGRID Database Seperator Janus kinase 2|OTTHUMP00000043260|tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase)
    Gene Ontology: [View List]
    Invivo
    bait VanderKuur J (1995)
    bait Giordano V (1997)
    Invitro
    bait VanderKuur J (1995)
    bait Giordano V (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPS8
  • EG2059
    		•  The BioGRID Database Seperator epidermal growth factor receptor pathway substrate 8
    Gene Ontology: [View List]
    Invitro
    bait Matoskova B (1995)
    Invivo
    bait Matoskova B (1995)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AP2A1
  • ADTAA
  • AP2-ALPHA
  • CLAPA1
  • EG160
    		•  The BioGRID Database Seperator 100 kDa coated vesicle protein A|adaptin, alpha A|clathrin-associated/assembly/adaptor protein, large, alpha 1; adaptor-related protein complex 2, alpha 1 subunit
    Gene Ontology: [View List]
    Invivo
    bait Sakaguchi K (2001)
    Invitro
    bait Sakaguchi K (2001)
    Affinity Capture-MS
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZAP70
  • SRK
  • STD
  • TZK
  • EG7535
    		•  The BioGRID Database Seperator syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD; zeta-chain (TCR) associated protein kinase 70kDa
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Rual JF (2005)
    Affinity Capture-Western
    bait Pacini S (1998)
    Biochemical Activity
    bait Pacini S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRP1
  • A2MR
  • APOER
  • APR
  • EG4035
    		•  The BioGRID Database Seperator alpha-2-macroglobulin receptor|low density lipoprotein-related protein 1|type V tgf-beta receptor; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Barnes H (2003)
    bait Loukinova E (2002)
    Reconstituted Complex
    hit Barnes H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PLSCR1
  • MMTRA1B
  • EG5359
    		•  The BioGRID Database Seperator phospholipid scramblase 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Nanjundan M (2003)
    hit Sun J (2002)
    Reconstituted Complex
    hit Nanjundan M (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KDR
  • FLK1
  • VEGFR
  • VEGFR2
  • EG3791
    		•  The BioGRID Database Seperator kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2
    Gene Ontology: [View List]
    Two-hybrid
    bait Warner AJ (2000)
    Affinity Capture-Western
    hit Zanetti A (2002)
    bait D'Angelo G (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IL2RB
  • P70-75
  • CD122
  • EG3560
    		•  The BioGRID Database Seperator CD122 antigen|OTTHUMP00000028799|high affinity IL-2 receptor beta subunit|interleukin 2 receptor beta; interleukin 2 receptor, beta
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rual JF (2005)
    Reconstituted Complex
    bait Delespine-Carmagnat M (2000)
    Affinity Capture-Western
    hit Ravichandran KS (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPKAPK2
  • EG9261
    		•  The BioGRID Database Seperator mitogen-activated protein kinase-activated protein kinase 2
    Gene Ontology: [View List]
    Two-hybrid
    bait Yannoni YM (2004)
    Affinity Capture-Western
    hit Yannoni YM (2004)
    Biochemical Activity
    bait Yannoni YM (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AP2A2
  • ADTAB
  • CLAPA2
  • HIP9
  • EG161
    		•  The BioGRID Database Seperator adaptin, alpha B|alpha-adaptin C; Huntingtin interacting protein J|clathrin-associated/assembly/adaptor protein, large, alpha 2; adaptor-related protein complex 2, alpha 2 subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rual JF (2005)
    Affinity Capture-Western
    hit Okabayashi Y (1996)
    Reconstituted Complex
    hit Okabayashi Y (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FCGR2A
  • CD32
  • CDw32
  • FCG2
  • EG2212
    		•  The BioGRID Database Seperator Fc fragment of IgG, low affinity IIa, receptor for (CD32); Fc fragment of IgG, low affinity IIa, receptor (CD32)
    Gene Ontology: [View List]
    Invitro
    bait Koncz G (1999)
    bait Sarmay G (1996)
    Affinity Capture-MS
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FLT1
  • FLT
  • VEGFR1
  • EG2321
    		•  The BioGRID Database Seperator fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
    Gene Ontology: [View List]
    Invivo
    bait Warner AJ (2000)
    Invitro
    bait Warner AJ (2000)
    Two-hybrid
    bait Warner AJ (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Grap2
  • GRAP-2
  • GRB2L
  • GRID
  • EG17444
    		•  The BioGRID Database Seperator Grb2-related adaptor downstream of Sch|monocytic adapter|monocytic adaptor; GRB2-related adaptor protein 2
    Gene Ontology: [View List]
    Co-purification
    hit Liu SK (1998)
    Reconstituted Complex
    bait Liu SK (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOS1
  • GF1
  • GGF1
  • GINGF
  • EG6654
    		•  The BioGRID Database Seperator gingival fibromatosis, hereditary, 1|son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Qian X (2000)
    bait Foehr ED (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FCGR3A
  • CD16
  • CD16a
  • FCG3
  • EG2214
    		•  The BioGRID Database Seperator Fc fragment of IgG, low affinity III, receptor for (CD16)|Fc fragment of IgG, low affinity IIIa, receptor for (CD16)|Fc gamma receptor III-A|Fc-gamma receptor IIIb (CD16)|FcgammaRIIIA; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
    Gene Ontology: [View List]
    Invitro
    bait Galandrini R (1997)
    Affinity Capture-MS
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • FADK
  • FAK
  • FAK1
  • EG5747
    		•  The BioGRID Database Seperator PTK2 protein tyrosine kinase 2; focal adhesion kinase 1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    hit Hecker TP (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IGF1R
  • JTK13
  • CD221
  • IGFIR
  • EG3480
    		•  The BioGRID Database Seperator insulin-like growth factor 1 receptor; clone 1900 unknown protein
    Gene Ontology: [View List]
    Two-hybrid
    bait Dey BR (1996)
    Affinity Capture-Western
    bait Santen RJ (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDGFRB
  • CD140B
  • JTK12
  • PDGF-R-beta
  • EG5159
    		•  The BioGRID Database Seperator beta platelet-derived growth factor receptor|platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
    Gene Ontology: [View List]
    Invivo
    bait Yokote K (1994)
    Affinity Capture-MS
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEACAM1
  • BGP
  • BGP1
  • BGPI
  • EG634
    		•  The BioGRID Database Seperator CD66a antigen|antigen CD66|biliary glycoprotein adhesion molecule|carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit