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BioGRID | Network Layout for PRKDC for Homo sapiens
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PRKDC

 Homo sapiens
The BioGRID Database Seperator
Aliases: DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, EG5591
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: hyper-radiosensitivity of murine scid mutation, complementing 1; protein kinase, DNA-activated, catalytic polypeptide
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 3 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with PRKDC

PRKDC was identified with 59 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 XRCC5
  • KARP-1
  • KARP1
  • KU80
  • EG7520
    		•  The BioGRID Database Seperator ATP-dependent DNA helicase II|DNA repair protein XRCC5|Ku86 autoantigen related protein 1|X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)|X-ray repair, complementing defective, repair in Chinese hamster; X-ray repair...
    Gene Ontology: [View List]
    Invivo
    hit Gell D (1999)
    Invitro
    hit Gell D (1999)
    Reconstituted Complex
    bait Jin S (1997)
    Affinity Capture-Western
    bait Matheos D (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     C1D
  • MGC12261
  • MGC14659
  • SUNCOR
  • EG10438
    		•  The BioGRID Database Seperator C1D DNA-binding protein|small unique nuclear receptor corepressor; nuclear DNA-binding protein
    Gene Ontology: [View List]
    Two-hybrid
    hit Yavuzer U (1998)
    Reconstituted Complex
    bait Yavuzer U (1998)
    Biochemical Activity
    hit Yavuzer U (1998)
    Affinity Capture-Western
    hit Yavuzer U (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TP53
  • TRP53
  • p53
  • LFS1
  • EG7157
    		•  The BioGRID Database Seperator tumor protein p53 (Li-Fraumeni syndrome); p53 tumor suppressor|tumor protein p53
    Gene Ontology: [View List]
    Invitro
    bait Sheppard HM ()
    Protein-peptide
    hit Kim ST (1999)
    Biochemical Activity
    hit Goudelock DM (2003)
    hit Yavuzer U (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA2
  • REPA2
  • RPA32
  • EG6118
    		•  The BioGRID Database Seperator replication protein A2, 32kDa; replication protein A2 (32kD)
    Gene Ontology: [View List]
    Invitro
    hit Wang H (2001)
    Affinity Capture-Western
    bait/hit Shao RG (1999)
    Reconstituted Complex
    hit Shao RG (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WRN
  • RECQ3
  • RECQL2
  • RECQL3
  • EG7486
    		•  The BioGRID Database Seperator Werner Syndrome helicase|Werner syndrome protein; Werner syndrome
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    Affinity Capture-Western
    bait Karmakar P (2002)
    Biochemical Activity
    hit Karmakar P (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     XRCC6
  • CTC75
  • CTCBF
  • G22P1
  • EG2547
    		•  The BioGRID Database Seperator ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|Ku autoantigen p70 subunit|OTTHUMP00000028581|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70; X-ray repair complementing defective repair in Chinese...
    Gene Ontology: [View List]
    Invivo
    hit Gell D (1999)
    Invitro
    hit Gell D (1999)
    Affinity Capture-Western
    hit Shao RG (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHUK
  • IKBKA
  • IKK-alpha
  • IKK1
  • EG1147
    		•  The BioGRID Database Seperator I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|conserved helix-loop ubiquitous kinase; conserved helix-loop-helix ubiquitous kinase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Liu L (1998)
    Reconstituted Complex
    bait Liu L (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ILF2
  • MGC8391
  • NF45
  • PRO3063
  • EG3608
    		•  The BioGRID Database Seperator interleukin enhancer binding factor 2|nuclear factor of activated T-cells, 45-kDa; interleukin enhancer binding factor 2, 45kDa
    Gene Ontology: [View List]
    Co-purification
    hit Ting NS (1998)
    Affinity Capture-Western
    bait Ting NS (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ILF3
  • DRBF
  • DRBP76
  • MMP4
  • EG3609
    		•  The BioGRID Database Seperator M-phase phosphoprotein 4|double-stranded RNA-binding protein, 76 kD|dsRNA binding protein NFAR-2/MPP4|interleukin enhancer binding factor 3|nuclear factor associated with dsRNA|nuclear factor of activated T-cells, 90 kD|translational control protein 80; interleukin enhancer binding factor 3, 90kDa
    Gene Ontology: [View List]
    Co-purification
    hit Ting NS (1998)
    Affinity Capture-Western
    bait Ting NS (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHEK1
  • CHK1
  • EG1111
    		•  The BioGRID Database Seperator CHK1 checkpoint homolog|Checkpoint, S. pombe, homolog of, 1; CHK1 checkpoint homolog (S. pombe)
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    Reconstituted Complex
    bait Goudelock DM (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIB1
  • CIB
  • KIP
  • SIP2-28
  • EG10519
    		•  The BioGRID Database Seperator DNA-dependent protein kinase interacting protein|Snk interacting protein 2-28|calcium and integrin binding 1|calcium and integrin binding protein|calcium and integrin binding, protein kinase interacting protein|calmyrin; calcium and integrin binding 1 (calmyrin)
    Gene Ontology: [View List]
    Invitro
    hit Wu X (1997)
    Two-hybrid
    hit Wu X (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATM
  • AT1
  • ATA
  • ATC
  • EG472
    		•  The BioGRID Database Seperator AT complementation group A|AT complementation group C|AT complementation group D|AT complementation group E|AT mutated|AT protein|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein...
