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BioGRID | Network Layout for CASP8 for Homo sapiens
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CASP8

 Homo sapiens
The BioGRID Database Seperator
Aliases: FLICE, MACH, MCH5, MGC78473, CAP4, ALPS2B, EG841
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: FADD-homologous ICE/CED-3-like protease|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|Mch5 isoform alpha|caspase 8|caspase 8, apoptosis-related cysteine protease|cysteine protease|procaspase-8; caspase 8, apoptosis-related cysteine peptidase
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CASP8

CASP8 was identified with 78 protein interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 CFLAR
  • CASH
  • CASP8AP1
  • CLARP
  • EG8837
    		•  The BioGRID Database Seperator FADD-like anti-apoptotic molecule; Inhibitor of FLICE; Caspase-related inducer of apoptosis; Caspase homolog; Caspase-like apoptosis regulatory protein|usurpin beta; CASP8 and FADD-like apoptosis regulator
    Gene Ontology: [View List]
    Invivo
    hit Micheau O (2002)
    Affinity Capture-Western
    hit Micheau O (2003)
    bait Shu HB (1997)
    hit Srinivasula SM (1997)
    Two-hybrid
    bait Goltsev YV (1997)
    bait/hit Srinivasula SM (1997)
    Reconstituted Complex
    bait Srinivasula SM (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FADD
  • GIG3
  • MGC8528
  • MORT1
  • EG8772
    		•  The BioGRID Database Seperator Fas-associated via death domain|Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor-induced toxicity; Fas (TNFRSF6)-associated via death domain
    Gene Ontology: [View List]
    Two-hybrid
    hit Thomas LR (2002)
    Co-purification
    hit Gajate C (2005)
    Affinity Capture-Western
    hit Micheau O (2003)
    hit Srinivasula SM (1997)
    bait Henshall DC (2003)
    Reconstituted Complex
    bait Srinivasula SM (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEDD2
  • FLAME-3
  • EG162989
    		•  The BioGRID Database Seperator death effector domain-containing DNA binding protein 2|death effector domain-containing DNA binding protein 2; death effector domain containing 2
    Gene Ontology: [View List]
    Invitro
    bait/hit Alcivar A (2003)
    bait/hit Zhan Y (2002)
    Invivo
    hit Zhan Y (2002)
    hit Alcivar A (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEA15
  • HMAT1
  • HUMMAT1H
  • MAT1
  • RP11-536C...
    		•  The BioGRID Database Seperator Phosphoprotein enriched in astrocytes, 15kD|homolog of mouse MAT-1 oncogene; phosphoprotein enriched in astrocytes 15
    Gene Ontology: [View List]
    Invivo
    hit Kitsberg D (1999)
    hit Condorelli G (1999)
    Invitro
    hit Kitsberg D (1999)
    hit Condorelli G (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCAP31
  • 6C6-AG
  • BAP31
  • CDM
  • EG10134
    		•  The BioGRID Database Seperator B-cell receptor-associated protein 31; accessory protein BAP31
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Ng FW (1997)
    Affinity Capture-Western
    bait Ng FW (1997)
    Biochemical Activity
    hit Ng FW (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAS
  • ALPS1A
  • APO-1
  • APT1
  • EG355
    		•  The BioGRID Database Seperator APO-1 cell surface antigen|CD95 antigen|Fas antigen|OTTHUMP00000059646|apoptosis antigen 1|tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6)
    Gene Ontology: [View List]
    Co-purification
    bait Gajate C (2005)
    Affinity Capture-Western
    bait Shu HB (1997)
    bait MacFarlane M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CASP8
  • FLICE
  • MACH
  • MCH5
  • EG841
    		•  The BioGRID Database Seperator FADD-homologous ICE/CED-3-like protease|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|Mch5 isoform alpha|caspase 8|caspase 8, apoptosis-related cysteine protease|cysteine protease|procaspase-8; caspase 8, apoptosis-related cysteine peptidase
    Gene Ontology: [View List]
    Invitro
    hit Blanchard H (2000)
    Two-hybrid
    bait/hit Stelzl U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRAF1
  • EBI6
  • MGC:10353
  • EG7185
    		•  The BioGRID Database Seperator Epstein-Bar virus-induced protein 6; TNF receptor-associated factor 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Micheau O (2003)
    Biochemical Activity
    hit Leo E (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOL3
  • ARC
  • MYC
  • NOP
  • EG8996
    		•  The BioGRID Database Seperator nucleolar protein 3 (apoptosis repressor with CARD domain); nucleolar protein 3
    Gene Ontology: [View List]
    Invivo
    hit Koseki T (1998)
    Invitro
    hit Koseki T (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CASP8AP2
  • CED-4
  • FLASH
  • FLJ11208
  • EG9994
    		•  The BioGRID Database Seperator FLASH homolog RIP25|FLICE associated huge|human FLASH; CASP8 associated protein 2
    Gene Ontology: [View List]
    Invivo
    hit Choi YH (2001)
    bait/hit Imai Y (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF10B
  • DR5
  • KILLER
  • KILLER/DR5
  • EG8795
    		•  The BioGRID Database Seperator Fas-like protein|TNF-related apoptosis-inducing ligand receptor 2|TRAIL receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA damage-inducible cell...
