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BioGRID | Network Layout for JAK2 for Homo sapiens
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JAK2

 Homo sapiens
The BioGRID Database Seperator
Aliases: EG3717
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Janus kinase 2|OTTHUMP00000043260|tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase)
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with JAK2

JAK2 was identified with 104 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SOCS1
  • CIS1
  • CISH1
  • JAB
  • EG8651
    		•  The BioGRID Database Seperator JAK binding protein|STAT induced SH3 protein 1|Tec-interacting protein 3|cytokine-inducible SH2 protein 1; suppressor of cytokine signaling 1
    Gene Ontology: [View List]
    Invivo
    hit Ungureanu D (2002)
    hit Yasukawa H (1999)
    hit Endo TA (1997)
    Invitro
    hit Ungureanu D (2002)
    hit Yasukawa H (1999)
    hit Endo TA (1997)
    Two-hybrid
    hit Ungureanu D (2002)
    hit Yasukawa H (1999)
    hit Endo TA (1997)
    Affinity Capture-Western
    bait Dif F (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOCS3
  • CIS3
  • Cish3
  • MGC71791
  • EG9021
    		•  The BioGRID Database Seperator STAT induced STAT inhibitor 3|cytokine-induced SH2 protein 3; suppressor of cytokine signaling 3
    Gene Ontology: [View List]
    Invivo
    hit Masuhara M (1997)
    Invitro
    hit Masuhara M (1997)
    Two-hybrid
    hit Masuhara M (1997)
    hit Sasaki A (1999)
    Affinity Capture-Western
    bait/hit Sasaki A (2000)
    bait Sasaki A (1999)
    Reconstituted Complex
    hit Sasaki A (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SH2B
  • DKFZp547G...
  • SH2-B
  • SH2B1
  • EG25970
    		•  The BioGRID Database Seperator SH2 domain-containing putative adapter SH2-B|SH2-B alpha signaling protein|SH2-B gamma signaling protein|SH2-B homolog; SH2B adaptor protein 1
    Gene Ontology: [View List]
    Invivo
    bait Rui L (1997)
    Invitro
    bait Rui L (1997)
    Two-hybrid
    bait Rui L (1997)
    Affinity Capture-Western
    hit Xie S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPOR
  • MGC138358
  • EG2057
    		•  The BioGRID Database Seperator erythropoietin receptor
    Gene Ontology: [View List]
    Invivo
    hit Witthuhn BA (1993)
    Invitro
    hit Witthuhn BA (1993)
    Affinity Capture-Western
    hit Huang LJ (2001)
    Reconstituted Complex
    bait Huang LJ (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCR
  • ALL
  • BCR1
  • CML
  • EG613
    		•  The BioGRID Database Seperator breakpoint cluster region protein; breakpoint cluster region
    Gene Ontology: [View List]
    Invivo
    hit Xie S (2002)
    hit Baxter EJ (2002)
    Invitro
    hit Xie S (2002)
    hit Baxter EJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHC1
  • FLJ26504
  • SHC
  • SHCA
  • EG6464
    		•  The BioGRID Database Seperator SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1
    Gene Ontology: [View List]
    Invivo
    hit VanderKuur J (1995)
    hit Giordano V (1997)
    Invitro
    hit VanderKuur J (1995)
    hit Giordano V (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTPN11
  • BPTP3
  • CFC
  • MGC14433
  • EG5781
    		•  The BioGRID Database Seperator protein tyrosine phosphatase, non-receptor type 11|protein-tyrosine phosphatase 2C; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
    Gene Ontology: [View List]
    Invivo
    hit Maegawa H (1996)
    Reconstituted Complex
    bait Yin T (1997)
    Biochemical Activity
    hit Yin T (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT5A
  • MGF
  • STAT5
  • EG6776
    		•  The BioGRID Database Seperator signal transducer and activator of transcription 5A
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Barahmand-Pour F (1998)
    Two-hybrid
    hit Fujitani Y (1997)
    Reconstituted Complex
    hit Fujitani Y (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAV1
  • VAV
  • EG7409
    		•  The BioGRID Database Seperator oncogene vav|vav 1 oncogene|vav proto-oncogene; vav 1 guanine nucleotide exchange factor
    Gene Ontology: [View List]
    Invivo
    hit Matsuguchi T (1995)
    Affinity Capture-Western
    hit Shigematsu H (1997)
    Biochemical Activity
    hit Shigematsu H (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSF2RB
  • CD131
  • CDw131
  • IL3RB
  • EG1439
    		•  The BioGRID Database Seperator Colony-stimulating factor-2 receptor, beta, low-affinity|interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity); colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
    Gene Ontology: [View List]
    Invivo
    hit Wu DW (2000)
    Reconstituted Complex
    hit Zhao Y (1995)
    Affinity Capture-Western
    bait Zhao Y (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GHR
  • GHBP
  • EG2690
    		•  The BioGRID Database Seperator growth hormone binding protein|serum binding protein|somatotropin receptor; growth hormone receptor
    Gene Ontology: [View List]
    Invivo
    hit Hellgren G (1999)
    hit VanderKuur JA (1994)
