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BioGRID | Network Layout for SMAD4 for Homo sapiens
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SMAD4

 Homo sapiens
The BioGRID Database Seperator
Aliases: DPC4, JIP, MADH4, EG4089
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: MAD (mothers against decapentaplegic, Drosophila) homolog 4|MAD, mothers against decapentaplegic homolog 4|Mothers against decapentaplegic, Drosophila, homolog of, 4|SMAD, mothers against DPP homolog 4|deleted in pancreatic carcinoma locus 4|mothers against decapentaplegic homolog 4; SMAD family member 4
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 12 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SMAD4

SMAD4 was identified with 128 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SMAD2
  • JV18
  • JV18-1
  • MADH2
  • EG4087
    		•  The BioGRID Database Seperator MAD, mothers against decapentaplegic homolog 2|Mad protein homolog|Mad, mothers against decapentaplegic homolog 2|Mad-related protein 2|SMAD, mothers against DPP homolog 2|Sma- and Mad-related protein 2|mother against DPP homolog 2; SMAD family member 2
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Moren A (2003)
    bait Wotton D (1999)
    bait Mori N (2001)
    bait Wu JW (2002)
    bait Nakao A (1997)
    hit Wicks SJ (2000)
    Reconstituted Complex
    bait Wu JW (2002)
    bait Wu JW (2001)
    Two-hybrid
    hit Chen X (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKI
  • SKV
  • EG6497
    		•  The BioGRID Database Seperator Avian sarcoma viral (v-ski) oncogene homolog|ski oncoprotein|v-ski avian sarcoma viral oncogene homolog|v-ski sarcoma viral oncogene homolog; v-ski sarcoma viral oncogene homolog (avian)
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Harada J (2003)
    Affinity Capture-Western
    bait Ueki N (2003)
    Co-crystal Structure
    bait Wu JW (2002)
    Affinity Capture-MS
    hit Stroschein SL (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMAD3
  • DKFZP586N...
  • DKFZp686J...
  • HSPC193
  • EG4088
    		•  The BioGRID Database Seperator MAD, mothers against decapentaplegic homolog 3|SMA- and MAD-related protein 3|SMAD, mothers against DPP homolog 3|mad homolog JV15-2|mad protein homolog|mothers against decapentaplegic homolog 3; SMAD family member 3
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Seoane J (2004)
    hit Moren A (2003)
    bait Wu JW (2002)
    bait Nakao A (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMAD1
  • BSP1
  • JV4-1
  • JV41
  • EG4086
    		•  The BioGRID Database Seperator MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|Sma- and Mad-related protein 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|transforming growth factor-beta signaling protein 1; SMAD family member 1
    Gene Ontology: [View List]
    Invitro
    bait Lopez-Rovira T (2002)
    Invivo
    bait Lopez-Rovira T (2002)
    Affinity Capture-Western
    bait Harada J (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATF2
  • CRE-BP1
  • CREB2
  • HB16
  • EG1386
    		•  The BioGRID Database Seperator activating transcription factor 2 splice variant ATF2-var2|cAMP responsive element binding protein 2, formerly; activating transcription factor 2
    Gene Ontology: [View List]
    Two-hybrid
    bait Sano Y (1999)
    Reconstituted Complex
    hit Sano Y (1999)
    Affinity Capture-Western
    bait Sano Y (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCP1A
  • HSA275986
  • SMAD4IP1
  • SMIF
  • EG55802
    		•  The BioGRID Database Seperator DCP1 decapping enzyme homolog A|Smad4-interacting transcriptional co-activator|decapping enzyme hDcp1a|putative protein product of Nbla00360|transcription factor SMIF; DCP1 decapping enzyme homolog A (S. cerevisiae)
    Gene Ontology: [View List]
    Two-hybrid
    bait Bai RY (2002)
    Affinity Capture-Western
    hit Bai RY (2002)
    Reconstituted Complex
    hit Bai RY (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COPS5
  • JAB1
  • MGC3149
  • MOV-34
  • EG10987
    		•  The BioGRID Database Seperator 38 kDa Mov34 homolog|COP9 signalosome subunit 5|Jun activation domain-binding protein; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
    Gene Ontology: [View List]
    Invivo
    hit Wan M (2002)
    Invitro
    hit Wan M (2002)
    Two-hybrid
    hit Wan M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZNF8
  • HF.18
  • Zfp128
  • EG7554
    		•  The BioGRID Database Seperator zinc finger protein 272|zinc finger protein 8 (clone HF.18); zinc finger protein 8
    Gene Ontology: [View List]
    Invitro
    bait Jiao K (2002)
    Invivo
    bait Jiao K (2002)
    Two-hybrid
    bait Jiao K (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMAD9
  • MADH6
  • MADH9
  • SMAD8A
  • EG4093
    		•  The BioGRID Database Seperator MAD (mothers against decapentaplegic, Drosophila) homolog 9|MAD, mothers against decapentaplegic homolog 9|Mothers against decapentaplegic, drosophila, homolog of, 9|SMAD, mothers against DPP homolog 9; SMAD family member 9
    Gene Ontology: [View List]
    Two-hybrid
    hit Rual JF (2005)
    Affinity Capture-Western
    bait/hit Nishita M (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BTRC
  • BETA-TRCP
  • FBW1A
  • FBXW1A
  • RP11-529I...