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)
    Affinity Capture-Western
    bait MacFarlane M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CASP10
  • ALPS2
  • FLICE2
  • MCH4
  • EG843
    		•  The BioGRID Database Seperator FADD-like ICE2|Fas-associated death domain protein|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10|caspase 10, apoptosis-related cysteine protease|interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine peptidase
    Gene Ontology: [View List]
    Co-purification
    bait Gajate C (2005)
    Affinity Capture-Western
    bait/hit Micheau O (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FASLG
  • APT1LG1
  • CD178
  • CD95L
  • EG356
    		•  The BioGRID Database Seperator CD95 ligand|apoptosis (APO-1) antigen ligand 1|fas ligand|tumor necrosis factor (ligand) superfamily, member 6; Fas ligand (TNF superfamily, member 6)
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)
    Affinity Capture-Western
    bait Micheau O (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDH3
  • CDHP
  • HJMD
  • PCAD
  • EG1001
    		•  The BioGRID Database Seperator P-cadherin|cadherin 3, P-cadherin (placental)|cadherin 3, type 1|calcium-dependent adhesion protein, placental|placental cadherin; cadherin 3, type 1, P-cadherin (placental)
    Gene Ontology: [View List]
    Invivo
    hit Schmeiser K (1999)
    Invitro
    hit Schmeiser K (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CASP6
  • MCH2
  • EG839
    		•  The BioGRID Database Seperator apoptotic protease MCH-2|caspase 6|caspase 6, apoptosis-related cysteine protease; caspase 6, apoptosis-related cysteine peptidase
    Gene Ontology: [View List]
    Invivo
    hit Cowling V (2002)
    Invitro
    hit Cowling V (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN
  • EG4478
    		•  The BioGRID Database Seperator moesin
    Gene Ontology: [View List]
    Co-purification
    bait Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RALBP1
  • RIP
  • RIP1
  • RLIP76
  • EG10928
    		•  The BioGRID Database Seperator ralA binding protein 1; ralA-binding protein
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Micheau O (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF1A
  • CD120a
  • FPF
  • MGC19588
  • EG7132
    		•  The BioGRID Database Seperator tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor; tumor necrosis factor receptor superfamily, member 1A
    Gene Ontology: [View List]
    Co-purification
    hit Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHOA
  • ARH12
  • ARHA
  • RHO12
  • EG387
    		•  The BioGRID Database Seperator Aplysia ras-related homolog 12|oncogene RHO H12|small GTP binding protein RhoA; ras homolog gene family, member A
    Gene Ontology: [View List]
    Co-purification
    bait Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARHGDIA
  • GDIA1
  • RHOGDI
  • MGC117248
  • EG396
    		•  The BioGRID Database Seperator Rho GDP dissociation inhibitor (GDI) alpha
    Gene Ontology: [View List]
    Co-purification
    bait Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIRC2
  • API1
  • HIAP2
  • Hiap-2
  • EG329
    		•  The BioGRID Database Seperator NFR2-TRAF signalling complex protein|apoptosis inhibitor 1|baculoviral IAP repeat-containing protein 2; baculoviral IAP repeat-containing 2
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Micheau O (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TNFRSF10A
  • APO2
  • DR4
  • MGC9365
  • EG8797
    		•  The BioGRID Database Seperator TNF-related apoptosis inducing ligand receptor 1|cytotoxic TRAIL receptor|death receptor 4; tumor necrosis factor receptor superfamily, member 10a
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait MacFarlane M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APAF1
  • CED4
  • DKFZp781B...
  • EG317
    		•  The BioGRID Database Seperator apoptotic peptidase activating factor 1; apoptotic protease activating factor 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Hu Y (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NR1H4
  • BAR
  • FXR
  • HRR-1
  • EG9971
    		•  The BioGRID Database Seperator nuclear receptor subfamily 1, group H, member 4; farnesoid X receptor
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Stegh AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VIM
  • FLJ36605
  • RP11-124N...