    Affinity Capture-Western
    bait Frank SJ (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IL5RA
  • CDw125
  • HSIL5R3
  • IL5R
  • EG3568
    		•  The BioGRID Database Seperator CD125 antigen|interleukin 5 receptor type 3|interleukin-5 receptor alpha chain|interleukin-5 receptor alpha subunit; interleukin 5 receptor, alpha
    Gene Ontology: [View List]
    Invitro
    hit Ogata N (1998)
    Invivo
    hit Ogata N (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRB10
  • GRB-IR
  • IRBP
  • KIAA0207
  • EG2887
    		•  The BioGRID Database Seperator GRB10 adaptor protein|maternally expressed gene 1; growth factor receptor-bound protein 10
    Gene Ontology: [View List]
    Invivo
    hit Moutoussamy S (1998)
    Invitro
    hit Moutoussamy S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FYN
  • MGC45350
  • SLK
  • SYN
  • RP1-66H14.1
    		•  The BioGRID Database Seperator OKT3-induced calcium influx regulator|c-syn protooncogene|protein-tyrosine kinase fyn|proto-oncogene tyrosine-protein kinase fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T); FYN oncogene related to SRC, FGR, YES
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Sayeski PP (1999)
    Reconstituted Complex
    bait Sayeski PP (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF1A
  • CD120a
  • FPF
  • MGC19588
  • EG7132
    		•  The BioGRID Database Seperator tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor; tumor necrosis factor receptor superfamily, member 1A
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Guo D (1998)
    Affinity Capture-Western
    bait Guo D (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAT5B
  • STAT5
  • EG6777
    		•  The BioGRID Database Seperator signal transducer and activator of transcription 5B; transcription factor STAT5B
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Barahmand-Pour F (1998)
    Two-hybrid
    hit Fujitani Y (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IL12RB2
  • RP11-102M...
  • EG3595
    		•  The BioGRID Database Seperator IL-12 receptor beta 2|interleukin 12 receptor, beta 2 (IL12RB2)|interleukin-12 receptor beta-2 chain; interleukin 12 receptor, beta 2
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Yamamoto K (1999)
    Affinity Capture-Western
    hit Yamamoto K (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEC
  • PSCTK4
  • MGC126760
  • MGC126762
  • EG7006
    		•  The BioGRID Database Seperator tec protein tyrosine kinase
    Gene Ontology: [View List]
    Invivo
    hit Yamashita Y (1998)
    Affinity Capture-Western
    hit Takahashi-Tezuka M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIT
  • C-Kit
  • CD117
  • PBT
  • EG3815
    		•  The BioGRID Database Seperator mast/stem cell growth factor receptor|proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    Gene Ontology: [View List]
    Invivo
    hit Brizzi MF (1994)
    Invitro
    hit Brizzi MF (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKB1
  • IBP72
  • JBP1
  • PRMT5
  • EG10419
    		•  The BioGRID Database Seperator HMT1 hnRNP methyltransferase-like 5|SKB1 (S. cerevisiae) homolog|SKB1 homolog|skb1 (S. pombe) homolog; protein arginine methyltransferase 5
    Gene Ontology: [View List]
    Two-hybrid
    hit Pollack BP (1999)
    Reconstituted Complex
    bait Pollack BP (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • FADK
  • FAK
  • FAK1
  • EG5747
    		•  The BioGRID Database Seperator PTK2 protein tyrosine kinase 2; focal adhesion kinase 1
    Gene Ontology: [View List]
    Invivo
    hit Ryu H (2000)
    Affinity Capture-Western
    bait Zhu T (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VCP
  • IBMPFD
  • TERA
  • p97
  • EG7415
    		•  The BioGRID Database Seperator transitional endoplasmic reticulum ATPase|yeast Cdc48p homolog; valosin-containing protein
    Gene Ontology: [View List]
    Invivo
    hit Lavoie C (2000)
    Invitro
    hit Lavoie C (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EGFR
  • ERBB
  • ERBB1
  • mENA
  • EG1956
    		•  The BioGRID Database Seperator avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Olayioye MA (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRB2
  • ASH
  • EGFRBP-GRB2
  • Grb3-3
  • EG2885
    		•  The BioGRID Database Seperator HT027|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3; growth factor receptor-bound protein 2
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Chauhan D (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRCA1
  • BRCAI
  • IRIS
  • PSCP
  • EG672
    		•  The BioGRID Database Seperator BRCA1/BRCA2-containing complex, subunit 1|breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gao B (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSPA8
  • HSC54
  • HSC70
  • HSC71
  • EG3312
    		•  The BioGRID Database Seperator LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|heat shock 70kD protein 8|heat shock 70kd protein 10|heat shock cognate protein 54|heat shock cognate protein, 71-kDa|lipopolysaccharide-associated protein 1|uncharacterized bone marrow protein...
