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BioGRID | Network Layout for EIF2AK2 for Homo sapiens
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EIF2AK2

 Homo sapiens
The BioGRID Database Seperator
Aliases: EIF2AK1, PKR, PRKR, MGC126524, EG5610
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: double stranded RNA activated protein kinase|interferon-inducible elF2alpha kinase|protein kinase, interferon-inducible double stranded RNA dependent; eukaryotic translation initiation factor 2-alpha kinase 2
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with EIF2AK2

EIF2AK2 was identified with 49 protein interactions and 1 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ILF3
  • DRBF
  • DRBP76
  • MMP4
  • EG3609
    		•  The BioGRID Database Seperator M-phase phosphoprotein 4|double-stranded RNA-binding protein, 76 kD|dsRNA binding protein NFAR-2/MPP4|interleukin enhancer binding factor 3|nuclear factor associated with dsRNA|nuclear factor of activated T-cells, 90 kD|translational control protein 80; interleukin enhancer binding factor 3, 90kDa
    Gene Ontology: [View List]
    Two-hybrid
    hit Saunders LR (2001)
    hit Patel RC (1999)
    Reconstituted Complex
    bait/hit Saunders LR (2001)
    bait/hit Parker LM (2001)
    hit Patel RC (1999)
    Affinity Capture-Western
    bait/hit Saunders LR (2001)
    bait/hit Parker LM (2001)
    bait Patel RC (1999)
    Biochemical Activity
    hit Saunders LR (2001)
    hit Langland JO (1999)
    hit Parker LM (2001)
    hit Patel RC (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRKRA
  • HSD14
  • PACT
  • RAX
  • EG8575
    		•  The BioGRID Database Seperator protein kinase, interferon-inducible double stranded RNA dependent activator; protein activator of the interferon-induced protein kinase
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Huang X (2002)
    bait Patel RC (1998)
    Affinity Capture-Western
    bait Patel RC (1998)
    Two-hybrid
    hit Patel RC (1998)
    Phenotypic Enhancement
    bait Patel RC (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPP1CA
  • MGC15877
  • MGC1674
  • PP-1A
  • EG5499
    		•  The BioGRID Database Seperator protein phosphatase 1, catalytic subunit, alpha|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; protein phosphatase 1, catalytic subunit, alpha isoform
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Tan SL (2002)
    Reconstituted Complex
    bait Tan SL (2002)
    Biochemical Activity
    bait Tan SL (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TP53
  • TRP53
  • p53
  • LFS1
  • EG7157
    		•  The BioGRID Database Seperator tumor protein p53 (Li-Fraumeni syndrome); p53 tumor suppressor|tumor protein p53
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Cuddihy AR (1999)
    Reconstituted Complex
    bait/hit Cuddihy AR (1999)
    Biochemical Activity
    hit Cuddihy AR (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNAJC3
  • HP58
  • P58
  • P58IPK
  • EG5611
    		•  The BioGRID Database Seperator protein-kinase, interferon-inducible double stranded RNA dependent inhibitor; DnaJ (Hsp40) homolog, subfamily C, member 3
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Polyak SJ (1996)
    bait Gale M (1998)
    Two-hybrid
    bait Gale M (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TARBP2
  • TRBP
  • TRBP1
  • TRBP2
  • EG6895
    		•  The BioGRID Database Seperator TAR (HIV) RNA binding protein 2|TAR (HIV) RNA-binding protein 2|TAR (HIV) RNA-binding protein TRBP1|TAR RNA binding protein 2|TAR RNA-binding protein 2|trans-activation responsive RNA-binding protein; Tar (HIV-1) RNA binding protein 2
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Cosentino GP (1995)
    bait/hit Daher A (2001)
    Far Western
    bait/hit Cosentino GP (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EIF2AK2
  • EIF2AK1
  • PKR
  • PRKR
  • EG5610
    		•  The BioGRID Database Seperator double stranded RNA activated protein kinase|interferon-inducible elF2alpha kinase|protein kinase, interferon-inducible double stranded RNA dependent; eukaryotic translation initiation factor 2-alpha kinase 2
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Cosentino GP (1995)
    Far Western
    bait/hit Cosentino GP (1995)
    Affinity Capture-Western
    bait/hit Bonnet MC (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     METAP2
  • MNPEP
  • p67
  • p67eIF2
  • EG10988
    		•  The BioGRID Database Seperator eIF-2-associated p67 homolog|initiation factor 2-associated 67 kDa glycoprotein|peptidase M 2; methionyl aminopeptidase 2
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gil J (2000)
    Reconstituted Complex
    bait Gil J (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT1
  • DKFZp686B...
