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[JPG]
[PNG]
[SVG]
PDGFB
Homo sapiens
Aliases:
FLJ12858, SSV, c-sis, PDGF2, SIS
Description:
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Links:
[UniprotKB]
|
[UniprotKB]
|
[UniprotKB]
|
[OMIM]
|
[HPRD]
|
[Entrez Gene]
Gene Ontology:
22 total GO annotations for this record.
[view list]
Function
Process
Component
•
protein heterodimerizatio ...
(
IPI
)
•
cell surface binding
(
IDA
)
•
platelet-derived growth f ...
(
IPI
)
•
platelet-derived growth f ...
(
NAS
)
•
collagen binding
(
IDA
)
•
protein homodimerization ...
(
IDA
)
•
platelet-derived growth f ...
(
IDA
)
•
monocyte chemotaxis
(
IDA
)
•
positive regulation of fi ...
(
IDA
)
•
positive regulation of sm ...
(
IDA
)
•
positive regulation of MA ...
(
IDA
)
•
negative regulation of pl ...
(
IDA
)
•
positive regulation of bl ...
(
IDA
)
•
positive regulation of ch ...
(
IDA
)
•
positive regulation of DN ...
(
IDA
)
•
cell chemotaxis
(
IDA
)
•
negative regulation of ph ...
(
IDA
)
•
response to wounding
(
NAS
)
•
cell surface
(
IDA
)
•
platelet dense granule lu ...
(
EXP
)
•
extracellular region
(
NAS
)
•
extracellular region
(
EXP
)
Download interactions associated with PDGFB
PDGFB was identified with
7
protein interactions
Name
Aliases
Description
Evidence Code
Role
Source [Interactions]
PDGFB
FLJ12858
SSV
c-sis
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Gene Ontology:
[View List]
Co-crystal Structure
hit
Oefner C (1992)
[
1
]
HSPG2
SJS1
PLC
PRCAN
RP11-132G...
Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia)
Gene Ontology:
[View List]
Reconstituted Complex
bait
Goehring W (1998)
[
2
]
THBS1
THBS
TSP1
THBS-1
thrombospondin-1p180
Gene Ontology:
[View List]
Reconstituted Complex
bait
Hogg PJ (1997)
[
1
]
PDAP1
PAP1
HASPP28
PAP
PDGFA associated protein 1
Gene Ontology:
[View List]
Co-purification
bait
Fischer WH (1996)
[
2
]
LRP1
A2MR
LRP
APR
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
Gene Ontology:
[View List]
Reconstituted Complex
bait
Loukinova E (2002)
[
3
]
SPARC
ON
secreted protein, acidic, cysteine-rich (osteonectin)
Gene Ontology:
[View List]
Reconstituted Complex
bait
Raines EW (1992)
[
1
]
PDGFRA
CD140A
PDGFR2
RHEPDGFRA
rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
Gene Ontology:
[View List]
Reconstituted Complex
bait
Claesson-Welsh L (1989)
[
2
]
Copyright © 2009,
Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.