    Gene Ontology: [View List]
    Invitro
    bait Suzuki K (1999)
    Protein-peptide
    bait/hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCOA6
  • AIB3
  • ASC2
  • KIAA0181
  • RP5-1181N...
    		•  The BioGRID Database Seperator activating signal cointegrator-2|amplified in breast cancer-3 protein|nuclear receptor coactivator RAP250|peroxisome proliferator-activated receptor interacting protein|thyroid hormone receptor binding protein; nuclear receptor coactivator 6
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ko L (2000)
    Biochemical Activity
    hit Ko L (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IKBKB
  • IKK-beta
  • IKK2
  • IKKB
  • EG3551
    		•  The BioGRID Database Seperator inhibitor of nuclear factor kappa B kinase beta subunit|nuclear factor NF-kappa-B inhibitor kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    Gene Ontology: [View List]
    Biochemical Activity
    hit Liu L (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKT2
  • PKBBETA
  • PRKBB
  • RAC-BETA
  • EG208
    		•  The BioGRID Database Seperator Murine thymoma viral (v-akt) homolog-2|rac protein kinase beta; v-akt murine thymoma viral oncogene homolog 2
    Gene Ontology: [View List]
    Biochemical Activity
    hit Hresko RC (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LYN
  • JTK8
  • FLJ26625
  • EG4067
    		•  The BioGRID Database Seperator Yamaguchi sarcoma viral (v-yes-1) oncogene homolog|Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Kumar S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCF1
  • NCF1A
  • NOXO2
  • SH3PXD1A
  • EG653361
    		•  The BioGRID Database Seperator NADPH oxidase organizer 2|neutrophil cytosolic factor 1|neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1); neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Grandvaux N (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPK8
  • JNK
  • JNK1
  • JNK1A2
  • EG5599
    		•  The BioGRID Database Seperator JNK1 alpha protein kinase|JNK1 beta protein kinase|c-Jun N-terminal kinase 1|protein kinase JNK1|stress-activated protein kinase JNK1; mitogen-activated protein kinase 8
    Gene Ontology: [View List]
    Biochemical Activity
    hit Park SJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPK9
  • JNK-55
  • JNK2
  • JNK2A
  • EG5601
    		•  The BioGRID Database Seperator Jun kinase|MAP kinase 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase JNK2; mitogen-activated protein kinase 9
    Gene Ontology: [View List]
    Biochemical Activity
    hit Park SJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCF4
  • MGC3810
  • NCF
  • P40PHOX
  • CTA-833B7.1
    		•  The BioGRID Database Seperator OTTHUMP00000028736|OTTHUMP00000043756|neutrophil NADPH oxidase factor 4|neutrophil cytosol factor 4|neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa
    Gene Ontology: [View List]
    Biochemical Activity
    hit Grandvaux N (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCF2
  • NOXA2
  • P67-PHOX
  • p67phox
  • RP1-127C7.5
    		•  The BioGRID Database Seperator NADPH oxidase activator 2|neutrophil cytosolic factor 2|neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Grandvaux N (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABL1
  • ABL
  • JTK7
  • c-ABL
  • RP11-83J2...
