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[JPG]
[PNG]
[SVG]
PF4
Homo sapiens
Aliases:
MGC138298, CXCL4, SCYB4
Description:
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
Links:
[UniprotKB]
|
[OMIM]
|
[HPRD]
|
[Entrez Gene]
Gene Ontology:
17 total GO annotations for this record.
[view list]
Function
Process
Component
•
chemokine activity
(
TAS
)
•
heparin binding
(
IDA
)
•
positive regulation of ge ...
(
IDA
)
•
positive regulation of fo ...
(
IDA
)
•
negative regulation of ap ...
(
IDA
)
•
leukocyte chemotaxis
(
IDA
)
•
positive regulation of tu ...
(
IDA
)
•
negative regulation of an ...
(
IDA
)
•
platelet activation
(
IDA
)
•
negative regulation of cy ...
(
IDA
)
•
cytokine-mediated signali ...
(
IDA
)
•
negative regulation of me ...
(
IDA
)
•
negative regulation of MH ...
(
IDA
)
•
extracellular region
(
IC
)
•
extracellular region
(
NAS
)
•
extracellular region
(
EXP
)
•
platelet alpha granule lu ...
(
EXP
)
Download interactions associated with PF4
PF4 was identified with
9
protein interactions
Name
Aliases
Description
Evidence Code
Role
Source [Interactions]
PF4
MGC138298
CXCL4
SCYB4
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
Gene Ontology:
[View List]
Co-crystal Structure
hit
Zhang X (1994)
[
1
]
hit
Mayo KH (1995)
[
1
]
Reconstituted Complex
hit
Barker S (1995)
[
1
]
CXCL12
TPAR1
SDF1A
PBSF
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
Gene Ontology:
[View List]
Reconstituted Complex
hit
Salcedo R (1999)
[
1
]
VCAN
PG-M
WGN1
WGN
chondroitin sulfate proteoglycan 2
Gene Ontology:
[View List]
Reconstituted Complex
bait
Hirose J (2001)
[
8
]
LDLR
LDLCQ2
FH
FHC
low-density lipoprotein receptor class A domain-containing protein 3
Gene Ontology:
[View List]
Reconstituted Complex
hit
Sachais BS (2002)
[
1
]
CXCR3
CMKAR3
CD182
MigR
chemokine (C-X-C motif) receptor 3
Gene Ontology:
[View List]
Reconstituted Complex
bait
Lasagni L (2003)
[
4
]
PROC
PROC1
PC
protein C (inactivator of coagulation factors Va and VIIIa)
Gene Ontology:
[View List]
Reconstituted Complex
hit
Dudek AZ (1997)
[
2
]
THBD
THRM
TM
CD141
thrombomodulin
Gene Ontology:
[View List]
Reconstituted Complex
hit
Dudek AZ (1997)
[
2
]
Copyright © 2009,
Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.