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[JPG]
[PNG]
[SVG]
APOE
Homo sapiens
Aliases:
LDLCQ5, LPG, MGC1571, AD2
Description:
apolipoprotein E3
Links:
[UniprotKB]
|
[HPRD]
|
[OMIM]
|
[Entrez Gene]
Gene Ontology:
58 total GO annotations for this record.
[view list]
Function
Process
Component
•
protein heterodimerizatio ...
(
IPI
)
•
lipid transporter activit ...
(
IDA
)
•
very-low-density lipoprot ...
(
IDA
)
•
low-density lipoprotein r ...
(
IDA
)
•
antioxidant activity
(
IDA
)
•
phospholipid binding
(
IDA
)
•
phosphatidylcholine-stero ...
(
IDA
)
•
metal chelating activity
(
IDA
)
•
low-density lipoprotein r ...
(
IPI
)
•
protein homodimerization ...
(
IDA
)
•
beta-amyloid binding
(
IDA
)
•
tau protein binding
(
IPI
)
•
very-low-density lipoprot ...
(
IPI
)
•
cytoskeleton organization
(
TAS
)
•
negative regulation of pl ...
(
IDA
)
•
very-low-density lipoprot ...
(
IGI
)
•
high-density lipoprotein ...
(
IDA
)
•
high-density lipoprotein ...
(
IDA
)
•
very-low-density lipoprot ...
(
IDA
)
•
triglyceride metabolic pr ...
(
IMP
)
•
positive regulation of ch ...
(
IGI
)
•
very-low-density lipoprot ...
(
IDA
)
•
very-low-density lipoprot ...
(
IMP
)
•
positive regulation of cG ...
(
IDA
)
•
positive regulation of ch ...
(
IDA
)
•
Cdc42 protein signal tran ...
(
IDA
)
•
synaptic transmission, ch ...
(
TAS
)
•
anti-apoptosis
(
IDA
)
•
phospholipid efflux
(
IDA
)
•
negative regulation of in ...
(
IC
)
•
G-protein coupled recepto ...
(
IDA
)
•
nitric oxide mediated sig ...
(
IDA
)
•
high-density lipoprotein ...
(
IGI
)
•
chylomicron remnant clear ...
(
IMP
)
•
intracellular transport
(
TAS
)
•
triglyceride metabolic pr ...
(
IDA
)
•
regulation of neuronal sy ...
(
TAS
)
•
negative regulation of en ...
(
IDA
)
•
receptor-mediated endocyt ...
(
IDA
)
•
positive regulation of me ...
(
IDA
)
•
positive regulation of ni ...
(
IDA
)
•
positive regulation of ch ...
(
IDA
)
•
response to reactive oxyg ...
(
NAS
)
•
negative regulation of bl ...
(
IDA
)
•
induction of apoptosis
(
IDA
)
•
reverse cholesterol trans ...
(
IDA
)
•
negative regulation of ch ...
(
IDA
)
•
regulation of axon extens ...
(
TAS
)
•
negative regulation of MA ...
(
IDA
)
•
positive regulation of lo ...
(
IDA
)
•
cGMP-mediated signaling
(
IDA
)
•
low-density lipoprotein p ...
(
IDA
)
•
intermediate-density lipo ...
(
IDA
)
•
cell soma
(
NAS
)
•
extracellular region
(
EXP
)
•
plasma membrane
(
EXP
)
•
cytoplasm
(
TAS
)
•
dendrite
(
NAS
)
Download interactions associated with APOE
APOE was identified with
7
protein interactions
Name
Aliases
Description
Evidence Code
Role
Source [Interactions]
A2M
FWP007
S863-7
DKFZp779B...
alpha-2-macroglobulin
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Krimbou L (1998)
[
2
]
Reconstituted Complex
bait
Krimbou L (1998)
[
2
]
MAPT
MAPTL
DDPAC
MGC138549
G protein beta1/gamma2 subunit-interacting factor 1
Gene Ontology:
[View List]
Reconstituted Complex
bait
Fleming LM (1996)
[
2
]
NEFM
NFM
NEF3
NF-M
neurofilament, medium polypeptide 150kDa
Gene Ontology:
[View List]
Reconstituted Complex
hit
Fleming LM (1996)
[
2
]
LRP2
DBS
gp330
low density lipoprotein-related protein 2
Gene Ontology:
[View List]
Reconstituted Complex
hit
Kounnas MZ (1995)
[
2
]
PLTP
HDLCQ9
phospholipid transfer protein
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Siggins S (2003)
[
1
]
LRP8
HSZ75190
APOER2
MCI1
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene Ontology:
[View List]
Reconstituted Complex
hit
Li X (2003)
[
1
]
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Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.