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BioGRID | Network Layout for APP for Homo sapiens
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APP

 Homo sapiens
The BioGRID Database Seperator
Aliases: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, EG351
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|protease nexin-II; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [OMIM]  [HGNC]  [HPRD]  [Ensembl]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 12 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with APP

APP was identified with 99 protein interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SHC1
  • FLJ26504
  • SHC
  • SHCA
  • EG6464
    		•  The BioGRID Database Seperator SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1
    Gene Ontology: [View List]
    Invivo
    hit Tarr PE (2002)
    hit Zambrano N (1997)
    Invitro
    hit Tarr PE (2002)
    hit Zambrano N (1997)
    Two-hybrid
    hit Tarr PE (2002)
    hit Zambrano N (1997)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APBB1
  • FE65
  • MGC:9072
  • RIR
  • EG322
    		•  The BioGRID Database Seperator adaptor protein FE65a2|amyloid beta A4 precursor protein-binding, family B, member 1|stat-like protein; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
    Gene Ontology: [View List]
    Invivo
    hit Borg JP (1996)
    hit McLoughlin DM (1996)
    hit Hu Q (1998)
    Invitro
    hit Borg JP (1996)
    hit McLoughlin DM (1996)
    hit Hu Q (1998)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HADH2
  • 17b-HSD10
  • ABAD
  • ERAB
  • RP3-339A1...
    		•  The BioGRID Database Seperator 17-beta-hydroxysteroid dehydrogenase type 10|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|AB-binding alcohol dehydrogenase|amyloid-beta binding polypeptide|amyloid-beta peptide binding alcohol dehydrogenase|endoplasmic reticulum-associated amyloid-beta peptide binding protein|hydroxyacyl-Coenzyme...
    Gene Ontology: [View List]
    Invivo
    hit Oppermann UC (1999)
    hit Yan SD (1997)
    Two-hybrid
    hit Oppermann UC (1999)
    hit Yan SD (1997)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APBB2
  • FE65L
  • FE65L1
  • MGC35575
  • EG323
    		•  The BioGRID Database Seperator amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like); Fe65-like|amyloid beta A4 precursor protein-binding, family B, member 2
    Gene Ontology: [View List]
    Invivo
    hit Guenette SY (1996)
    Invitro
    hit Guenette SY (1996)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    Affinity Capture-Western
    bait Chang Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BLMH
  • BH
  • BMH
  • EG642
    		•  The BioGRID Database Seperator bleomycin hydrolase
    Gene Ontology: [View List]
    Invitro
    hit Lefterov IM (2000)
    Two-hybrid
    hit Lefterov IM (2000)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APPBP1
  • A-116A10.1
  • HPP1
  • NAE1
  • EG8883
    		•  The BioGRID Database Seperator NEDD8-activating enzyme E1 subunit|amyloid beta precursor protein binding protein 1, 59kDa|amyloid beta precursor protein-binding protein 1, 59kD|amyloid protein-binding protein 1|protooncogene protein 1; NEDD8 activating enzyme E1 subunit 1
    Gene Ontology: [View List]
    Invivo
    hit Chow N (1996)
    Invitro
    hit Chow N (1996)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SERPINA3
  • AACT
  • ACT
  • MGC88254
  • EG12
    		•  The BioGRID Database Seperator alpha-1-antichymotrypsin|antichymotrypsin|growth-inhibiting protein 24|growth-inhibiting protein 25|serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3|serine (or cysteine) proteinase inhibitor, clade A, member 3|serpin peptidase inhibitor, clade...
