Homo sapiens
HES1
HES-1, HHL, HRY, bHLHb39
hes family bHLH transcription factor 1
GO Process (32)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
- Notch signaling pathway [IDA, IMP, TAS]
- STAT protein import into nucleus [ISS]
- artery morphogenesis [ISS]
- ascending aorta morphogenesis [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- embryonic heart tube morphogenesis [ISS]
- endocrine pancreas development [TAS]
- forebrain radial glial cell differentiation [ISS]
- negative regulation of forebrain neuron differentiation [ISS]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of pro-B cell differentiation [IMP]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neuronal stem cell maintenance [IEP]
- outflow tract morphogenesis [ISS]
- pharyngeal arch artery morphogenesis [ISS]
- positive regulation of DNA binding [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of mitotic cell cycle, embryonic [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein complex assembly [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- thymus development [ISS]
- vascular smooth muscle cell development [ISS]
- ventricular septum development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [ISS]
Download Curated Data for this Protein
109514
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- Interactors 53
- Interactions 103
- Network
- PTM Sites 5