    		•  The BioGRID Database Seperator Abelson murine leukemia viral (v-abl) oncogene homolog 1|BCR/ABL fusion protein|bcr/c-abl oncogene protein|proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Jin S (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EIF2S2
  • EIF2
  • EIF2B
  • EIF2beta
  • EG8894
    		•  The BioGRID Database Seperator eukaryotic initiation factor 2-beta|eukaryotic translation initiation factor 2 beta|eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
    Gene Ontology: [View List]
    Co-purification
    hit Ting NS (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RBBP8
  • CTIP
  • RIM
  • EG5932
    		•  The BioGRID Database Seperator CTBP-interacting protein|retinoblastoma-binding protein 8|retinoblastoma-interacting myosin-like; retinoblastoma binding protein 8
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AP1B1
  • ADTB1
  • AP105A
  • BAM22
  • EG162
    		•  The BioGRID Database Seperator Golgi adaptor HA1/AP1 adaptin beta subunit|adaptor protein complex AP-1 beta 1 subunit|adaptor-related protein complex 1 beta 1 subunit|beta-adaptin 1|beta-prime-adaptin|clathrin assembly protein complex 1 beta large chain|plasma membrane adaptor HA2/AP2 adaptor beta subunit; adaptor-related...
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRCA1
  • BRCAI
  • IRIS
  • PSCP
  • EG672
    		•  The BioGRID Database Seperator BRCA1/BRCA2-containing complex, subunit 1|breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AR
  • AIS
  • DHTR
  • HUMARA
  • RP11-383C...
    		•  The BioGRID Database Seperator androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); OTTHUMP00000061928|androgen receptor|dihydrotestosterone receptor
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Mayeur GL (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCLRE1C
  • DCLREC1C
  • FLJ11360
  • RS-SCID
  • RP11-398C...
    		•  The BioGRID Database Seperator OTTHUMP00000045150|artemis protein|severe combined immunodeficiency, type a (Athabascan); DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)
    Gene Ontology: [View List]
    Invitro
    bait Ma Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCNA
  • MGC8367
  • EG5111
    		•  The BioGRID Database Seperator DNA polymerase delta auxiliary protein|cyclin; proliferating cell nuclear antigen
    Gene Ontology: [View List]
    Invitro
    hit Ohta S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     E4F1
  • E4F
  • MGC99614
  • EG1877
    		•  The BioGRID Database Seperator E4F transcription factor 1; p120E4F
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LIG4
  • EG3981
    		•  The BioGRID Database Seperator DNA joinase|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase; ligase IV, DNA, ATP-dependent
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSF1
  • HSTF1
  • EG3297
    		•  The BioGRID Database Seperator heat shock transcription factor 1
    Gene Ontology: [View List]
    Invitro
    hit Huang J (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN5L2
  • GCN5
  • hGCN5
  • MGC102791
  • EG2648
    		•  The BioGRID Database Seperator GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2|GCN5 general control of amino-acid synthesis 5-like 2|General control of amino acid synthesis, yeast, homolog-like 2; GCN5 general control of amino-acid synthesis 5-like 2 (yeast)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Barlev NA (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD17
  • CCYC
  • HRAD17
  • R24L
  • EG5884
    		•  The BioGRID Database Seperator RAD1 (S. pombe) homolog|RAD17 homolog|RF-C activator 1 homolog|Rad17-like protein|cell cycle checkpoint protein (RAD17); RAD17 homolog (S. pombe)
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTS
  • PTPS
  • EG5805
    		•  The BioGRID Database Seperator 6-pyruvoyl-tetrahydropterin synthase|PTP synthase; 6-pyruvoyltetrahydropterin synthase
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11A
  • ATLD
  • HNGS1
  • MRE11
  • EG4361
    		•  The BioGRID Database Seperator AT-like disease|DNA recombination and repair protein|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination (S. cerevisiae) 11 homolog A|meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
    Gene Ontology: [View List]
    Protein-peptide
    hit Kim ST (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA1
  • HSSB
  • REPA1
  • RF-A
  • EG6117
    		•  The BioGRID Database Seperator replication protein A1, 70kDa; replication protein A1 (70kD)
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Shao RG (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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