    Gene Ontology: [View List]
    Invivo
    hit Janciauskiene S (1998)
    hit Abraham CR ()
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APPBP2
  • HS.84084
  • KIAA0228
  • PAT1
  • EG10513
    		•  The BioGRID Database Seperator amyloid beta precursor protein (cytoplasmic tail)-binding protein 2|amyloid beta precursor protein-binding protein 2|protein interacting with APP tail 1; amyloid beta precursor protein (cytoplasmic tail) binding protein 2
    Gene Ontology: [View List]
    Invitro
    hit Zheng P (1998)
    Two-hybrid
    hit Zheng P (1998)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMOX2
  • HO-2
  • EG3163
    		•  The BioGRID Database Seperator heme oxygenase (decyclizing) 2; heme oxygenase (decycling) 2
    Gene Ontology: [View List]
    Invivo
    hit Dore S (2002)
    Two-hybrid
    hit Dore S (2002)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APBA2
  • D15S1518E
  • HsT16821
  • LIN-10
  • EG321
    		•  The BioGRID Database Seperator X11-like protein|adapter protein X11beta|amyloid beta A4 precursor protein-binding, family A, member 2|neuron-specific X11L protein|neuronal munc18-1-interacting protein 2|phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family...
    Gene Ontology: [View List]
    Invivo
    hit Tomita S (1999)
    Invitro
    hit Tomita S (1999)
    Affinity Capture-Western
    bait/hit Araki Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUMB
  • S171
  • EG8650
    		•  The BioGRID Database Seperator numb homolog (Drosophila); numb homolog
    Gene Ontology: [View List]
    Invitro
    hit Roncarati R (2002)
    Invivo
    hit Roncarati R (2002)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APBB3
  • FE65L2
  • MGC87674
  • SRA
  • EG10307
    		•  The BioGRID Database Seperator FE65-like protein 2|amyloid beta precursor protein-binding, family B, member 3|amyloid precursor interacting protein; amyloid beta (A4) precursor protein-binding, family B, member 3
    Gene Ontology: [View List]
    Invitro
    hit Tanahashi H (1999)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KNS2
  • KLC
  • KLC1
  • KNS2A
  • EG3831
    		•  The BioGRID Database Seperator kinesin 2 (60-70kD)|kinesin 2 60/70kDa|medulloblastoma antigen MU-MB-2.50; kinesin light chain 1
    Gene Ontology: [View List]
    Invitro
    hit Kamal A (2000)
    Invivo
    hit Kamal A (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLSTN1
  • CSTN1
  • KIAA0911
  • PIK3CD
  • EG22883
    		•  The BioGRID Database Seperator alcadein alpha 1|non-classical cadherin XB31alpha1; calsyntenin 1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Araki Y (2004)
    hit Araki Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BCAP31
  • 6C6-AG
  • BAP31
  • CDM
  • EG10134
    		•  The BioGRID Database Seperator B-cell receptor-associated protein 31; accessory protein BAP31
    Gene Ontology: [View List]
    Invivo
    hit Wang B (2003)
    Two-hybrid
    hit Wang B (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRP1
  • A2MR
  • APOER
  • APR
  • EG4035
    		•  The BioGRID Database Seperator alpha-2-macroglobulin receptor|low density lipoprotein-related protein 1|type V tgf-beta receptor; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
    Gene Ontology: [View List]
    Invivo
    hit Goto JJ ()
    hit Kounnas MZ (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CALR
  • RO
  • SSA
  • cC1qR
  • EG811
    		•  The BioGRID Database Seperator Sicca syndrome antigen A (autoantigen Ro; calreticulin)|autoantigen Ro; calreticulin
    Gene Ontology: [View List]
    Invivo
    hit Johnson RJ ()
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     F12
  • HAF
  • HAE3
  • HAEX
  • EG2161
    		•  The BioGRID Database Seperator Angioneurotic edema, hereditary, with normal C1-inhibitor concentration and function|Hageman factor|coagulation factor XII; coagulation factor XII (Hageman factor)
    Gene Ontology: [View List]
    Invivo
    hit Bergamaschini L (2001)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COL4A6
  • MGC88184
  • RP5-889N1...
