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BioGRID | Network Layout for MDM2 for Homo sapiens
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MDM2

 Homo sapiens
The BioGRID Database Seperator
Aliases: MGC71221, hdm2, HDMX, EG4193
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: double minute 2, human homolog of; p53-binding protein|mouse double minute 2 homolog|p53-binding protein MDM2|ubiquitin-protein ligase E3 Mdm2; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 12 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with MDM2

MDM2 was identified with 88 protein interactions and 1 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 TP53
  • TRP53
  • p53
  • LFS1
  • EG7157
    		•  The BioGRID Database Seperator tumor protein p53 (Li-Fraumeni syndrome); p53 tumor suppressor|tumor protein p53
    Gene Ontology: [View List]
    Invivo
    bait Latonen L (2001)
    bait Chen J (1993)
    bait Picksley SM (1994)
    bait Momand J (2000)
    Biochemical Activity
    hit Li M (2003)
    bait/hit Fang S (2000)
    Affinity Capture-Western
    hit Latonen L (2001)
    bait/hit Zhang Y (2003)
    bait Kurki S (2003)
    bait Freeman DJ (2003)
    bait Ito A (2002)
    bait/hit Zhang Y (1998)
    Reconstituted Complex
    bait Kurki S (2003)
    bait Ito A (2002)
    bait Liu G (2000)
    Co-fractionation
    hit Grossman SR (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDKN2A
  • ARF
  • CDK4I
  • CDKN2
  • EG1029
    		•  The BioGRID Database Seperator CDK4 inhibitor p16-INK4|cell cycle negative regulator beta|cyclin-dependent kinase inhibitor 2A|cyclin-dependent kinase inhibitor p16|multiple tumor suppressor 1; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
    Gene Ontology: [View List]
    Invivo
    bait Clark PA (2002)
    bait Pomerantz J (1998)
    Invitro
    bait Clark PA (2002)
    bait Pomerantz J (1998)
    Affinity Capture-MS
    hit Zhang Y (2003)
    Affinity Capture-Western
    bait/hit Zhang Y (2003)
    bait/hit Zhang Y (1998)
    Two-hybrid
    bait Zhang Y (1998)
    Reconstituted Complex
    bait/hit Zhang Y (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PML
  • MYL
  • PP8675
  • RNF71
  • EG5371
    		•  The BioGRID Database Seperator promyelocytic leukemia protein|promyelocytic leukemia, inducer of|tripartite motif protein TRIM19; promyelocytic leukemia
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bernardi R (2004)
    bait Zhu H (2003)
    hit Kurki S (2003)
    bait Wei X (2003)
    Reconstituted Complex
    bait Bernardi R (2004)
    bait Zhu H (2003)
    hit Kurki S (2003)
    bait Wei X (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM4
  • DKFZp781B...
  • MDMX
  • MRP1
  • RP11-430C...
