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BioGRID | Network Layout for PTPN11 for Homo sapiens
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PTPN11

 Homo sapiens
The BioGRID Database Seperator
Aliases: BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, EG5781
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: protein tyrosine phosphatase, non-receptor type 11|protein-tyrosine phosphatase 2C; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 3 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with PTPN11

PTPN11 was identified with 144 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 GRB2
  • ASH
  • EGFRBP-GRB2
  • Grb3-3
  • EG2885
    		•  The BioGRID Database Seperator HT027|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3; growth factor receptor-bound protein 2
    Gene Ontology: [View List]
    Invivo
    hit Minoo P (2003)
    hit Wong L (1996)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    bait Ganju RK (2000)
    bait Bennett AM (1994)
    Far Western
    bait Ward AC (1998)
    Reconstituted Complex
    bait Yin T (1997)
    bait Tang J (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • FADK
  • FAK
  • FAK1
  • EG5747
    		•  The BioGRID Database Seperator PTK2 protein tyrosine kinase 2; focal adhesion kinase 1
    Gene Ontology: [View List]
    Invivo
    bait Miao H (2000)
    bait Retta SF (1996)
    Invitro
    bait Miao H (2000)
    bait Retta SF (1996)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    bait Mañes S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAB2
  • KIAA0571
  • EG9846
    		•  The BioGRID Database Seperator GRB2-associated binding protein 2; Grb2-associated binder 2
    Gene Ontology: [View List]
    Invivo
    hit Liu Y (2001)
    hit Nishida K (1999)
    Invitro
    hit Liu Y (2001)
    hit Nishida K (1999)
    Affinity Capture-Western
    bait/hit Boudot C (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT5A
  • MGF
  • STAT5
  • EG6776
    		•  The BioGRID Database Seperator signal transducer and activator of transcription 5A
    Gene Ontology: [View List]
    Invivo
    hit Chughtai N (2002)
    Invitro
    hit Chughtai N (2002)
    Affinity Capture-MS
    hit Rual JF (2005)
    Reconstituted Complex
    hit Yu CL (2000)
    Biochemical Activity
    hit Yu CL (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRS2
  • FRS2A
  • FRS2alpha
  • SNT
  • EG10818
    		•  The BioGRID Database Seperator FGFR signalling adaptor|suc1-associated neurotrophic factor target; fibroblast growth factor receptor substrate 2
    Gene Ontology: [View List]
    Invivo
    hit Hadari YR (1998)
    Invitro
    hit Hadari YR (1998)
    Affinity Capture-MS
    hit Rual JF (2005)
    Two-hybrid
    bait Delahaye L (2000)
    Affinity Capture-Western
    bait Delahaye L (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLAMF1
  • CD150
  • CDw150
  • SLAM
  • EG6504
    		•  The BioGRID Database Seperator signaling lymphocytic activation molecule family member 1; OTTHUMP00000060252
    Gene Ontology: [View List]
    Invitro
    hit Howie D (2002)
    Invivo
    hit Howie D (2002)
    Two-hybrid
    hit Howie D (2002)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PXN
  • FLJ16691
  • hCG_1778014
    		•  The BioGRID Database Seperator paxillin
    Gene Ontology: [View List]
    Invivo
    bait Miao H (2000)
    bait Retta SF (1996)
    Invitro
    bait Miao H (2000)
    bait Retta SF (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JAK1
  • JAK1A
  • JAK1B
  • EG3716
    		•  The BioGRID Database Seperator Janus kinase 1 (a protein tyrosine kinase); janus kinase 1
    Gene Ontology: [View List]
    Invivo
    bait Carter-Su C (2000)
    Reconstituted Complex
    hit Yin T (1997)
    Biochemical Activity
    bait Yin T (1997)
    Affinity Capture-Western
    hit Lehmann U (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIT
  • C-Kit
  • CD117
  • PBT
  • EG3815
    		•  The BioGRID Database Seperator mast/stem cell growth factor receptor|proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    Gene Ontology: [View List]
    Invivo
    bait Kozlowski M (1998)
    Invitro
    bait Kozlowski M (1998)
    Reconstituted Complex
    hit Tauchi T (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDGFRA
  • CD140A
  • MGC74795
  • PDGFR2
  • EG5156