    		•  The BioGRID Database Seperator collagen IV, alpha-6 polypeptide|collagen of basement membrane, alpha-6|dJ889N15.4 (Collagen Alpha 6(IV))|type IV alpha 6 collagen; collagen, type IV, alpha 6
    Gene Ontology: [View List]
    Invitro
    hit Caceres J (1997)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HADHB
  • MSTP029
  • MGC87480
  • TP-BETA
  • EG3032
    		•  The BioGRID Database Seperator 2-enoyl-Coenzyme A (CoA) hydratase, beta subunit|3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunit|acetyl-CoA acyltransferase|beta-ketothiolase|hydroxyacyl-Coenzyme A (CoA) dehydrogenase, beta subunit|mitochondrial trifunctional enzyme, bet...
    Gene Ontology: [View List]
    Invitro
    hit Frackowiak J (2001)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APBA3
  • MGC:15815
  • X11L2
  • mint3
  • EG9546
    		•  The BioGRID Database Seperator X11-like 2 protein|adapter protein X11gamma|amyloid beta (A4) precursor protein-binding, family A, member 3|neuron-specific X11L2 protein|neuronal munc18-1-interacting protein 3|phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family...
    Gene Ontology: [View List]
    Invivo
    hit Tanahashi H (1999)
    Invitro
    hit Tanahashi H (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BGN
  • DSPG1
  • PG-S1
  • PGI
  • EG633
    		•  The BioGRID Database Seperator biglycan proteoglycan|bone/cartilage proteoglycan-I|dermatan sulphate proteoglycan I|small leucine-rich protein 1A; biglycan
    Gene Ontology: [View List]
    Invitro
    hit Snow AD (1995)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSN
  • DKFZp313L...
  • RP11-477J...
    		•  The BioGRID Database Seperator gelsolin (amyloidosis, Finnish type); gelsolin
    Gene Ontology: [View List]
    Invivo
    hit Chauhan VP (1999)
    Invitro
    hit Chauhan VP (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APBA1
  • D9S411E
  • MINT1
  • X11
  • EG320
    		•  The BioGRID Database Seperator adaptor protein X11alpha|amyloid beta A4 precursor protein-binding, family A, member 1|neuron-specific X11 protein|neuronal munc18-1-interacting protein 1|phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
    Gene Ontology: [View List]
    Invivo
    hit Borg JP (1996)
    Invitro
    hit Borg JP (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAV1
  • CAV
  • MSTP085
  • VIP21
  • EG857
    		•  The BioGRID Database Seperator caveolae protein, 22-kD|caveolin 1|caveolin 1 caveolae protein, 22kD|caveolin 1, alpha isoform|caveolin 1, beta isoform|cell growth-inhibiting protein 32; caveolin 1, caveolae protein, 22kDa
    Gene Ontology: [View List]
    Invitro
    hit Ikezu T (1998)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COL25A1
  • CLAC
  • EG84570
    		•  The BioGRID Database Seperator collagen-like Alzheimer amyloid plaque component|collagenous Alzheimer amyloid plaque component; collagen, type XXV, alpha 1
    Gene Ontology: [View List]
    Invivo
    hit Hashimoto T (2002)
    Invitro
    hit Hashimoto T (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSEN1
  • AD3
  • FAD
  • PS1
  • EG5663
    		•  The BioGRID Database Seperator presenilin 1 (Alzheimer disease 3); presenilin 1
    Gene Ontology: [View List]
    Invitro
    hit Ray WJ (1999)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAPDH
  • G3PD
  • GAPD
  • MGC88685
  • EG2597
    		•  The BioGRID Database Seperator aging-associated gene 9 protein|glyceraldehyde 3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase
    Gene Ontology: [View List]
    Invitro
    hit Schulze H (1993)
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNCA
  • NACP
  • PARK1
  • PARK4
  • EG6622
    		•  The BioGRID Database Seperator alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid; synuclein, alpha (non A4 component of amyloid precursor)
