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BioGRID | Network Layout for MAPK8 for Homo sapiens
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MAPK8

 Homo sapiens
The BioGRID Database Seperator
Aliases: JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, EG5599
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: JNK1 alpha protein kinase|JNK1 beta protein kinase|c-Jun N-terminal kinase 1|protein kinase JNK1|stress-activated protein kinase JNK1; mitogen-activated protein kinase 8
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with MAPK8

MAPK8 was identified with 94 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 MAPK8IP3
  • DKFZp762N...
  • FLJ00027
  • JIP3
  • AC012180.8
    		•  The BioGRID Database Seperator C-jun-amino-terminal kinase interacting protein 3|JNK-interacting protein 3|JNK/SAPK-associated protein-1|JNK/stress-activated protein kinase-associated protein 1|homolog of Drosophila Sunday driver 2; mitogen-activated protein kinase 8 interacting protein 3
    Gene Ontology: [View List]
    Invivo
    bait Ito M (1999)
    bait Kelkar N (2000)
    bait Matsuura H (2002)
    Invitro
    bait Ito M (1999)
    bait Kelkar N (2000)
    bait Matsuura H (2002)
    Two-hybrid
    bait Ito M (1999)
    bait Kelkar N (2000)
    bait Matsuura H (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATF2
  • CRE-BP1
  • CREB2
  • HB16
  • EG1386
    		•  The BioGRID Database Seperator activating transcription factor 2 splice variant ATF2-var2|cAMP responsive element binding protein 2, formerly; activating transcription factor 2
    Gene Ontology: [View List]
    Invivo
    bait van Dam H (1995)
    bait Livingstone C (1995)
    Invitro
    bait van Dam H (1995)
    bait Livingstone C (1995)
    Reconstituted Complex
    bait Raingeaud J (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JUN
  • AP1
  • c-Jun
  • EG3725
    		•  The BioGRID Database Seperator Jun activation domain binding protein|activator protein 1|enhancer-binding protein AP1|v-jun avian sarcoma virus 17 oncogene homolog|v-jun sarcoma virus 17 oncogene homolog; jun oncogene
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ishitani T (2003)
    hit Nishitoh H (1998)
    hit Derijard B (1994)
    Reconstituted Complex
    bait Derijard B (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRS1
  • HIRS-1
  • EG3667
    		•  The BioGRID Database Seperator insulin receptor substrate 1
    Gene Ontology: [View List]
    Invivo
    hit Aguirre V (2000)
    Invitro
    hit Aguirre V (2000)
    Two-hybrid
    hit Aguirre V (2002)
    hit Aguirre V (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SH3BP5
  • SAB
  • EG9467
    		•  The BioGRID Database Seperator SH3-domain binding protein 5 (BTK-associated); SH3 binding protein
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Wiltshire C (2002)
    Two-hybrid
    hit Wiltshire C (2002)
    Biochemical Activity
    hit Wiltshire C (2002)
    Co-localization
    bait Wiltshire C (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IKBKAP
  • DKFZp781H...
  • DYS
  • FD
  • RP11-3J11.4
    		•  The BioGRID Database Seperator OTTHUMP00000063889|dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type III); inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
    Gene Ontology: [View List]
    Two-hybrid
    hit Holmberg C (2002)
    Affinity Capture-Western
    hit Holmberg C (2002)
    Reconstituted Complex
    hit Holmberg C (2002)
    Biochemical Activity
    hit Holmberg C (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP2K4
  • JNKK
  • JNKK1
  • MAPKK4
  • EG6416
    		•  The BioGRID Database Seperator JNK activating kinase 1|JNK-activated kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4
    Gene Ontology: [View List]
    Invitro
    bait Yang J (1998)
    bait Fleming Y (2000)
    Reconstituted Complex
    bait Lee CM (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP3K1
  • MAPKKK1
  • MEKK
  • MEKK1
  • EG4214
    		•  The BioGRID Database Seperator MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1; mitogen-activated protein kinase kinase kinase 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Xu S (1997)
    Reconstituted Complex
    bait Xu S (1997)
    Biochemical Activity
    hit Xu S (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUSP22
  • JKAP
  • JSP1
  • MKPX
  • EG56940
    		•  The BioGRID Database Seperator JNK-stimulating phosphatase 1|homolog of mouse dual specificity phosphatase LMW-DSP2|mitogen-activated protein kinase phosphatase x; dual specificity phosphatase 22
    Gene Ontology: [View List]
    Biochemical Activity
    bait Aoyama K (2001)
    Affinity Capture-Western
    bait Aoyama K (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPIB
  • SPI-B
  • EG6689
    		•  The BioGRID Database Seperator Spi-B transcription factor (Spi-1/PU.1 related)
    Gene Ontology: [View List]
    Co-purification
    bait Mao C (1996)
    Biochemical Activity
    hit Mao C (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUSP10
  • MKP-5
  • MKP5
  • EG11221
    		•  The BioGRID Database Seperator dual specificity phosphatase MKP-5|map kinase phosphatase 5|serine/threonine specific protein phosphatase; dual specificity phosphatase 10
    Gene Ontology: [View List]
    Invitro
    bait Tanoue T (1999)
    Two-hybrid
    bait Tanoue T (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP3K7
  • TAK1
  • TGF1a
  • EG6885
    		•  The BioGRID Database Seperator TGF-beta activated kinase 1|transforming growth factor-beta-activated kinase 1; mitogen-activated protein kinase kinase kinase 7
    Gene Ontology: [View List]
    Invivo
    bait Sanna MG (2002)
    Invitro
    bait Sanna MG (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMAD3
  • DKFZP586N...