    		•  The BioGRID Database Seperator FIP1L1/PDGFRA fusion protein|platelet-derived growth factor receptor alpha|rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; platelet-derived growth factor receptor, alpha polypeptide
    Gene Ontology: [View List]
    Invivo
    hit Bazenet CE (1996)
    Invitro
    hit Bazenet CE (1996)
    Affinity Capture-MS
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDGFRB
  • CD140B
  • JTK12
  • PDGF-R-beta
  • EG5159
    		•  The BioGRID Database Seperator beta platelet-derived growth factor receptor|platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
    Gene Ontology: [View List]
    Invitro
    hit Lechleider RJ (1993)
    Affinity Capture-MS
    bait Rual JF (2005)
    Two-hybrid
    bait Keilhack H (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IGF1R
  • JTK13
  • CD221
  • IGFIR
  • EG3480
    		•  The BioGRID Database Seperator insulin-like growth factor 1 receptor; clone 1900 unknown protein
    Gene Ontology: [View List]
    Invitro
    hit Seely BL (1995)
    Invivo
    hit Seely BL (1995)
    Affinity Capture-Western
    bait Mañes S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EGFR
  • ERBB
  • ERBB1
  • mENA
  • EG1956
    		•  The BioGRID Database Seperator avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
    Gene Ontology: [View List]
    Invitro
    bait Tomic S (1995)
    Invivo
    bait Tomic S (1995)
    Affinity Capture-MS
    bait Schulze WX (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INSR
  • CD220
  • HHF5
  • EG3643
    		•  The BioGRID Database Seperator insulin receptor
    Gene Ontology: [View List]
    Invivo
    bait Kharitonenkov A (1995)
    Invitro
    bait Kharitonenkov A (1995)
    Reconstituted Complex
    bait Maegawa H (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPZL1
  • FLJ21047
  • PZR
  • PZR1b
  • EG9019
    		•  The BioGRID Database Seperator immunoglobulin family transmembrane protein|myelin protein zero-like protein MPZL1b|protein zero related; myelin protein zero-like 1
    Gene Ontology: [View List]
    Invivo
    hit Zhao ZJ (1998)
    Invitro
    hit Zhao ZJ (1998)
    Affinity Capture-MS
    hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JAK2
  • EG3717
    		•  The BioGRID Database Seperator Janus kinase 2|OTTHUMP00000043260|tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase)
    Gene Ontology: [View List]
    Invivo
    bait Maegawa H (1996)
    Reconstituted Complex
    hit Yin T (1997)
    Biochemical Activity
    bait Yin T (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEACAM1
  • BGP
  • BGP1
  • BGPI
  • EG634
    		•  The BioGRID Database Seperator CD66a antigen|antigen CD66|biliary glycoprotein adhesion molecule|carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    Gene Ontology: [View List]
    Invitro
    bait Huber M (1999)
    bait Budt M (2002)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT1
  • SIT
  • RP11-331F...
  • MGC125908
  • EG27240
    		•  The BioGRID Database Seperator SHP2 interacting transmembrane adaptor|SHP2-interacting transmembrane adaptor protein|suppression inducing transmembrane adaptor 1; signaling threshold regulating transmembrane adaptor 1
    Gene Ontology: [View List]
    Invivo
    bait Marie-Cardine A (1999)
    bait Pfrepper KI (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPHA2
  • ECK
  • EG1969
    		•  The BioGRID Database Seperator ephrin receptor EphA2|epithelial cell receptor protein tyrosine kinase|protein tyrosine kinase|receptor protein tyrosine kinase regulated by p53 and E2F-1; EPH receptor A2
    Gene Ontology: [View List]
    Invivo
    bait Miao H (2000)
    Invitro
    bait Miao H (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAV1
  • CAV
  • MSTP085
  • VIP21
  • EG857
    		•  The BioGRID Database Seperator caveolae protein, 22-kD|caveolin 1|caveolin 1 caveolae protein, 22kD|caveolin 1, alpha isoform|caveolin 1, beta isoform|cell growth-inhibiting protein 32; caveolin 1, caveolae protein, 22kDa
    Gene Ontology: [View List]
    Invivo
    hit Caselli A (2002)
    Affinity Capture-MS
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INPP5D
  • SHIP
  • SHIP1
  • SIP-145
  • EG3635
    		•  The BioGRID Database Seperator SH2 containing inositol phosphatase|SH2 containing inositol phosphatase, isoform b|p150Ship|signaling inositol polyphosphate 5 phosphatase SIP-145; inositol polyphosphate-5-phosphatase, 145kDa