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Sarkar S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTPN12
  • PTP-PEST
  • PTPG1
  • tcag7.1075
    		•  The BioGRID Database Seperator protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Horsch K (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTPNS1
  • BIT
  • MFR
  • MYD-1
  • EG140885
    		•  The BioGRID Database Seperator SHP substrate-1|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|macrophage fusion receptor|myd-1 antigen|protein tyrosine phosphatase, non-receptor type substrate 1|signal regulatory protein, alpha type 1|signal regulatory protein, alpha type 2|tyrosine phosphatase...
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Stofega MR (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRS1
  • HIRS-1
  • EG3667
    		•  The BioGRID Database Seperator insulin receptor substrate 1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Gual P (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2B
  • CADTK
  • CAKB
  • FADK2
  • EG2185
    		•  The BioGRID Database Seperator CAK beta|calcium-dependent tyrosine kinase|cell adhesion kinase beta|focal adhesion kinase 2|proline-rich tyrosine kinase 2|protein kinase B|protein tyrosine kinase 2 beta|related adhesion focal tyrosine kinase; PTK2B protein tyrosine kinase 2 beta
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Frank GD (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPP2R4
  • MGC2184
  • PP2A
  • PR53
  • RP11-247A...
    		•  The BioGRID Database Seperator PP2A phosphatase activator|PP2A, subunit B'|phosphotyrosyl phosphatase activator|protein phosphatase 2A, regulatory subunit B'|protein phosphatase 2A, regulatory subunit B' (PR 53); protein phosphatase 2A activator, regulatory subunit 4
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Fuhrer DK (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LYN
  • JTK8
  • FLJ26625
  • EG4067
    		•  The BioGRID Database Seperator Yamaguchi sarcoma viral (v-yes-1) oncogene homolog|Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Chin H (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTR2A
  • 5-HT2A
  • HTR2
  • RP11-147L...
    		•  The BioGRID Database Seperator 5-hydroxytryptamine (serotonin) receptor 2A; 5-HT2 receptor
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Guillet-Deniau I (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERBB2
  • HER-2
  • HER-2/neu
  • HER2
  • EG2064
    		•  The BioGRID Database Seperator c-erb B2/neu protein|erbB-2|herstatin|neuroblastoma/glioblastoma derived oncogene homolog|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene...
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ren Z (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTPN6
  • HCP
  • HCPH
  • HPTP1C
  • EG5777
    		•  The BioGRID Database Seperator 70 kda SHP-1L protein|hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C; protein tyrosine phosphatase, non-receptor type 6
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Jiao H (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IFNGR2
  • AF-1
  • IFGR2
  • IFNGT1
  • EG3460
    		•  The BioGRID Database Seperator interferon gamma receptor accessory factor-1|interferon-gamma receptor beta chain; interferon gamma receptor 2 (interferon gamma transducer 1)
    Gene Ontology: [View List]
    Invivo
    hit Igarashi K (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YES1
  • HsT441
  • P61-YES
  • Yes
  • EG7525
    		•  The BioGRID Database Seperator Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene tyrosine-protein kinase YES|viral oncogene yes-1 homolog 1; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Fuhrer DK (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIK3R1
  • GRB1
  • p85-ALPHA
  • EG5295
    		•  The BioGRID Database Seperator phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)|phosphatidylinositol 3-kinase, regulatory, 1|phosphatidylinositol 3-kinase-associated p-85 alpha|phosphoinositide-3-kinase, regulatory subunit, polypeptide 1|phosphoinositide-3-kinase, regulatory subunit, polypeptide...
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Fuhrer DK (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNAJA3
  • TID1
  • hTid-1
  • FLJ45758
  • EG9093
    		•  The BioGRID Database Seperator tumorous imaginal discs (Drosophila) homolog; DnaJ (Hsp40) homolog, subfamily A, member 3
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Sarkar S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APS
  • SH2B2
  • EG10603
    		•  The BioGRID Database Seperator adaptor protein with pleckstrin homology and src homology 2 domains; SH2B adaptor protein 2
    Gene Ontology: [View List]
    Biochemical Activity
    hit Wakioka T (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR2
  • CC-CKR-2
  • CCR2A
  • CCR2B
  • EG1231
    		•  The BioGRID Database Seperator MCP-1 receptor|chemokine (C-C) receptor 2|monocyte chemoattractant protein 1 receptor|monocyte chemotactic protein 1 receptor; chemokine (C-C motif) receptor 2
    Gene Ontology: [View List]
    Invivo
    bait Mellado M (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STAM
  • STAM1
  • DKFZp686J...
  • EG8027
    		•  The BioGRID Database Seperator signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; signal transducing adaptor molecule 1
    Gene Ontology: [View List]
    Invivo
    hit Takeshita T (1997)