  • DKFZp686J...
  • HSPC193
  • EG4088
    		•  The BioGRID Database Seperator MAD, mothers against decapentaplegic homolog 3|SMA- and MAD-related protein 3|SMAD, mothers against DPP homolog 3|mad homolog JV15-2|mad protein homolog|mothers against decapentaplegic homolog 3; SMAD family member 3
    Gene Ontology: [View List]
    Invivo
    hit Engel ME (1999)
    Invitro
    hit Engel ME (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP3K2
  • MEKK2
  • MEKK2B
  • EG10746
    		•  The BioGRID Database Seperator MAP/ERK kinase kinase 2|MAPK/ERK kinase kinase 2|MEK kinase 2; mitogen-activated protein kinase kinase kinase 2
    Gene Ontology: [View List]
    Invivo
    hit Cheng J (2000)
    Invitro
    hit Cheng J (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP2K7
  • Jnkk2
  • MAPKK7
  • MKK7
  • EG5609
    		•  The BioGRID Database Seperator JNK kinase 2|JNK-activating kinase 2|MAP kinase kinase 7|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7
    Gene Ontology: [View List]
    Invivo
    bait Tournier C (1997)
    Invitro
    bait Tournier C (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYC
  • c-Myc
  • EG4609
    		•  The BioGRID Database Seperator avian myelocytomatosis viral oncogene homolog|myc proto-oncogene protein|v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian)
    Gene Ontology: [View List]
    Invivo
    hit Noguchi K (1999)
    Invitro
    hit Noguchi K (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAX2
  • EG5076
    		•  The BioGRID Database Seperator paired box gene 2|paired box homeotic gene 2|paired box protein 2; paired box 2
    Gene Ontology: [View List]
    Invivo
    hit Cai Y (2002)
    Invitro
    hit Cai Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REL
  • C-Rel
  • EG5966
    		•  The BioGRID Database Seperator C-Rel proto-oncogene protein|oncogene REL, avian reticuloendotheliosis|v-rel avian reticuloendotheliosis viral oncogene homolog|v-rel reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian)
    Gene Ontology: [View List]
    Invivo
    bait Meyer CF (1996)
    Two-hybrid
    bait Meyer CF (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JUNB
  • EG3726
    		•  The BioGRID Database Seperator jun B proto-oncogene
    Gene Ontology: [View List]
    Invivo
    bait Fuchs SY (1997)
    Invitro
    bait Fuchs SY (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRCC6
  • CTC75
  • CTCBF
  • G22P1
  • EG2547
    		•  The BioGRID Database Seperator ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|Ku autoantigen p70 subunit|OTTHUMP00000028581|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70; X-ray repair complementing defective repair in Chinese...
    Gene Ontology: [View List]
    Invitro
    hit Park SJ (2001)
    Invivo
    hit Park SJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSTP1
  • DFN7
  • FAEES3
  • GST3
  • EG2950
    		•  The BioGRID Database Seperator deafness, X-linked 7|fatty acid ethyl ester synthase III|glutathione transferase; glutathione S-transferase pi
    Gene Ontology: [View List]
    Invivo
    hit Wang T (2001)
    Invitro
    hit Wang T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRKDC
  • DNAPK
  • DNPK1
  • HYRC
  • EG5591
    		•  The BioGRID Database Seperator hyper-radiosensitivity of murine scid mutation, complementing 1; protein kinase, DNA-activated, catalytic polypeptide
    Gene Ontology: [View List]
    Invivo
    bait Park SJ (2001)
    Invitro
    bait Park SJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRK
  • CRKII
  • EG1398
    		•  The BioGRID Database Seperator avian sarcoma virus CT10 (v-crk) oncogene homolog|v-crk avian sarcoma virus CT10 oncogene homolog|v-crk sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Girardin SE (2001)
    Reconstituted Complex
    hit Girardin SE (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF1A
  • CD120a
  • FPF
  • MGC19588
  • EG7132
    		•  The BioGRID Database Seperator tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor; tumor necrosis factor receptor superfamily, member 1A
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPI1
  • OF
  • PU.1
  • SPI-A
  • hCG_25181
    		•  The BioGRID Database Seperator 31 kDa transforming protein|SPI-1 proto-oncogene|hematopoietic transcription factor PU.1; spleen focus forming virus (SFFV) proviral integration oncogene spi1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Mao C (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Dusp22
  • 1110028K0...