    		•  The BioGRID Database Seperator MDM4-related protein 1|double minute 4, human homolog of; p53-binding protein|mouse double minute 4 homolog|p53-binding protein; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
    Gene Ontology: [View List]
    Invivo
    bait Tanimura S (1999)
    bait Badciong JC (2002)
    Invitro
    bait Tanimura S (1999)
    bait Badciong JC (2002)
    Two-hybrid
    bait Tanimura S (1999)
    bait Badciong JC (2002)
    Reconstituted Complex
    bait Kadakia M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TP73
  • P73
  • EG7161
    		•  The BioGRID Database Seperator p53-related protein; tumor protein p73
    Gene Ontology: [View List]
    Invivo
    hit Zeng X (1999)
    Invitro
    hit Zeng X (1999)
    Reconstituted Complex
    hit alint E (1999)
    Affinity Capture-Western
    hit alint E (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIF1A
  • HIF-1alpha
  • HIF1-ALPHA
  • MOP1
  • EG3091
    		•  The BioGRID Database Seperator ARNT interacting protein|hypoxia-inducible factor 1, alpha subunit|member of PAS superfamily 1; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    Gene Ontology: [View List]
    Invitro
    bait Ravi R (2000)
    Reconstituted Complex
    hit Chen D (2003)
    Affinity Capture-Western
    bait Chen D (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RB1
  • OSRC
  • RB
  • EG5925
    		•  The BioGRID Database Seperator retinoblastoma 1|retinoblastoma susceptibility protein|retinoblastoma suspectibility protein|retinoblastoma-1; retinoblastoma 1 (including osteosarcoma)
    Gene Ontology: [View List]
    Invitro
    bait Hsieh JK (1999)
    bait Momand J (2000)
    bait Xiao ZX (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EP300
  • p300
  • KAT3B
  • RP1-85F18.1
    		•  The BioGRID Database Seperator E1A-associated protein p300|E1A-binding protein, 300kD|OTTHUMP00000028668; E1A binding protein p300
    Gene Ontology: [View List]
    Reconstituted Complex
    bait/hit Grossman SR (1998)
    Affinity Capture-Western
    hit Grossman SR (1998)
    Co-fractionation
    bait Grossman SR (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABL1
  • ABL
  • JTK7
  • c-ABL
  • RP11-83J2...
    		•  The BioGRID Database Seperator Abelson murine leukemia viral (v-abl) oncogene homolog 1|BCR/ABL fusion protein|bcr/c-abl oncogene protein|proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Goldberg Z (2002)
    Reconstituted Complex
    hit Goldberg Z (2002)
    Biochemical Activity
    bait Goldberg Z (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCAF
  • CAF
  • P/CAF
  • P
  • EG8850
    		•  The BioGRID Database Seperator p300/CBP-associated factor; CREBBP-associated factor
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Jin Y (2002)
    Affinity Capture-Western
    bait Jin Y (2002)
    Phenotypic Suppression
    bait Jin Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL11
  • GIG34
  • EG6135
    		•  The BioGRID Database Seperator 60S ribosomal protein L11|CLL-associated antigen KW-12|cell growth-inhibiting protein 34; ribosomal protein L11
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Zhang Y (2003)
    Affinity Capture-Western
    bait/hit Zhang Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUMB
  • S171
  • EG8650
    		•  The BioGRID Database Seperator numb homolog (Drosophila); numb homolog
    Gene Ontology: [View List]
    Reconstituted Complex
    bait/hit Yogosawa S (2003)
    Biochemical Activity
    hit Yogosawa S (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HDAC1
  • HD1
  • RPD3
  • RPD3L1
  • EG3065
    		•  The BioGRID Database Seperator reduced potassium dependency, yeast homolog-like 1; histone deacetylase 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Ito A (2002)
    Reconstituted Complex
    hit Ito A (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCNG1
  • CCNG
  • EG900
    		•  The BioGRID Database Seperator cyclin G1
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Zhao L (2003)
    Affinity Capture-Western
    hit Zhao L (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTATIP
  • HTATIP1
  • PLIP
  • TIP
  • EG10524
    		•  The BioGRID Database Seperator HIV-1 Tat interactive protein, 60kDa|Tat interactive protein (60kD)|cPLA2 interacting protein; HIV-1 Tat interacting protein, 60kDa
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Legube G (2002)
    Reconstituted Complex
    hit Legube G (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTBP2
  • EG1488
    		•  The BioGRID Database Seperator C-terminal binding protein 2; ribeye
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Mirnezami AH (2003)
    Affinity Capture-Western
    bait Mirnezami AH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARRB2
  • ARB2
  • ARR2
  • DKFZp686L...