    		•  The BioGRID Database Seperator beta-TrCP1|beta-transducin repeat containing protein; beta-transducin repeat containing
    Gene Ontology: [View List]
    Two-hybrid
    bait Wan M (2004)
    Affinity Capture-Western
    hit Wan M (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIAS3
  • FLJ14651
  • ZMIZ5
  • EG10401
    		•  The BioGRID Database Seperator protein inhibitor of activated STAT3|zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT, 3
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Long J (2004)
    Reconstituted Complex
    hit Long J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGFBRAP1
  • TRAP-1
  • TRAP1
  • EG9392
    		•  The BioGRID Database Seperator transforming growth factor, beta receptor associated protein 1; TGF beta receptor associated protein -1
    Gene Ontology: [View List]
    Invivo
    hit Wurthner JU (2001)
    Invitro
    hit Wurthner JU (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LEF1
  • DKFZp586H...
  • TCF1ALPHA
  • EG51176
    		•  The BioGRID Database Seperator lymphoid enhancer-binding factor 1; lymphoid enhancer binding factor-1
    Gene Ontology: [View List]
    Invivo
    hit Labbe E (2000)
    Invitro
    hit Labbe E (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFE3
  • RCCP2
  • TFEA
  • EG7030
    		•  The BioGRID Database Seperator Renal cell carcinoma, papillary|Transcription factor for IgH enhancer|transcription factor E family, member A|transcription factor E3; transcription factor binding to IGHM enhancer 3
    Gene Ontology: [View List]
    Invitro
    bait Hua X (1999)
    Reconstituted Complex
    hit Grinberg AV (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKIL
  • SNO
  • SnoA
  • SnoN
  • EG6498
    		•  The BioGRID Database Seperator SKI-like|ski-related oncogene snoN; SKI-like oncogene
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Stroschein SL (1999)
    Affinity Capture-Western
    hit Stroschein SL (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FOXH1
  • FAST-1
  • FAST1
  • EG8928
    		•  The BioGRID Database Seperator Human homolog of Xenopus forkhead activin signal transducer-1; forkhead box H1
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Chen X (1997)
    Two-hybrid
    bait Chen X (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEBPB
  • C/EBP-beta
  • CRP2
  • IL6DBP
  • EG1051
    		•  The BioGRID Database Seperator CCAAT/enhancer binding protein beta|interleukin 6-dependent DNA-binding protein|liver-enriched transcriptional activator protein|nuclear factor of interleukin 6|transcription factor 5; CCAAT/enhancer binding protein (C/EBP), beta
    Gene Ontology: [View List]
    Invitro
    bait Choy L (2003)
    Invivo
    bait Choy L (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CITED1
  • MSG1
  • EG4435
    		•  The BioGRID Database Seperator Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
    Gene Ontology: [View List]
    Invitro
    bait Shioda T (1998)
    Two-hybrid
    bait Shioda T (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AR
  • AIS
  • DHTR
  • HUMARA
  • RP11-383C...
