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APOE
Homo sapiens
Aliases:
AD2, MGC1571, apoprotein, EG348
Description:
apolipoprotein E3; apolipoprotein E
Links:
[Entrez-Gene]
[OMIM]
[HGNC]
[HPRD]
[Ensembl]
Gene Ontology:
21 total GO annotations for this record.
[view list]
Function
Process
Component
•
antioxidant activity
(
NAS
)
•
beta-amyloid binding
(
IDA
)
•
heparin binding
(
NAS
)
•
tau protein binding
(
TAS
)
•
apolipoprotein E receptor ...
(
NAS
)
•
phospholipid binding
(
TAS
)
•
induction of apoptosis
(
IDA
)
•
lipid transport
(
TAS
)
•
cytoskeleton organization ...
(
TAS
)
•
blood circulation
(
NAS
)
•
regulation of axon extens ...
(
TAS
)
•
response to reactive oxyg ...
(
NAS
)
•
lipoprotein metabolic pro ...
(
NAS
)
•
synaptic transmission, ch ...
(
TAS
)
•
cholesterol homeostasis
(
TAS
)
•
learning and/or memory
(
TAS
)
•
regulation of neuronal sy ...
(
TAS
)
•
intracellular transport
(
TAS
)
•
protein tetramerization
(
IDA
)
•
cytoplasm
(
TAS
)
•
extracellular region
(
TAS
)
Download interactions associated with APOE
APOE was identified with
7
protein interactions
Name
Aliases
Description
Evidence Code
Role
Source [Interactions]
A2M
DKFZp779B...
FWP007
S863-7
EG2
alpha-2-macroglobulin
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Krimbou L (1998)
[
2
]
Reconstituted Complex
bait
Krimbou L (1998)
[
2
]
MAPT
DDPAC
FLJ31424
FTDP-17
EG4137
G protein beta1/gamma2 subunit-interacting factor 1|microtubule-associated protein tau, isoform 4; microtubule-associated protein tau
Gene Ontology:
[View List]
Reconstituted Complex
bait
Fleming LM (1996)
[
2
]
NEF3
NEFM
NF-M
NFM
EG4741
neurofilament, medium polypeptide 150kDa; neurofilament-3 (150 kD medium)
Gene Ontology:
[View List]
Reconstituted Complex
hit
Fleming LM (1996)
[
2
]
LRP2
gp330
DBS
EG4036
Heymann nephritis antigen homolog|calcium sensor protein|megalin; low density lipoprotein-related protein 2
Gene Ontology:
[View List]
Reconstituted Complex
hit
Kounnas MZ (1995)
[
2
]
PLTP
HDLCQ9
EG5360
phospholipid transfer protein; lipid transfer protein II
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Siggins S (2003)
[
1
]
LRP8
APOER2
HSZ75190
MCI1
EG7804
apolipoprotein E receptor 2|low density lipoprotein receptor-related protein 8; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene Ontology:
[View List]
Reconstituted Complex
hit
Li X (2003)
[
1
]
Copyright © 2009,
Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.