  • EG409
    		•  The BioGRID Database Seperator arrestin, beta 2
    Gene Ontology: [View List]
    Invivo
    hit Wang P (2003)
    Affinity Capture-Western
    bait/hit Wang P (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL5
  • MSTP030
  • MGC117339
  • EG6125
    		•  The BioGRID Database Seperator 60S ribosomal protein L5; ribosomal protein L5
    Gene Ontology: [View List]
    Invivo
    bait Marechal V (1994)
    Affinity Capture-MS
    hit Zhang Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTBP
  • MDM2BP
  • EG27085
    		•  The BioGRID Database Seperator MDM2 (mouse double minute 2)-binding protein, 104kD|Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
    Gene Ontology: [View List]
    Invitro
    bait/hit Boyd MT (2000)
    Two-hybrid
    hit Boyd MT (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTBP1
  • MGC104684
  • BARS
  • EG1487
    		•  The BioGRID Database Seperator brefeldin A-ribosylated substrate; C-terminal binding protein 1
    Gene Ontology: [View List]
    Far Western
    hit Mirnezami AH (2003)
    Affinity Capture-Western
    hit Mirnezami AH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESR1
  • DKFZp686N...
  • ER
  • ESR
  • RP1-130E4.1
    		•  The BioGRID Database Seperator dJ443C4.1.1 (estrogen receptor 1)|estrogen receptor 1 (alpha)|oestrogen receptor|steroid hormone receptor; estrogen receptor 1
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Liu G (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM2
  • MGC71221
  • hdm2
  • HDMX
  • EG4193
    		•  The BioGRID Database Seperator double minute 2, human homolog of; p53-binding protein|mouse double minute 2 homolog|p53-binding protein MDM2|ubiquitin-protein ligase E3 Mdm2; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
    Gene Ontology: [View List]
    Biochemical Activity
    bait/hit Fang S (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTF2E2
  • FE
  • TF2E2
  • TFIIE-B
  • EG2961
    		•  The BioGRID Database Seperator general transcription factor IIE, polypeptide 2 (beta subunit, 34kD); general transcription factor IIE, polypeptide 2, beta 34kDa
    Gene Ontology: [View List]
    Invitro
    bait Thut CJ (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSG101
  • TSG10
  • VPS23
  • EG7251
    		•  The BioGRID Database Seperator tumor susceptibility gene 101; tumor susceptibility protein
    Gene Ontology: [View List]
    Invivo
    hit Li L (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF1
  • BA2R
  • CCG1
  • CCGS
  • EG6872
    		•  The BioGRID Database Seperator TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD|TBP-associated factor 1|cell cycle, G1 phase defect|complementation of cell cycle block, G1-to-S|dystonia 3 (with Parkinsonism)|transcription factor TFIID p250 polypeptide; TAF1 RNA polymerase II, TATA box binding...
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Leveillard T (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TBP
  • GTF2D
  • GTF2D1
  • SCA17
  • EG6908
    		•  The BioGRID Database Seperator TATA box binding protein
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Leveillard T (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBE2A
  • HHR6A
  • RAD6A
  • UBC2
  • EG7319
    		•  The BioGRID Database Seperator ubiquitin carrier protein A|ubiquitin-conjugating enzyme E2A|ubiquitin-protein ligase A; ubiquitin-conjugating enzyme E2A (RAD6 homolog)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lyakhovich A (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRI1
  • C15orf3
  • EID-1
  • EID1
  • EG23741
    		•  The BioGRID Database Seperator CREBBP/EP300 inhibitor 1|CREBBP/EP300 inhibitory protein 1|NB4 apoptosis related protein|Rb- and p300-binding protein EID-1|retinoblastoma protein-associated protein; EP300 interacting inhibitor of differentiation 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Miyake S (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUMO1
  • GMP1
  • PIC1
  • SENP2
  • EG7341
    		•  The BioGRID Database Seperator GAP modifying protein 1|SMT3 suppressor of mif two 3 homolog 1|sentrin|ubiquitin-like 1 (sentrin); SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
    Gene Ontology: [View List]
    Invitro
    bait Buschmann T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDC1
  • KIAA0170
  • NFBD1
  • DKFZp781A...
  • DAQB-47P1...
    		•  The BioGRID Database Seperator homologue to Drosophila photoreceptor protein calphotin|nuclear factor with BRCT domains 1; mediator of DNA damage checkpoint 1
    Gene Ontology: [View List]
    Protein-peptide
    bait Rodriguez M (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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