    Gene Ontology: [View List]
    Invitro
    hit Jensen PH (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COL4A3
  • EG1285
    		•  The BioGRID Database Seperator Goodpasture antigen|alpha 3 type IV collagen|alpha3 type IV collagen|collagen IV, alpha-3 polypeptide|tumstatin; collagen, type IV, alpha 3 (Goodpasture antigen)
    Gene Ontology: [View List]
    Invitro
    hit Caceres J (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NID
  • NID1
  • EG4811
    		•  The BioGRID Database Seperator enactin|entactin; nidogen 1
    Gene Ontology: [View List]
    Invitro
    hit Kiuchi Y (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTRB1
  • CTRB
  • MGC88037
  • FLJ42412
  • EG1504
    		•  The BioGRID Database Seperator chymotrypsinogen B1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGFB1
  • CED
  • DPD1
  • TGFB
  • EG7040
    		•  The BioGRID Database Seperator TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor beta 1|transforming growth factor, beta 1 (Camurati-Engelmann disease)|transforming growth factor-beta 1; transforming growth factor, beta 1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APP
  • AAA
  • ABETA
  • ABPP
  • EG351
    		•  The BioGRID Database Seperator A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|protease nexin-II; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Rual JF (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRSS3
  • MTG
  • PRSS4
  • TRY3
  • RP11-176F...
    		•  The BioGRID Database Seperator OTTHUMP00000045395|brain trypsinogen|mesotrypsin|mesotrypsinogen|pancreatic trypsinogen III|protease serine 4|protease, serine, 4 (trypsin 4, brain)|trypsin 3|trypsin 4, brain|trypsinogen 4|trypsinogen 5; protease, serine, 3 (mesotrypsin)
    Gene Ontology: [View List]
    Invitro
    hit Katona G (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COL4A5
  • ASLN
  • ATS
  • CA54
  • RP6-24A23.5
    		•  The BioGRID Database Seperator alpha 5 type IV collagen|collagen IV, alpha-5 polypeptide|collagen of basement membrane, alpha-5 chain|dA149D17.3 (Collagen, type IV, alpha 5)|dA24A23.1 (collagen, type IV, alpha 5 (Alport syndrome)); collagen, type IV, alpha 5 (Alport syndrome)
    Gene Ontology: [View List]
    Invitro
    hit Caceres J (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COL4A1
  • arresten
  • EG1282
    		•  The BioGRID Database Seperator COL4A1 NC1 domain|alpha 1 type IV collagen|collagen IV, alpha-1 polypeptide|collagen of basement membrane, alpha-1 chain; collagen, type IV, alpha 1
    Gene Ontology: [View List]
    Invitro
    hit Caceres J (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COL1A2
  • OI4
  • EG1278
    		•  The BioGRID Database Seperator Collagen I, alpha-2 polypeptide|Collagen of skin, tendon and bone, alpha-2 chain|alpha 2 type I collagen|alpha 2(I)-collagen|alpha-2 collagen type I|osteogenesis imperfecta type IV|type I procollagen; collagen, type I, alpha 2
    Gene Ontology: [View List]
    Invitro
    hit Potempska A (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAB1
  • RP6-239D1...
    		•  The BioGRID Database Seperator disabled homolog 1 (Drosophila); disabled homolog 1
    Gene Ontology: [View List]
    Invitro
    hit Homayouni R (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KNG1
  • BDK
  • KNG
  • EG3827
    		•  The BioGRID Database Seperator alpha-2-thiol proteinase inhibitor|bradykinin; kininogen 1
    Gene Ontology: [View List]
    Invivo
    hit Das A (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACHE
  • YT
  • ARACHE
  • N-ACHE
  • EG43
    		•  The BioGRID Database Seperator acetylcholinesterase|apoptosis-related acetylcholinesterase; acetylcholinesterase (YT blood group)
    Gene Ontology: [View List]
    Invitro