    		•  The BioGRID Database Seperator vimentin
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Stelzl U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFCP2
  • CP2
  • LBP-1C
  • LSF
  • EG7024
    		•  The BioGRID Database Seperator SAA3 enhancer factor|Transcription factor CP2, alpha globin; transcription factor CP2
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Stelzl U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRAF2
  • MGC:45012
  • TRAP
  • TRAP3
  • EG7186
    		•  The BioGRID Database Seperator OTTHUMP00000064745|tumor necrosis factor type 2 receptor associated protein 3; TNF receptor-associated factor 2
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Micheau O (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAPK8
  • JNK
  • JNK1
  • JNK1A2
  • EG5599
    		•  The BioGRID Database Seperator JNK1 alpha protein kinase|JNK1 beta protein kinase|c-Jun N-terminal kinase 1|protein kinase JNK1|stress-activated protein kinase JNK1; mitogen-activated protein kinase 8
    Gene Ontology: [View List]
    Co-purification
    bait Gajate C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHD3
  • Mi-2a
  • Mi2-ALPHA
  • ZFH
  • EG1107
    		•  The BioGRID Database Seperator chromodomain helicase DNA binding protein 3; zinc-finger helicase (Snf2-like)
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Stelzl U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRADD
  • Hs.89862
  • MGC11078
  • EG8717
    		•  The BioGRID Database Seperator TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor-1-associated protein; TNFRSF1A-associated via death domain
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Micheau O (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIP1
  • MGC126506
  • ILWEQ
  • EG3092
    		•  The BioGRID Database Seperator huntingtin interacting protein 1
    Gene Ontology: [View List]
    Invivo
    hit Gervais FG (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP3K14
  • FTDCR1B
  • HS
  • HSNIK
  • EG9020
    		•  The BioGRID Database Seperator mitogen-activated protein kinase kinase kinase 14; serine/threonine protein-kinase
    Gene Ontology: [View List]
    Invivo
    hit Chaudhary PM (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CASP14
  • MGC119078
  • MGC119079
  • EG23581
    		•  The BioGRID Database Seperator apoptosis-related cysteine protease|caspase 14|caspase 14, apoptosis-related cysteine protease; caspase 14, apoptosis-related cysteine peptidase
    Gene Ontology: [View List]
    Invivo
    hit Hu S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CARD4
  • NOD1
  • CLR7.1
  • NLRC1
  • EG10392
    		•  The BioGRID Database Seperator NLR family, CARD domain containing 1|caspase recruitment domain 4|caspase recruitment domain family, member 4|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; nucleotide-binding oligomerization domain containing 1
    Gene Ontology: [View List]
    Invivo
    bait/hit Inohara N (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHUK
  • IKBKA
  • IKK-alpha
  • IKK1
  • EG1147
    		•  The BioGRID Database Seperator I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|conserved helix-loop ubiquitous kinase; conserved helix-loop-helix ubiquitous kinase
    Gene Ontology: [View List]
    Invivo
    hit Chaudhary PM (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDH1
  • Arc-1
  • CDHE
  • ECAD
  • EG999
    		•  The BioGRID Database Seperator cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin; cadherin 1, type 1, E-cadherin (epithelial)
    Gene Ontology: [View List]
    Invivo
    hit Jamal S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTNNB1
  • CTNNB
  • FLJ25606
  • DKFZp686D...
  • EG1499
    		•  The BioGRID Database Seperator catenin (cadherin-associated protein), beta 1 (88kD)|catenin (cadherin-associated protein), beta 1 (88kDa; catenin (cadherin-associated protein), beta 1, 88kDa
    Gene Ontology: [View List]
    Invivo
    hit Jamal S (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCL2
  • Bcl-2
  • EG596
    		•  The BioGRID Database Seperator B-cell lymphoma protein 2; B-cell CLL/lymphoma 2
    Gene Ontology: [View List]
    Invivo
    hit Poulaki V (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESRRBL1
  • FLJ10147
  • HIPPI
  • MHS4R2
  • EG55081
    		•  The BioGRID Database Seperator HIP1 protein interactor|estrogen-related receptor beta like 1|huntingtin interacting protein-1 interacting protein; intraflagellar transport 57 homolog (Chlamydomonas)
    Gene Ontology: [View List]
    Invivo
    hit Gervais FG (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAP4K4
  • FLH21957
  • FLJ20373
  • HGK
  • EG9448
    		•  The BioGRID Database Seperator HPK/GCK-like kinase|hepatocyte progenitor kinase-like/germinal center kinase-like kinase; mitogen-activated protein kinase kinase kinase kinase 4
    Gene Ontology: [View List]
    Invivo
    hit Chaudhary PM (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APP
  • AAA
  • ABETA
  • ABPP
  • EG351
    		•  The BioGRID Database Seperator A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|protease nexin-II; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
    Gene Ontology: [View List]
    Invitro
    bait Gunyuzlu PL (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEDD
  • CASP8IP1
  • DEDD1