  • ISGF-3
  • STAT91
  • EG6772
    		•  The BioGRID Database Seperator signal transducer and activator of transcription 1|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription 1, 91kDa
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Wong AH (1997)
    Reconstituted Complex
    hit Wong AH (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEBP
  • P23
  • PTGES3
  • cPGES
  • EG10728
    		•  The BioGRID Database Seperator cytosolic prostaglandin E synthase|unactive progesterone receptor, 23 kD; prostaglandin E synthase 3 (cytosolic)
    Gene Ontology: [View List]
    Invitro
    hit Donze O (2001)
    Invivo
    hit Donze O (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHUK
  • IKBKA
  • IKK-alpha
  • IKK1
  • EG1147
    		•  The BioGRID Database Seperator I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|conserved helix-loop ubiquitous kinase; conserved helix-loop-helix ubiquitous kinase
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Bonnet MC (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IKBKB
  • IKK-beta
  • IKK2
  • IKKB
  • EG3551
    		•  The BioGRID Database Seperator inhibitor of nuclear factor kappa B kinase beta subunit|nuclear factor NF-kappa-B inhibitor kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Bonnet MC (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIST2H2AC
  • H2A
  • H2A-GL101
  • H2A/q
  • EG8338
    		•  The BioGRID Database Seperator H2A histone family, member Q|histone 2, H2ac|histone IIa; histone cluster 2, H2ac
    Gene Ontology: [View List]
    Biochemical Activity
    hit Gale M (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT3
  • APRF
  • FLJ20882
  • MGC16063
  • EG6774
    		•  The BioGRID Database Seperator DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor)
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Deb A (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDGFRB
  • CD140B
  • JTK12
  • PDGF-R-beta
  • EG5159
    		•  The BioGRID Database Seperator beta platelet-derived growth factor receptor|platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Deb A (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP3K5
  • ASK1
  • MAPKKK5
  • MEKK5
  • RP3-325F2...
    		•  The BioGRID Database Seperator MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|apoptosis signal regulating kinase; mitogen-activated protein kinase kinase kinase 5
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Takizawa T (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBNL
  • HIP-55
  • SH3P7
  • ABP1
  • EG28988
    		•  The BioGRID Database Seperator src homology 3 domain-containing protein HIP-55; drebrin-like
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ewing RM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRKRIP1
  • C114
  • FLJ13902
  • FLJ40957
  • EG79706
    		•  The BioGRID Database Seperator likely ortholog of mouse C114 dsRNA-binding protein; PRKR interacting protein 1 (IL11 inducible)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Yin Z (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSPCA
  • FLJ31884
  • HSP86
  • HSP90A
  • EG3320
    		•  The BioGRID Database Seperator heat shock 90kD protein 1, alpha|heat shock 90kD protein 1, alpha-like 4|heat shock 90kD protein, alpha-like 4|heat shock 90kDa protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1
    Gene Ontology: [View List]
    Invivo
    hit Donze O (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FANCC
  • FA3
  • FAC
  • FACC
  • RP11-80I1...
    		•  The BioGRID Database Seperator bA80I15.1 (Fanconi anemia, complementation group C, protein); Fanconi anemia, complementation group C
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pang Q (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPP2R5A
  • MGC131915
  • B56A
  • PR61A
  • EG5525
    		•  The BioGRID Database Seperator PP2A, B subunit, B' alpha isoform|PP2A, B subunit, B56 alpha isoform|PP2A, B subunit, PR61 alpha isoform|PP2A, B subunit, R5 alpha isoform|protein phosphatase 2, regulatory subunit B (B56), alpha isoform|serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform; protein...
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Xu Z (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ILF2
  • MGC8391
  • NF45
  • PRO3063
  • EG3608
    		•  The BioGRID Database Seperator interleukin enhancer binding factor 2|nuclear factor of activated T-cells, 45-kDa; interleukin enhancer binding factor 2, 45kDa
    Gene Ontology: [View List]
    Biochemical Activity
    hit Parker LM (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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