    Gene Ontology: [View List]
    Invitro
    bait Liu L (1997)
    Invivo
    bait Liu L (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2B
  • CADTK
  • CAKB
  • FADK2
  • EG2185
    		•  The BioGRID Database Seperator CAK beta|calcium-dependent tyrosine kinase|cell adhesion kinase beta|focal adhesion kinase 2|proline-rich tyrosine kinase 2|protein kinase B|protein tyrosine kinase 2 beta|related adhesion focal tyrosine kinase; PTK2B protein tyrosine kinase 2 beta
    Gene Ontology: [View List]
    Invivo
    bait Chauhan D (2000)
    Invitro
    bait Chauhan D (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT5B
  • STAT5
  • EG6777
    		•  The BioGRID Database Seperator signal transducer and activator of transcription 5B; transcription factor STAT5B
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Yu CL (2000)
    Biochemical Activity
    hit Yu CL (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOCS3
  • CIS3
  • Cish3
  • MGC71791
  • EG9021
    		•  The BioGRID Database Seperator STAT induced STAT inhibitor 3|cytokine-induced SH2 protein 3; suppressor of cytokine signaling 3
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lehmann U (2003)
    Reconstituted Complex
    hit Lehmann U (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRS1
  • HIRS-1
  • EG3667
    		•  The BioGRID Database Seperator insulin receptor substrate 1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Kuhne MR (1993)
    Affinity Capture-Western
    hit Myers MG (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSF2RB
  • CD131
  • CDw131
  • IL3RB
  • EG1439
    		•  The BioGRID Database Seperator Colony-stimulating factor-2 receptor, beta, low-affinity|interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity); colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bone H (1997)
    Reconstituted Complex
    bait Bone H (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT3
  • APRF
  • FLJ20882
  • MGC16063
  • EG6774
    		•  The BioGRID Database Seperator DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Rual JF (2005)
    Affinity Capture-Western
    bait Gunaje JJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IL6ST
  • CD130
  • CDw130
  • GP130
  • EG3572
    		•  The BioGRID Database Seperator CD130 antigen|IL6ST nirs variant 3|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130 transducer chain|interleukin 6 signal transducer|interleukin receptor beta chain|membrane glycoprotein gp130|oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin...
    Gene Ontology: [View List]
    Invivo
    bait Anhuf D (2000)
    Affinity Capture-Western
    bait Lehmann U (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIE1
  • JTK14
  • TIE
  • RP11-282K...
    		•  The BioGRID Database Seperator receptor tyrosine kinase|tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1
    Gene Ontology: [View List]
    Invivo
    hit Marron MB (2000)
    Affinity Capture-MS
    hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIGLEC7
  • AIRM1
  • QA79
  • SIGLEC-7
  • EG27036
    		•  The BioGRID Database Seperator adhesion inhibitory receptor molecule 1, siglec-7|sialic acid binding immunoglobulin-like lectin 7; sialic acid binding Ig-like lectin 7
    Gene Ontology: [View List]
    Invitro
    bait Falco M (1999)
    Invivo
    bait Falco M (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF1A
  • CD120a
  • FPF
  • MGC19588
  • EG7132
    		•  The BioGRID Database Seperator tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor; tumor necrosis factor receptor superfamily, member 1A
    Gene Ontology: [View List]
    Invivo
    bait Daigle I (2002)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PECAM1
  • CD31
  • PECAM-1
  • EG5175
    		•  The BioGRID Database Seperator platelet/endothelial cell adhesion molecule (CD31 antigen); CD31/EndoCAM|PECAM-1, CD31/EndoCAM|adhesion molecule
    Gene Ontology: [View List]
    Invivo
    hit Jackson DE (1997)
    Invitro
    hit Jackson DE (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTLA4
  • CD152
  • CTLA-4
  • CELIAC3
  • EG1493
    		•  The BioGRID Database Seperator cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; cytotoxic T-lymphocyte-associated protein 4
    Gene Ontology: [View List]
    Invivo
    bait Marengere LE (1996)
    Invitro
    bait Marengere LE (1996)