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ADAM10
Homo sapiens
Aliases:
HsT18717, MADM, kuz, CD156c, EG102
Description:
a disintegrin and metalloprotease domain 10|a disintegrin and metalloproteinase domain 10|kuzbanian; ADAM metallopeptidase domain 10
Links:
[Entrez-Gene]
[OMIM]
[HGNC]
[HPRD]
[Ensembl]
Gene Ontology:
22 total GO annotations for this record.
[view list]
Function
Process
Component
•
metalloendopeptidase acti ...
(
NAS
)
•
integrin binding
(
NAS
)
•
protein kinase binding
(
ISS
)
•
protein homodimerization ...
(
ISS
)
•
protein binding
(
ISS
)
•
SH2 domain binding
(
ISS
)
•
in utero embryonic develo ...
(
ISS
)
•
cell-cell signaling
(
NAS
)
•
nucleocytoplasmic transpo ...
(
ISS
)
•
Notch signaling pathway
(
ISS
)
•
constitutive protein ecto ...
(
IDA
)
•
negative regulation of ce ...
(
NAS
)
•
integrin-mediated signali ...
(
NAS
)
•
Notch receptor processing
(
ISS
)
•
protein amino acid phosph ...
(
ISS
)
•
nucleus
(
ISS
)
•
cytoplasm
(
ISS
)
•
Golgi-associated vesicle
(
IDA
)
•
Golgi apparatus
(
IDA
)
•
integral to plasma membra ...
(
TAS
)
•
integral to membrane
(
NAS
)
•
cell surface
(
IDA
)
Download interactions associated with ADAM10
ADAM10 was identified with
4
protein interactions
Name
Aliases
Description
Evidence Code(s)
Role
Source(s)
LCK
YT16
p56lck
pp58lck
EG3932
T-lymphocyte specific protein tyrosine kinase p56lck|p56(LSTRA) protein-tyrosine kinase|protein tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK; lymphocyte-specific protein tyrosine kinase
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Poghosyan Z (2002)
GRB2
ASH
EGFRBP-GRB2
Grb3-3
EG2885
HT027|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3; growth factor receptor-bound protein 2
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Poghosyan Z (2002)
MAD2L1
HSMAD2
MAD2
EG4085
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1|MAD2-like 1|MAD2-like protein 1|mitotic arrest deficient, yeast, homolog-like 1; MAD2 mitotic arrest deficient-like 1 (yeast)
Gene Ontology:
[View List]
Affinity Capture-Western
hit
Poghosyan Z (2002)
EFNA2
ELF-1
EPLG6
HEK7-L
EG1943
HEK7-ligand|eph-related receptor tyrosine kinase ligand 6|ligand of eph-related kinase 6; ephrin-A2
Gene Ontology:
[View List]
Affinity Capture-Western
bait
Hattori M (2000)
Copyright © 2009,
Tyers Lab
, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, All Rights Reserved.
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Osprey Network Visualization System
BioGRID: A General Repository for Interaction Datasets.
Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
Nucleic Acids Res. Jan 1;34:D535-9.