  • JKAP
  • JSP1
  • EG105352
    		•  The BioGRID Database Seperator dual specificity phosphatase TS-DSP2; dual specificity phosphatase 22
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Chen AJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNCA
  • NACP
  • PARK1
  • PARK4
  • EG6622
    		•  The BioGRID Database Seperator alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid; synuclein, alpha (non A4 component of amyloid precursor)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pan ZZ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPAG9
  • FLJ13450
  • FLJ14006
  • FLJ34602
  • EG9043
    		•  The BioGRID Database Seperator HLC-4 protein|JNK interacting protein|JNK-associated leucine-zipper protein|JNK/SAPK-associated protein|Max-binding protein|c-Jun NH2-terminal kinase-associated leucine zipper protein|lung cancer oncogene 4|proliferation-inducing gene 6|sperm specific protein|sperm surface protein; sperm associated...
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lee CM (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CASP8
  • FLICE
  • MACH
  • MCH5
  • EG841
    		•  The BioGRID Database Seperator FADD-homologous ICE/CED-3-like protease|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|Mch5 isoform alpha|caspase 8|caspase 8, apoptosis-related cysteine protease|cysteine protease|procaspase-8; caspase 8, apoptosis-related cysteine peptidase
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCAR1
  • CAS
  • CRKAS
  • P130Cas
  • EG9564
    		•  The BioGRID Database Seperator breast cancer anti-estrogen resistance 1; Crk-associated substrate p130Cas
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Girardin SE (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNCG
  • BCSG1
  • SR
  • EG6623
    		•  The BioGRID Database Seperator breast cancer-specific protein 1|persyn|synoretin|synuclein, gamma (breast cancer-specific gene 1); synuclein, gamma (breast cancer-specific protein 1)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pan ZZ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRKD1
  • PKC-MU
  • PKCM
  • PKD
  • EG5587
    		•  The BioGRID Database Seperator protein kinase C, mu; protein kinase D1
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Hurd C (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Rps6kb1
  • 2610318I1...
  • 70kDa
  • S6K1
  • RP23-467J...
    		•  The BioGRID Database Seperator ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Zhang Y (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FADD
  • GIG3
  • MGC8528
  • MORT1
  • EG8772
    		•  The BioGRID Database Seperator Fas-associated via death domain|Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor-induced toxicity; Fas (TNFRSF6)-associated via death domain
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPK8IP1
  • IB1
  • JIP-1
  • PRKM8IP
  • EG9479
    		•  The BioGRID Database Seperator JNK-interacting protein 1|PRKM8 interacting protein|islet-brain 1; mitogen-activated protein kinase 8 interacting protein 1
    Gene Ontology: [View List]
    Invivo
    bait Whitmarsh AJ (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPK8IP2
  • IB2
  • JIP2
  • PRKM8IPL
  • EG23542
    		•  The BioGRID Database Seperator JNK MAP kinase scaffold protein JIP2|JNK-interacting protein 2|PRKM8 interacting protein-like|homologous to mouse JIP-1|islet-brain 2; mitogen-activated protein kinase 8 interacting protein 2
    Gene Ontology: [View List]
    Invitro
    bait Negri S (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUSP16
  • KIAA1700
  • MKP-7
  • MKP7
  • EG80824
    		•  The BioGRID Database Seperator dual specificity phosphatase 16; MAPK phosphatase-7
    Gene Ontology: [View List]
    Invivo
    bait Masuda K (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DUSP1
  • CL100
  • HVH1
  • MKP-1
  • EG1843
    		•  The BioGRID Database Seperator serine/threonine specific protein phosphatase; dual specificity phosphatase 1
    Gene Ontology: [View List]
    Two-hybrid
    bait Slack DN (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TP53
  • TRP53
  • p53
  • LFS1
  • EG7157
    		•  The BioGRID Database Seperator tumor protein p53 (Li-Fraumeni syndrome); p53 tumor suppressor|tumor protein p53
    Gene Ontology: [View List]
    Invivo
    bait Hu MC (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JUND
  • EG3727
    		•  The BioGRID Database Seperator JunD-FL isoform|transcription factor jun-D; jun D proto-oncogene
    Gene Ontology: [View List]
    Invitro
    bait Yazgan O (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRAS
  • HRAS1
  • K-ras
  • N-ras
  • EG3265
    		•  The BioGRID Database Seperator H-RasIDX|c-has/bas p21 protein|c-ras-Ki-2 protein|p21 protein; v-Ha-ras Harvey rat sarcoma viral oncogene homolog
    Gene Ontology: [View List]
    Invivo
    hit Ranginwale M (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFSF11
  • ODF
  • OPGL
  • RANKL
  • EG8600
    		•  The BioGRID Database Seperator TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|tumor necrosis factor ligand superfamily, member 11; tumor necrosis factor (ligand) superfamily, member 11
    Gene Ontology: [View List]
    Invivo
    bait Wong BR (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF10B
  • DR5
  • KILLER
  • KILLER/DR5
  • EG8795
    		•  The BioGRID Database Seperator Fas-like protein|TNF-related apoptosis-inducing ligand receptor 2|TRAIL receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA damage-inducible cell...
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)