    		•  The BioGRID Database Seperator androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); OTTHUMP00000061928|androgen receptor|dihydrotestosterone receptor
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Kang HY (2002)
    Reconstituted Complex
    bait/hit Kang HY (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FOXO1A
  • FKH1
  • FKHR
  • FOXO1
  • EG2308
    		•  The BioGRID Database Seperator forkhead box O1A (rhabdomyosarcoma)|forkhead homolog in rhabdomyosarcoma|forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead box O1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seoane J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FOXO3A
  • AF6q21
  • DKFZp781A...
  • FKHRL1
  • EG2309
    		•  The BioGRID Database Seperator forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1|forkhead box O3A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; forkhead box O3
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seoane J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Rab34
  • Rah
  • Rah1
  • AI326479
  • RP23-185A...
    		•  The BioGRID Database Seperator RAB34, member of RAS oncogene family
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBE2I
  • C358B7.1
  • P18
  • UBC9
  • EG7329
    		•  The BioGRID Database Seperator SUMO-1-protein ligase|ubiquitin carrier protein|ubiquitin conjugating enzyme 9|ubiquitin-conjugating enzyme E2I|ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)|ubiquitin-conjugating enzyme UbcE2A|ubiquitin-like protein SUMO-1 conjugating enzyme|ubiquitin-protein ligas...
    Gene Ontology: [View List]
    Two-hybrid
    hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLLT7
  • AFX
  • AFX1
  • FOXO4
  • EG4303
    		•  The BioGRID Database Seperator myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 7|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; forkhead box O4
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seoane J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Apbb2
  • 2310007D0...
  • Rirl1
  • TR2L
  • EG11787
    		•  The BioGRID Database Seperator amyloid beta (A4) precursor protein-binding, family B, member 2; zinc finger-like protein
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Rps27a
  • 0610006J1...
  • RP23-92B1...
    		•  The BioGRID Database Seperator ribosomal protein S27a
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Itk
  • Emt
  • Tcsk
  • Tsk
  • RP23-273O...
    		•  The BioGRID Database Seperator interleukin-2-inducible T cell kinase; IL2-inducible T-cell kinase
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Ap2b1
  • 1300012O0...
  • AI788979
  • RP23-381B...
    		•  The BioGRID Database Seperator adaptor-related protein complex 2, beta 1 subunit
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Rtdr1
  • 4933431K0...
  • EG71236
    		•  The BioGRID Database Seperator rhabdoid tumor deletion region gene 1
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Ubb
  • Ubb2
  • AL033289
  • RP23-234K...
    		•  The BioGRID Database Seperator ubiquitin B
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Smad2
  • Madh2
  • Madr2
  • EG17126
    		•  The BioGRID Database Seperator MAD homolog 2 (Drosophila); MAD homolog 2|Smad 2
    Gene Ontology: [View List]
    Affinity Capture-Luminescence
    hit Barrios-Rodiles M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EWSR1
  • EWS
  • EG2130
    		•  The BioGRID Database Seperator Ewings sarcoma EWS-Fli1 (type 1) oncogene|bK984G1.4 (Ewing sarcoma breakpoint region 1 protein)|extraskeletal myxoid chondrosarcoma EWS/TEC/CHN fusion protein; Ewing sarcoma breakpoint region 1
    Gene Ontology: [View List]
    Two-hybrid
    bait Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERBB2IP
  • ERBIN
  • LAP2
  • EG55914
    		•  The BioGRID Database Seperator ERBB2 interacting protein|ERBB2-interacting protein|densin-180-like protein; erbb2 interacting protein
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Warner DR (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KPNB1
  • IMB1
  • IPOB
  • Impnb
  • EG3837
    		•  The BioGRID Database Seperator importin 90|importin beta-1 subunit|karyopherin beta 1|nuclear factor p97; karyopherin (importin) beta 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Xiao Z (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOB1
  • APRO6
  • MGC34446
  • TOB
  • EG10140
    		•  The BioGRID Database Seperator transducer of ERBB2, 1; transducer of erbB-2
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Yoshida Y (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZNF423
  • Ebfaz
  • KIAA0760
  • OAZ
  • EG23090
    		•  The BioGRID Database Seperator OLF-1/EBF associated zinc finger|Smad- and Olf-interacting zinc finger protein|early B-cell factor associated zinc finger protein; zinc finger protein 423
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Hata A (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator