The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for LCK for Homo sapiens
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

LCK

 Homo sapiens
The BioGRID Database Seperator
Aliases: YT16, p56lck, pp58lck, EG3932
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: T-lymphocyte specific protein tyrosine kinase p56lck|p56(LSTRA) protein-tyrosine kinase|protein tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK; lymphocyte-specific protein tyrosine kinase
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 28 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with LCK

LCK was identified with 70 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 PTPN6
  • HCP
  • HCPH
  • HPTP1C
  • EG5777
    		•  The BioGRID Database Seperator 70 kda SHP-1L protein|hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C; protein tyrosine phosphatase, non-receptor type 6
    Gene Ontology: [View List]
    Invivo
    bait Lorenz U (1994)
    bait Chiang GG (2001)
    Invitro
    bait Lorenz U (1994)
    bait Chiang GG (2001)
    Biochemical Activity
    bait Yu CL (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIK3CA
  • PI3K
  • p110-alpha
  • MGC142161
  • EG5290
    		•  The BioGRID Database Seperator PI3-kinase p110 subunit alpha|PtdIns-3-kinase p110|phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha|phosphatidylinositol 3-kinase, catalytic, alpha polypeptide|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphoinositide-3-kinase, catalytic, alpha...
    Gene Ontology: [View List]
    Invitro
    bait von Willebrand M (1994)
    Affinity Capture-Western
    hit Sade H (2004)
    Reconstituted Complex
    hit Prasad KV (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SQSTM1
  • PDB3
  • ZIP3
  • p60
  • EG8878
    		•  The BioGRID Database Seperator Paget disease of bone 3|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|ubiquitin-binding protein p62; sequestosome 1
    Gene Ontology: [View List]
    Invivo
    bait Joung I (1996)
    Invitro
    bait Joung I (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CD4
  • CD4mut
  • EG920
    		•  The BioGRID Database Seperator CD4 antigen|CD4 antigen (p55)|CD4 receptor; CD4 molecule
    Gene Ontology: [View List]
    Invivo
    bait Foti M (2002)
    Affinity Capture-Western
    bait Hawash IY (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CBL
  • C-CBL
  • CBL2
  • RNF55
  • EG867
    		•  The BioGRID Database Seperator Cas-Br-M (murine) ecotropic retroviral transforming sequence; oncogene CBL2
    Gene Ontology: [View List]
    Invivo
    hit Husson H (1997)
    Affinity Capture-Western
    hit Rao N (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CD2
  • SRBC
  • T11
  • RP4-655N1...
    		•  The BioGRID Database Seperator CD2 antigen (p50), sheep red blood cell receptor|OTTHUMP00000059318|lymphocyte-function antigen-2; CD2 molecule
    Gene Ontology: [View List]
    Invivo
    bait Bell GM (1996)
    Invitro
    bait Bell GM (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB
  • rd5
  • EG7275
    		•  The BioGRID Database Seperator tubby homolog (mouse); tubby|tubby homologue
    Gene Ontology: [View List]
    Invivo
    bait Kapeller R (1999)
    Invitro
    bait Kapeller R (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NR2F2
  • ARP1
  • COUP-TFII
  • COUPTFB
  • EG7026
    		•  The BioGRID Database Seperator ADP-ribosylation factor related protein 1|transcription factor COUP 2 (chicken ovalbumin upstream promoter 2, apolipoprotein regulatory protein); nuclear receptor subfamily 2, group F, member 2
    Gene Ontology: [View List]
    Two-hybrid
    bait Marcus SL (1996)
    Reconstituted Complex
    bait Marcus SL (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADAM15
  • MDC15
  • EG8751
    		•  The BioGRID Database Seperator ADAM metallopeptidase domain 15 (metargidin)|a disintegrin and metalloproteinase domain 15|a disintegrin and metalloproteinase domain 15 (metargidin)|metalloprotease RGD disintegrin protein|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15|metargidin; ADAM metallopeptidase...
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Poghosyan Z (2002)
    Reconstituted Complex
    bait Poghosyan Z (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     Cd3e
  • CD3
  • CD3epsilon
  • T3e
  • EG12501
    		•  The BioGRID Database Seperator CD3 antigen, epsilon polypeptide
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Guirado M (2002)
    Affinity Capture-Western
    bait Guirado M (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBE3A
  • ANCR
  • AS
  • E6-AP
  • EG7337
    		•  The BioGRID Database Seperator CTCL tumor antigen se37-2|human papilloma virus E6-associated protein|oncogenic protein-associated protein E6-AP|ubiquitin protein ligase E3A; ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
    Gene Ontology: [View List]
    Two-hybrid
    bait Oda H (1999)
    Reconstituted Complex
    bait Oda H (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTPRC
  • B220
  • CD45
  • GP180
  • EG5788
    		•  The BioGRID Database Seperator CD45 antigen|SCID due to PTPRC deficiency|T200 glycoprotein|T200 leukocyte common antigen|glycoprotein|human homolog of severe combined immunodeficiency due to PTPRC deficiency|leukocyte-common antigen|protein tyrosine phosphatase, receptor type, c polypeptide; protein tyrosine phosphatase,...
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Koretzky GA (1993)
    Reconstituted Complex
    bait Ng DH (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRPV4
  • OTRPC4
  • TRP12
  • VRL-2
  • EG59341
    		•  The BioGRID Database Seperator OSM9-like transient receptor potential channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential channel 12|vanilloid receptor-related osmotically activated channel; transient receptor potential cation channel, subfamily V, member 4
    Gene Ontology: [View List]
    Invitro
    bait Xu H (2003)
    Invivo
    bait Xu H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UNC119
  • HRG4
  • EG9094
    		•  The BioGRID Database Seperator retinal protein 4|unc119 (C.elegans) homolog; unc-119 homolog (C. elegans)
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Gorska MM (2004)
    Reconstituted Complex
    bait Gorska MM (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTLA4
  • CD152
  • CTLA-4
  • CELIAC3
  • EG1493
    		•  The BioGRID Database Seperator cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; cytotoxic T-lymphocyte-associated protein 4
    Gene Ontology: [View List]
    Invivo
    bait Miyatake S (1998)
    Invitro
    bait Miyatake S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CD38
  • T10
  • EG952
    		•  The BioGRID Database Seperator ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase|CD38 antigen|CD38 antigen (p45)|cyclic ADP-ribose hydrolase; CD38 molecule
    Gene Ontology: [View List]
    Invivo
    bait Cho YS (2000)
    Invitro
    bait Cho YS (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DLG1
  • DKFZp761P...
  • DLGH1
  • SAP97
  • EG1739
    		•  The BioGRID Database Seperator discs large homolog 1|discs, large homolog 1|presynaptic protein SAP97|synapse-associated protein 97; discs, large homolog 1 (Drosophila)
    Gene Ontology: [View List]
    Invitro
    bait Hanada T (1997)
    Invivo
    bait Hanada T (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADAM10
  • HsT18717
  • MADM
  • kuz
  • EG102
    		•  The BioGRID Database Seperator a disintegrin and metalloprotease domain 10|a disintegrin and metalloproteinase domain 10|kuzbanian; ADAM metallopeptidase domain 10
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Poghosyan Z (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCAP1
  • SKAP55
  • SKAP1
  • EG8631
    		•  The BioGRID Database Seperator src family associated phosphoprotein 1|src kinase-associated phosphoprotein of 55 kDa; src kinase associated phosphoprotein 1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Marie-Cardine A (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIT
  • C-Kit
  • CD117
  • PBT
  • EG3815
    		•  The BioGRID Database Seperator mast/stem cell growth factor receptor|proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Krystal GW (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PXN
  • FLJ16691
  • hCG_1778014
    		•  The BioGRID Database Seperator paxillin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ostergaard HL (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCAR1
  • CAS
  • CRKAS
  • P130Cas
  • EG9564
    		•  The BioGRID Database Seperator breast cancer anti-estrogen resistance 1; Crk-associated substrate p130Cas
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Manie SN (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAS
  • ALPS1A
  • APO-1
  • APT1
  • EG355
    		•  The BioGRID Database Seperator APO-1 cell surface antigen|CD95 antigen|Fas antigen|OTTHUMP00000059646|apoptosis antigen 1|tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6)
    Gene Ontology: [View List]
    Invivo
    hit Schlottmann KE (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIK4CA
  • PI4K-ALPHA
  • pi4K230
  • FLJ16556
  • EG5297
    		•  The BioGRID Database Seperator phosphatidylinositol 4-kinase 230|phosphatidylinositol 4-kinase, catalytic, alpha polypeptide|phosphatidylinositol 4-kinase, type II, alpha|phosphatidylinositol 4-kinase, type III, alpha; phosphatidylinositol 4-kinase, catalytic, alpha
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Prasad KV (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LNK
  • SH2B3
  • EG10019
    		•  The BioGRID Database Seperator lymphocyte adaptor protein; SH2B adaptor protein 3
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Li Y (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRAT1
  • HSPC062
  • TCRIM
  • TRIM
  • EG50852
    		•  The BioGRID Database Seperator T cell receptor interacting molecule|T-cell receptor interacting molecule; T cell receptor associated transmembrane adaptor 1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Brdicka T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NEDD9
  • CAS-L
  • CASL
  • HEF1
  • EG4739
    		•  The BioGRID Database Seperator Crk-associated substrate related|cas-like docking|dJ49G10.2 (Enhancer of Filamentation 1 (HEF1))|dJ761I2.1 (enhancer of filamentation (HEF1))|enhancer of filamentation 1; neural precursor cell expressed, developmentally down-regulated 9
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Minegishi M (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAG1
  • CBP
  • FLJ37858
  • PAG
  • EG55824
    		•  The BioGRID Database Seperator Csk-binding protein|phosphoprotein associated with glycosphingolipid-enriched microdomains; phosphoprotein associated with glycosphingolipid microdomains 1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Brdicka T (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MS4A1
  • B1
  • Bp35
  • CD20
  • EG931
    		•  The BioGRID Database Seperator B-lymphocyte cell-surface antigen B1|CD20 antigen|CD20 receptor; membrane-spanning 4-domains, subfamily A, member 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Deans JP (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARHGAP17
  • DKFZp564A...
  • FLJ43368
  • MGC87805
  • EG55114
    		•  The BioGRID Database Seperator RICH1B protein|RhoGAP interacting with CIP4 homologs 1|nadrin|neuron-associated developmentally regulated protein; Rho GTPase activating protein 17
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Richnau N (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FASLG
  • APT1LG1
  • CD178
  • CD95L
  • EG356
    		•  The BioGRID Database Seperator CD95 ligand|apoptosis (APO-1) antigen ligand 1|fas ligand|tumor necrosis factor (ligand) superfamily, member 6; Fas ligand (TNF superfamily, member 6)
    Gene Ontology: [View List]
    Invivo
    hit Wenzel J (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CD48
  • BCM1
  • BLAST
  • BLAST1
  • EG962
    		•  The BioGRID Database Seperator CD48 antigen (B-cell membrane protein)|OTTHUMP00000060268; CD48 molecule
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Hawash IY (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AXL
  • UFO
  • EG558
    		•  The BioGRID Database Seperator AXL transforming sequence/gene|oncogene AXL; AXL receptor tyrosine kinase
    Gene Ontology: [View List]
    Far Western
    bait Braunger J (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KHDRBS1
  • Sam68
  • p62
  • FLJ34027
  • EG10657
    		•  The BioGRID Database Seperator KH domain containing, RNA binding, signal transduction associated 1; GAP-associated tyrosine phosphoprotein p62 (Sam68)
    Gene Ontology: [View List]
    Invivo
    bait Fusaki N (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PECAM1
  • CD31
  • PECAM-1
  • EG5175
    		•  The BioGRID Database Seperator platelet/endothelial cell adhesion molecule (CD31 antigen); CD31/EndoCAM|PECAM-1, CD31/EndoCAM|adhesion molecule
    Gene Ontology: [View List]
    Invitro
    bait Cao MY (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYK
  • EG6850
    		•  The BioGRID Database Seperator spleen tyrosine kinase
    Gene Ontology: [View List]
    Invivo
    bait Thome M (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THY1
  • CD90
  • FLJ33325
  • EG7070
    		•  The BioGRID Database Seperator Thy-1 cell surface antigen; Thy-1 T-cell antigen
    Gene Ontology: [View List]
    Invivo
    bait Thomas PM (1992)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAF1
  • CRAF
  • Raf-1
  • c-Raf
  • EG5894
    		•  The BioGRID Database Seperator Oncogene RAF1|raf proto-oncogene serine/threonine protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1
    Gene Ontology: [View List]
    Invivo
    bait Pathan NI (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC25C
  • CDC25
  • EG995
    		•  The BioGRID Database Seperator cell division cycle 25C|cell division cycle 25C protein|dual specificity phosphatase CDC25C|m-phase inducer phosphatase 3|mitosis inducer CDC25|phosphotyrosine phosphatase; cell division cycle 25 homolog C (S. pombe)
    Gene Ontology: [View List]
    Invivo
    bait Giglione C (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT1
  • SIT
  • RP11-331F...
  • MGC125908
  • EG27240
    		•  The BioGRID Database Seperator SHP2 interacting transmembrane adaptor|SHP2-interacting transmembrane adaptor protein|suppression inducing transmembrane adaptor 1; signaling threshold regulating transmembrane adaptor 1
    Gene Ontology: [View List]